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High hnRNP AB expression is associated with poor prognosis in patients with colorectal cancer

  • Authors:
    • Jun‑Min Zhou
    • Hang Jiang
    • Tao Yuan
    • Guang‑Xun Zhou
    • Xiang‑Bing Li
    • Kun‑Ming Wen
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6459-6468
    |
    Published online on: November 1, 2019
       https://doi.org/10.3892/ol.2019.11034
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Abstract

Heterogeneous ribonucleoprotein AB (hnRNP AB) is a member of the heterogeneous nuclear ribonucleoprotein family, which serves important functions in gene expression and signal transduction. However, the expression and clinicopathological significance of hnRNP AB in colorectal cancer (CRC) remain to be elucidated. To investigate the expression and clinical significance of hnRNP AB in CRC, hnRNP AB expression levels were analysed in two independent cohorts of patients with CRC. The results of reverse transcription‑quantitative PCR, immunohistochemistry and western blot analysis demonstrated that hnRNP AB was upregulated in CRC tissues compared with the corresponding adjacent normal tissues. Immunohistochemical analyses indicated that a high expression of hnRNP AB was significantly associated with preoperative carcinoembryonic antigen (CEA; P<0.001) and carbohydrate antigen 19‑9 (P=0.014) levels, tumour size (P=0.022) and infiltration (P=0.026), lymph node metastasis (P<0.001) and Tumour‑Node‑Metastasis stage (P<0.001). Univariate and multivariate Cox survival analyses revealed that hnRNP AB expression and preoperative CEA levels were significant independent factors affecting overall survival in patients with CRC (P<0.05). According to the Kaplan‑Meier model, patients with CRC with high hnRNP AB expression exhibited significantly poorer prognosis compared with those with low hnRNP AB expression (P<0.001). In conclusion, the results of the present study demonstrated that hnRNP AB expression may serve an important role in the progression of CRC and that hnRNP AB may be considered a predictor of prognosis for patients with CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou JM, Jiang H, Yuan T, Zhou GX, Li XB and Wen KM: High hnRNP AB expression is associated with poor prognosis in patients with colorectal cancer. Oncol Lett 18: 6459-6468, 2019.
APA
Zhou, J., Jiang, H., Yuan, T., Zhou, G., Li, X., & Wen, K. (2019). High hnRNP AB expression is associated with poor prognosis in patients with colorectal cancer. Oncology Letters, 18, 6459-6468. https://doi.org/10.3892/ol.2019.11034
MLA
Zhou, J., Jiang, H., Yuan, T., Zhou, G., Li, X., Wen, K."High hnRNP AB expression is associated with poor prognosis in patients with colorectal cancer". Oncology Letters 18.6 (2019): 6459-6468.
Chicago
Zhou, J., Jiang, H., Yuan, T., Zhou, G., Li, X., Wen, K."High hnRNP AB expression is associated with poor prognosis in patients with colorectal cancer". Oncology Letters 18, no. 6 (2019): 6459-6468. https://doi.org/10.3892/ol.2019.11034
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou JM, Jiang H, Yuan T, Zhou GX, Li XB and Wen KM: High hnRNP AB expression is associated with poor prognosis in patients with colorectal cancer. Oncol Lett 18: 6459-6468, 2019.
APA
Zhou, J., Jiang, H., Yuan, T., Zhou, G., Li, X., & Wen, K. (2019). High hnRNP AB expression is associated with poor prognosis in patients with colorectal cancer. Oncology Letters, 18, 6459-6468. https://doi.org/10.3892/ol.2019.11034
MLA
Zhou, J., Jiang, H., Yuan, T., Zhou, G., Li, X., Wen, K."High hnRNP AB expression is associated with poor prognosis in patients with colorectal cancer". Oncology Letters 18.6 (2019): 6459-6468.
Chicago
Zhou, J., Jiang, H., Yuan, T., Zhou, G., Li, X., Wen, K."High hnRNP AB expression is associated with poor prognosis in patients with colorectal cancer". Oncology Letters 18, no. 6 (2019): 6459-6468. https://doi.org/10.3892/ol.2019.11034
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