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Article Open Access

Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study

  • Authors:
    • Laila M. Sherief
    • Tamer H. Hassan
    • Marwa Zakaria
    • Manar Fathy
    • Elia A. Eshak
    • Marwa A. Bebars
    • Asmaa Esh
  • View Affiliations / Copyright

    Affiliations: Pediatric Oncology Unit, Zagazig University, Zagazig 44519, Arab Republic of Egypt, Department of Pathology, Cairo University, Cairo 11956, Arab Republic of Egypt, Department of Clinical Pathology, Zagazig University, Zagazig 44519, Arab Republic of Egypt
    Copyright: © Sherief et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6347-6354
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    Published online on: October 30, 2019
       https://doi.org/10.3892/ol.2019.11021
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Abstract

Previous studies have revealed that the processes of tumor angiogenesis, metastasis and invasiveness are highly dependent on components of the blood coagulation cascade. Tissue factor (TF) is one of the key proteins in coagulation. Cumulative evidence suggested that in addition to its role in coagulation, TF regulates intracellular signaling pathways that serve an important role in angiogenesis, tumor development and metastasis. In the present study, TF expression in neuroblastoma as well as its association with tumor stage, pathology and outcome were assessed. A total of 40 formalin‑fixed paraffin‑embedded tissues were evaluated for TF expression by immunohistochemical analysis. Results revealed that TF expression was positive in 75% of the analyzed tumor tissues. No significant association between TF expression and sex, age, tumor stage or disease pathology was observed. MYCN proto‑oncogene bHLH transcription factor (MYCN) was upregulated in 45% (n=18) of the study cases. Positive TF expression was observed in 94.4% of patients (n=17) with upregulated MYCN, while 59% of patients (n=13) with normal MYCN showed positive TF expression (P<0.05). TF expression was a significant outcome predictor for patients; 18/30 patients (60%) with positive TF expression succumbed to the disease during the study period. In conclusion, TF may be a promising prognosis indicator for neuroblastoma. Future studies to determine how TF affects the progression and outcome of neuroblastoma, as well as to investigate its potential role as a therapeutic target, are required.
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Copy and paste a formatted citation
Spandidos Publications style
Sherief LM, Hassan TH, Zakaria M, Fathy M, Eshak EA, Bebars MA and Esh A: Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study. Oncol Lett 18: 6347-6354, 2019.
APA
Sherief, L.M., Hassan, T.H., Zakaria, M., Fathy, M., Eshak, E.A., Bebars, M.A., & Esh, A. (2019). Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study. Oncology Letters, 18, 6347-6354. https://doi.org/10.3892/ol.2019.11021
MLA
Sherief, L. M., Hassan, T. H., Zakaria, M., Fathy, M., Eshak, E. A., Bebars, M. A., Esh, A."Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study". Oncology Letters 18.6 (2019): 6347-6354.
Chicago
Sherief, L. M., Hassan, T. H., Zakaria, M., Fathy, M., Eshak, E. A., Bebars, M. A., Esh, A."Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study". Oncology Letters 18, no. 6 (2019): 6347-6354. https://doi.org/10.3892/ol.2019.11021
Copy and paste a formatted citation
x
Spandidos Publications style
Sherief LM, Hassan TH, Zakaria M, Fathy M, Eshak EA, Bebars MA and Esh A: Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study. Oncol Lett 18: 6347-6354, 2019.
APA
Sherief, L.M., Hassan, T.H., Zakaria, M., Fathy, M., Eshak, E.A., Bebars, M.A., & Esh, A. (2019). Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study. Oncology Letters, 18, 6347-6354. https://doi.org/10.3892/ol.2019.11021
MLA
Sherief, L. M., Hassan, T. H., Zakaria, M., Fathy, M., Eshak, E. A., Bebars, M. A., Esh, A."Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study". Oncology Letters 18.6 (2019): 6347-6354.
Chicago
Sherief, L. M., Hassan, T. H., Zakaria, M., Fathy, M., Eshak, E. A., Bebars, M. A., Esh, A."Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study". Oncology Letters 18, no. 6 (2019): 6347-6354. https://doi.org/10.3892/ol.2019.11021
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