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SPINK1 is a prognosis predicting factor of non‑small cell lung cancer and regulates redox homeostasis

  • Authors:
    • Maoqing Guo
    • Xuan Zhou
    • Xiao Han
    • Youwen Zhang
    • Luning Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China, Department of Critical Care Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6899-6908
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    Published online on: October 18, 2019
       https://doi.org/10.3892/ol.2019.11005
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Abstract

Serine protease inhibitor Kazal‑type 1 (SPINK1) is a trypsin kinase inhibitor, which is involved in the development of inflammation, cell proliferation and cancer development and progression. However, the prognostic value of SPINK1 in non‑small cell lung cancer (NSCLC) and its ability to regulate intrinsic redox homeostasis have, to the best of our knowledge, not been previously investigated. In the present study, it was revealed that SPINK1 is highly expressed in NSCLC tissue samples compared with normal tissue samples, and may be a potential prognostic marker of NSCLC. Functional analyses demonstrated that SPINK1 promoted tumor cell growth and inhibited apoptosis through maintaining redox homeostasis by regulating the nuclear factor erythroid 2‑related factor 2 pathways. It has been proposed that SPINK1 could be a prognostic marker of NSCLC and a novel antioxidant promoter under oxidative stress conditions in NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Guo M, Zhou X, Han X, Zhang Y and Jiang L: SPINK1 is a prognosis predicting factor of non‑small cell lung cancer and regulates redox homeostasis. Oncol Lett 18: 6899-6908, 2019.
APA
Guo, M., Zhou, X., Han, X., Zhang, Y., & Jiang, L. (2019). SPINK1 is a prognosis predicting factor of non‑small cell lung cancer and regulates redox homeostasis. Oncology Letters, 18, 6899-6908. https://doi.org/10.3892/ol.2019.11005
MLA
Guo, M., Zhou, X., Han, X., Zhang, Y., Jiang, L."SPINK1 is a prognosis predicting factor of non‑small cell lung cancer and regulates redox homeostasis". Oncology Letters 18.6 (2019): 6899-6908.
Chicago
Guo, M., Zhou, X., Han, X., Zhang, Y., Jiang, L."SPINK1 is a prognosis predicting factor of non‑small cell lung cancer and regulates redox homeostasis". Oncology Letters 18, no. 6 (2019): 6899-6908. https://doi.org/10.3892/ol.2019.11005
Copy and paste a formatted citation
x
Spandidos Publications style
Guo M, Zhou X, Han X, Zhang Y and Jiang L: SPINK1 is a prognosis predicting factor of non‑small cell lung cancer and regulates redox homeostasis. Oncol Lett 18: 6899-6908, 2019.
APA
Guo, M., Zhou, X., Han, X., Zhang, Y., & Jiang, L. (2019). SPINK1 is a prognosis predicting factor of non‑small cell lung cancer and regulates redox homeostasis. Oncology Letters, 18, 6899-6908. https://doi.org/10.3892/ol.2019.11005
MLA
Guo, M., Zhou, X., Han, X., Zhang, Y., Jiang, L."SPINK1 is a prognosis predicting factor of non‑small cell lung cancer and regulates redox homeostasis". Oncology Letters 18.6 (2019): 6899-6908.
Chicago
Guo, M., Zhou, X., Han, X., Zhang, Y., Jiang, L."SPINK1 is a prognosis predicting factor of non‑small cell lung cancer and regulates redox homeostasis". Oncology Letters 18, no. 6 (2019): 6899-6908. https://doi.org/10.3892/ol.2019.11005
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