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Case Report Open Access

An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report

  • Authors:
    • Man Gao
    • Hui Pang
    • Young Mi Kim
    • Xianglan Lu
    • Xianfu Wang
    • Jiyun Lee
    • Mingwei Wang
    • Fanzheng Meng
    • Shibo Li
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma, OK 73104, USA, Clinical Medical College of Beihua University, Jilin City, Jilin 132013, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6725-6731
    |
    Published online on: November 1, 2019
       https://doi.org/10.3892/ol.2019.11035
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Abstract

Translocation (9;11)(p21.3;q23.3) is one of the most common lysine methyltransferase 2A (KMT2A)‑rearrangements in de novo and therapy‑related acute myeloid leukemia (AML). Numerous in vitro and in vivo studies have demonstrated that the KMT2A/MLLT3 super elongation complex subunit (MLLT3) fusion gene on the derivative chromosome 11 serves a crucial role in leukemogenesis. Trisomy 9 as a secondary chromosome change in patients with t(9;11) is relatively rare. The present study reported a unique case of AML with a chromosome 9 trisomy secondary to t(9;11)(p21.3;q23.3) through the cytogenetic analysis of leukemic blood and bone marrow. Further characterization with fluorescence in situ hybridization and array comparative genomic hybridization analysis revealed that this extra chromosome 9 was either a copy of normal chromosome 9 or a derivative chromosome 9. Conversely with the previously reported favorable outcome of AML patients with t(9;11)(p21.3;q23.3), in the present study, the cells with only translocation persisted, whereas the cells with an extra chromosome 9 disappeared following initial chemotherapy. With this unique case, the present study hypothesized that the extra chromosome 9 could serve a crucial role in AML disease progression and contribute to cellular sensitivity to chemotherapy.
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1 

Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M and vardiman JW: The 2016 revision to world health organization classification of myeloid neoplasms and acute leukemia. Blood. 127:2391–2405. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Meyer C, Schneider B, Reichel M, Angermuneller S, Strehl S, Schnittger S, Schoch C, Jansen MW, van Dongen JJ, Pieters R, et al: Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci USA. 102:449–454. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Meyer C, Kowarz E, Hofmann J, Rennevilla A, Zuna J, Trka J, Ben Abdelali R, Macintyre E, De Braekeleer E, De Braekeleer M, et al: New insights to the MLL recombinome of acute leukemias. Leukemia. 23:1490–1499. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Meyer C, Hofmann J, Burmeister T, Gröger D, Park TS, Emerenciano M, Pombo de Oliveira M, Renneville A, Villarese P, Macintyre E, et al: The MLL recombinome of acute leukemias in 2013. Leukemia. 27:2165–2176. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Meyer C, Burmeister T, Gröger D, Tsaur G, Fechina L, Renneville A, Sutton R, Venn NC, Emerenciano M, Pombo-de-Oliveira MS, et al: The MLL recombinome of acute leukemias in 2017. Leukemia. 32:273–284. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Asou N: Myeloid neoplasms in the world health organization 2016 classification. Rinsho Ketsueki. 58:2178–2187. 2017.(In Japanese). PubMed/NCBI

7 

Biondi A, Cimino G, Pieters R and Pui CH: Biological and therapeutic aspects of infant leukemia. Blood. 96:24–33. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Corral J, Lavenir I, Impey H, Warren AJ, Forster A, Larson TA, Bell S, McKenzie AN, King G and Rabbitts TH: An MLL-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes. Cell. 85:853–861. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Dobson CL, Warren AJ, Pannel R, Forster A, Lavenir I, Corral J, Smith AJ and Rabbitts TH: The MLL-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. EMBO J. 18:3564–3574. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Somervaille TC and Cleary ML: Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell. 10:257–268. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Anguita E, Barrio CG, González FA, Ferro MT, del Potro E, Ropero P and Villegas A: Association of t(9;11)-MLL AF9 and trisomy 8 in an AML-M5 preceded by pancytopenia. Cancer Genet Cytogenet. 120:144–147. 2000. View Article : Google Scholar : PubMed/NCBI

12 

McGowan-Jordan J, Simons A and Schmid M: ISCN 2016: An International System for Human Cytogenomic NomenclatureReprint of Cytogenetic and Genome Research. 149. 1st. Karger Publishers; Basel, Switzerland: 2016

