Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2019 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2019 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor

  • Authors:
    • Ping Ren
    • Meiling Hu
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, The Affiliated Hospital of Ningbo University School of Medicine, Ningbo, Zhejiang 315020, P.R. China, Department of Surgery, Cixi People's Hospital of Zhejiang, Ningbo, Zhejiang 315300, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6164-6170
    |
    Published online on: October 14, 2019
       https://doi.org/10.3892/ol.2019.10990
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The prognostic significance of long non‑coding RNAs (lncRNAs) in Wilms' tumor (WT) remains unclear. The present study identified differential lncRNA expression patterns between WT and normal tissues; and evaluated the prognostic value of these lncRNAs. Multidimensional data from 136 samples were retrieved from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. Computational data analyses were performed to detect survival‑associated molecular signatures. Kaplan‑Meier survival curves revealed the prognostic prediction values for three of these lncRNAs, namely DLGAP1 antisense RNA 2 (DLGAP1‑AS2), RP11‑93B14.6 and RP11554F20.1. Cox regression analysis revealed that the three‑lncRNA signature was significantly associated with patient survival (P<0.01). Functional enrichment analyses suggested that the target genes of these three lncRNAs may be involved in known cancer‑associated pathways. The present study revealed a three‑lncRNA signature consisting of DLGAP1‑AS2, RP11‑93B14.6 and RP11554F20.1 that may be used as a prognostic marker for patients with WT.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Noone A, Howlader N, Krapcho M, Miller D, Brest A and Yu M: SEER cancer statistics review, 1975–2015, based on November 2017 SEER data submission, posted to the SEER website, April 2018.

2 

Scott RH, Stiller CA, Walker L and Rahman N: Syndromes and constitutional chromosomal abnormalities associated with Wilms tumour. J Med Genet. 43:705–715. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Dome JS, Graf N, Geller JI, Fernandez CV, Mullen EA, Spreafico F, Van den Heuvel-Eibrink M and Pritchard-Jones K: Advances in Wilms tumor treatment and biology: Progress through international collaboration. J Clin Oncol. 33:2999–3007. 2015. View Article : Google Scholar : PubMed/NCBI

4 

D'Angelo P, Di Cataldo A, Terenziani M, Bisogno G, Collini P, Di Martino M, Melchionda F, Mosa C, Nantron M, Perotti D, et al: Factors possibly affecting prognosis in children with Wilms' tumor diagnosed before 24 months of age: A report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) Wilms tumor working group. Pediatr Blood Cancer. 642017.doi: 10.1002/pbc.26644. PubMed/NCBI

5 

Bernstein L, Linet M and Smith M: Renal tumorsNational Cancer Institute, SEER Program. Bethesda, MD: National Institutes of Health; pp. 79–90. 1999

6 

Mitchell C, Pritchard-Jones K, Shannon R, Hutton C, Stevens S, Machin D, Imeson J, Kelsey A, Vujanic GM, Gornall P, et al: Immediate nephrectomy versus preoperative chemotherapy in the management of non-metastatic Wilms' tumour: Results of a randomised trial (UKW3) by the UK Children's Cancer Study Group. Eur J Cancer. 42:2554–2562. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Malogolowkin M, Spreafico F, Dome JS, van Tinteren H, Pritchard-Jones K, van den Heuvel-Eibrink MM, Bergeron C, de Kraker J and Graf N; COG Renal Tumors Committee and the SIOP Renal Tumor Study Group, : Incidence and outcomes of patients with late recurrence of Wilms' tumor. Pediatr Blood Cancer. 6:1612–1615. 2013. View Article : Google Scholar

8 

Venkatramani R, Chi YY, Coppes MJ, Malogolowkin M, Kalapurakal JA, Tian J and Dome JS: Outcome of patients with intracranial relapse enrolled on national Wilms tumor study group clinical trials. Pediatr Blood Cancer. 642017.doi: 10.1002/pbc.26406. PubMed/NCBI

