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Article

Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma

  • Authors:
    • Yanxia Jiang
    • Jian Chen
    • Guoan Chen
  • View Affiliations / Copyright

    Affiliations: Hematology Department, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China
  • Pages: 6787-6794
    |
    Published online on: October 21, 2019
       https://doi.org/10.3892/ol.2019.11012
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Abstract

Long noncoding RNAs (lncRNAs) are aberrantly expressed in a variety of cancer types. The lncRNA IGF1R antisense imprinted non‑protein coding RNA (IRAIN) is associated with various cancer types, yet the role of IRAIN in multiple myeloma (MM) progression remains unclear. In the present study it was identified that IRAIN may act as a tumor suppressor in MM, whilst microRNA (miR)‑125b may promote tumorigenesis. Downregulation of IRAIN significantly increased the expression of miR‑125b. Furthermore, by using dual‑luciferase reporter assays, IRAIN was identified as a target of miR‑125b. Knockdown of IRAIN promoted MM cell proliferation in vitro. Thus, expression levels of IRAIN may be used to predict the clinical prognosis of patients with MM and may be a novel therapeutic target for treating MM.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang Y, Chen J and Chen G: Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma. Oncol Lett 18: 6787-6794, 2019.
APA
Jiang, Y., Chen, J., & Chen, G. (2019). Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma. Oncology Letters, 18, 6787-6794. https://doi.org/10.3892/ol.2019.11012
MLA
Jiang, Y., Chen, J., Chen, G."Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma". Oncology Letters 18.6 (2019): 6787-6794.
Chicago
Jiang, Y., Chen, J., Chen, G."Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma". Oncology Letters 18, no. 6 (2019): 6787-6794. https://doi.org/10.3892/ol.2019.11012
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Chen J and Chen G: Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma. Oncol Lett 18: 6787-6794, 2019.
APA
Jiang, Y., Chen, J., & Chen, G. (2019). Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma. Oncology Letters, 18, 6787-6794. https://doi.org/10.3892/ol.2019.11012
MLA
Jiang, Y., Chen, J., Chen, G."Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma". Oncology Letters 18.6 (2019): 6787-6794.
Chicago
Jiang, Y., Chen, J., Chen, G."Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma". Oncology Letters 18, no. 6 (2019): 6787-6794. https://doi.org/10.3892/ol.2019.11012
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