13 

Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, et al: Transformation from committed progenitor to leukemia stem cell initiated by MLL-AF9. Nature. 442:818–822. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Schneidawind C, Jeong J, Schneidawind D, Kim IS, Duque-Afonso J, Wong SHK, Iwasaki M, Breese EH, Zehnder JL, Porteus M and Cleary ML: MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing. Blood Adv. 2:832–845. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Bredeson CN, Barnett MJ, Horsman DE, Dalal BI, Ragaz J and Phillips GL: Therapy-related acute myologenous leukemia associated with 11q23 chromosomal abnormalities and topoisomerase II inhibitors: Report of four additional cases and brief commentary. Leuk Lymphoma. 11:141–145. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Langer T, Metzler M, Reinhardt D, Viehmann S, Borkhardt A, Reichel M, Stanulla M, Schrappe M, Creutzig U, Ritter J, et al: Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: Almost identical MLL breakpoints in therapy-related AML after treatment without etoposides. Genes Chromosomes Cancer. 36:393–401. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Chandra P, Luthra R, Zuo Z, Yao H, Ravandi F, Reddy N, Garcia-Manero G, Kantarjian H and Jones D: Acute myeloid leukemia with t(9;11)(p21-22;q23): Common properties of dysregulated ras pathway signaling and genomic progression characterize de novo and therapy-related cases. Am J Clin Pathol. 133:686–693. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Strick R, Strissel PL, Borgers S, Smith SL and Rowley JD: Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc Natl Acad Sci USA. 97:4790–4795. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Bariar B, Vestal CG, Deem B, Goodenow D, Ughetta M, Engledove RW, Sahyouni M and Richardson C: Bioflavonoids promote stable translocation between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks. Environ Mol Mutagen. 60:154–167. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Strissel PL, Strick R, Tomek RJ, Roe BA, Rowley JD and Zeleznik-Le NJ: DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis. Hum Mol Genet. 9:1671–1679. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Johansson B, Moorman AV and Secker-Walker LM: Derivative chromosomes of 11q23-translocations in hematologic malignancies. European 11q23 Workshop participants. Leukemia. 12:828–833. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Krauter J, Peter W, Pascheberg U, Heinze B, Bergmann L, Hoelzer D, Lübbert M, Schlimok G, Arnold R, Kirchner H, et al: Detection of karyotypic aberrations in acute myeloblastic leukaemia: A prospective comparison between PCR/FISH and standard cytogenetics in 140 patients with de novo AML. Br J Haematol. 103:72–78. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Mrózek K, Heinonen K, Lawrence D, Carroll AJ, Koduru PR, Rao KW, Strout MP, Hutchison RE, Moore JO, Mayer RJ, et al: Adult patient with de novo acute myeloid leukemia and t(9;11)(p22;q23) have a superior outcome to patient with other translocation involving band 11q23: A cancer and leukemia group B study. Blood. 90:4532–4538. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Rubnitz JE, Raimondi SC, Tong X, Srivastava DK, Razzouk BI, Shurtleff SA, Downing JR, Pui CH, Ribeiro RC and Behm FG: Favorable impact of the t(9;11) in childhood acute myeloid leukemia. J Clin Oncol. 20:2302–2309. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Balgobind BV, Raimondi SC, Harbott J, Zimmermann M, Alonzo TA, Auvrignon A, Beverloo HB, Chang M, Creutzig U, Dworzak MN, et al: Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: Results of an international retrospective study. Blood. 114:2489–2496. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Stӧlzel F, Mohr B, Kramer M, Oelschlӓgel U, Bochtler T, Berdel WE, Kaufmann M, Baldus CD, Schӓfer-Eckart K, Stuhlmann R, et al: Karyotype complexity and prognosis in acute myeloid leukemia. Blood Cancer J. 6:e3862016. View Article : Google Scholar : PubMed/NCBI

27 

Pession A, Martino V, Tonelli R, Beltramini C, Locatelli F, Biserni G, Franzoni M, Freccero F, Montemrro L, Pattacini L and Paolucci G: MLL-AF9 oncogene expression affects cell growth but not terminal differentiation and is downregulated during monocyte-macrophage maturation in AML-M5 THP-1 cells. Oncogene. 22:8671–8676. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Sambani C, La Starza R, Roumier C, Crescenzi B, Stavropoulou C, Katsarou O Karafoulidou A, Dhalle JH, Lai JL, Preudhomme C, et al: Partial duplication of the MLL oncogene in patients with aggressive acute myeloid leukemia. Haematologica. 89:403–407. 2004.PubMed/NCBI

29 

Andreeva SV, Drozdova VD and Kavardakova NV: Phenomenon of the evolution of clonal chromosomal abnormalities in childhood acute myeloid leukemia. Tsitol Genet. 44:41–52. 2010.(In Russian). PubMed/NCBI

30 

Li M, Wen L, Cen J, Feng Y and Chen S: JAK2V617F allele burden in patients with myeloproliferative neoplasms carrying trisomy 9 and its relationship with clinical phenotypes. Int J Hematol. 103:599–601. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gao M, Pang H, Kim YM, Lu X, Wang X, Lee J, Wang M, Meng F and Li S: An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report. Oncol Lett 18: 6725-6731, 2019.
APA
Gao, M., Pang, H., Kim, Y.M., Lu, X., Wang, X., Lee, J. ... Li, S. (2019). An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report. Oncology Letters, 18, 6725-6731. https://doi.org/10.3892/ol.2019.11035
MLA
Gao, M., Pang, H., Kim, Y. M., Lu, X., Wang, X., Lee, J., Wang, M., Meng, F., Li, S."An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report". Oncology Letters 18.6 (2019): 6725-6731.
Chicago
Gao, M., Pang, H., Kim, Y. M., Lu, X., Wang, X., Lee, J., Wang, M., Meng, F., Li, S."An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report". Oncology Letters 18, no. 6 (2019): 6725-6731. https://doi.org/10.3892/ol.2019.11035
Copy and paste a formatted citation
x
Spandidos Publications style
Gao M, Pang H, Kim YM, Lu X, Wang X, Lee J, Wang M, Meng F and Li S: An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report. Oncol Lett 18: 6725-6731, 2019.
APA
Gao, M., Pang, H., Kim, Y.M., Lu, X., Wang, X., Lee, J. ... Li, S. (2019). An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report. Oncology Letters, 18, 6725-6731. https://doi.org/10.3892/ol.2019.11035
MLA
Gao, M., Pang, H., Kim, Y. M., Lu, X., Wang, X., Lee, J., Wang, M., Meng, F., Li, S."An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report". Oncology Letters 18.6 (2019): 6725-6731.
Chicago
Gao, M., Pang, H., Kim, Y. M., Lu, X., Wang, X., Lee, J., Wang, M., Meng, F., Li, S."An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report". Oncology Letters 18, no. 6 (2019): 6725-6731. https://doi.org/10.3892/ol.2019.11035
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