9 

Clark MB, Johnston RL, Inostroza-Ponta M, Fox AH, Fortini E, Moscato P, Dinger ME and Mattick JS: Genome-wide analysis of long noncoding RNA stability. Genome Res. 22:885–898. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Tani H, Imamachi N, Mizutani R, Imamura K, Kwon Y, Miyazaki S, Maekawa S, Suzuki Y and Akimitsu N: Genome-wide analysis of long noncoding RNA turnover. Methods Mol Biol. 1262:305–320. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Carpenter S: Long noncoding RNA: Novel links between gene expression and innate immunity. Virus Res. 212:137–145. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Li CH and Chen Y: Insight into the role of long noncoding RNA in cancer development and progression. Int Rev Cell Mol Biol. 326:33–65. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Moran VA, Perera RJ and Khalil AM: Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs. Nucleic Acids Res. 40:6391–6400. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Dong X, Chen R, Lin H, Lin T and Pan S: LncRNA BG981369 inhibits cell proliferation, migration, and invasion, and promotes cell apoptosis by SRY-related high-mobility group box 4 (SOX4) signaling pathway in human gastric cancer. Med Sci Monit. 24:718–726. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Lian Y, Xiao C, Yan C, Chen D, Huang Q, Fan Y, Li Z and Xu H: Knockdown of pseudogene derived from LncRNA DUXAP10 inhibits cell proliferation, migration, invasion, and promotes apoptosis in pancreatic cancer. J Cell Biochem. 119:3671–3682. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Lin MT, Song HJ and Ding XY: Long non-coding RNAs involved in metastasis of gastric cancer. World J Gastroenterol. 24:3724–3737. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Rönnau CG, Verhaegh GW, Luna-Velez MV and Schalken JA: Noncoding RNAs as novel biomarkers in prostate cancer. Biomed Res Int. 2014:5917032014. View Article : Google Scholar : PubMed/NCBI

18 

Zhu KR, Sun QF and Zhang YQ: Long non-coding RNA LINP1 induces tumorigenesis of Wilms' tumor by affecting Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 23:5691–5698. 2019.PubMed/NCBI

19 

R Core Team, . A language and environment for statistical computingVienna, Austria: R Foundation for Statistical Computing; 2014

20 

Rivera MN and Haber DA: Wilms' tumour: Connecting tumorigenesis and organ development in the kidney. Nat Rev Cancer. 5:699–712. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Hamilton TE and Shamberger RC: Wilms tumor: Recent advances in clinical care and biology. Semin Pediatr Surg. 21:15–20. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Irtan S, Ehrlich PF and Pritchard-Jones K: Wilms tumor: ‘State-of-the-art’ update, 2016. Semin Pediatr Surg. 25:250–256. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Nakayama DK and Bonasso PC: The history of multimodal treatment of Wilms' tumor. Am Surg. 82:487–492. 2016.PubMed/NCBI

24 

Zhu S, Fu W, Zhang L, Fu K, Hu J, Jia W and Liu G: LINC00473 antagonizes the tumour suppressor miR-195 to mediate the pathogenesis of Wilms tumour via IKKα. Cell Prolif. 512018.doi: 10.1111/cpr.12416.

25 

Mitra SA, Mitra AP and Triche TJ: A central role for long non-coding RNA in cancer. Front Genet. 3:172012. View Article : Google Scholar : PubMed/NCBI

26 

Prensner JR and Chinnaiyan AM: The emergence of lncRNAs in cancer biology. Cancer Discov. 1:391–407. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Martens-Uzunova ES, Böttcher R, Croce CM, Jenster G, Visakorpi T and Calin GA: Long noncoding RNA in prostate, bladder, and kidney cancer. Eur Urol. 65:1140–1151. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Wang M, Zhou L, Yu F, Zhang Y, Li P and Wang K: The functional roles of exosomal long non-coding RNAs in cancer. Cell Mol Life Sci. 76:2059–2076. 2019. View Article : Google Scholar : PubMed/NCBI

29 

de Fatima Silva F, Ortiz-Silva M, Galia WBS, Cassolla P, de Silva FG, Graciano MFR, Carpinelli AR and de Souza HM: Effects of metformin on insulin resistance and metabolic disorders in tumor-bearing rats with advanced cachexia. Can J Physiol Pharmacol. 96:498–505. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Hage-Sleiman R, Herveau S, Matera EL, Laurier JF and Dumontet C: Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells. BMC Cancer. 10:1352010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ren P and Hu M: A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor. Oncol Lett 18: 6164-6170, 2019.
APA
Ren, P., & Hu, M. (2019). A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor. Oncology Letters, 18, 6164-6170. https://doi.org/10.3892/ol.2019.10990
MLA
Ren, P., Hu, M."A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor". Oncology Letters 18.6 (2019): 6164-6170.
Chicago
Ren, P., Hu, M."A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor". Oncology Letters 18, no. 6 (2019): 6164-6170. https://doi.org/10.3892/ol.2019.10990
Copy and paste a formatted citation
x
Spandidos Publications style
Ren P and Hu M: A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor. Oncol Lett 18: 6164-6170, 2019.
APA
Ren, P., & Hu, M. (2019). A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor. Oncology Letters, 18, 6164-6170. https://doi.org/10.3892/ol.2019.10990
MLA
Ren, P., Hu, M."A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor". Oncology Letters 18.6 (2019): 6164-6170.
Chicago
Ren, P., Hu, M."A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor". Oncology Letters 18, no. 6 (2019): 6164-6170. https://doi.org/10.3892/ol.2019.10990
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team