Open Access

An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report

  • Authors:
    • Man Gao
    • Hui Pang
    • Young Mi Kim
    • Xianglan Lu
    • Xianfu Wang
    • Jiyun Lee
    • Mingwei Wang
    • Fanzheng Meng
    • Shibo Li
  • View Affiliations

  • Published online on: November 1, 2019     https://doi.org/10.3892/ol.2019.11035
  • Pages: 6725-6731
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Translocation (9;11)(p21.3;q23.3) is one of the most common lysine methyltransferase 2A (KMT2A)‑rearrangements in de novo and therapy‑related acute myeloid leukemia (AML). Numerous in vitro and in vivo studies have demonstrated that the KMT2A/MLLT3 super elongation complex subunit (MLLT3) fusion gene on the derivative chromosome 11 serves a crucial role in leukemogenesis. Trisomy 9 as a secondary chromosome change in patients with t(9;11) is relatively rare. The present study reported a unique case of AML with a chromosome 9 trisomy secondary to t(9;11)(p21.3;q23.3) through the cytogenetic analysis of leukemic blood and bone marrow. Further characterization with fluorescence in situ hybridization and array comparative genomic hybridization analysis revealed that this extra chromosome 9 was either a copy of normal chromosome 9 or a derivative chromosome 9. Conversely with the previously reported favorable outcome of AML patients with t(9;11)(p21.3;q23.3), in the present study, the cells with only translocation persisted, whereas the cells with an extra chromosome 9 disappeared following initial chemotherapy. With this unique case, the present study hypothesized that the extra chromosome 9 could serve a crucial role in AML disease progression and contribute to cellular sensitivity to chemotherapy.
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December-2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Gao M, Pang H, Kim YM, Lu X, Wang X, Lee J, Wang M, Meng F and Li S: An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report. Oncol Lett 18: 6725-6731, 2019
APA
Gao, M., Pang, H., Kim, Y.M., Lu, X., Wang, X., Lee, J. ... Li, S. (2019). An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report. Oncology Letters, 18, 6725-6731. https://doi.org/10.3892/ol.2019.11035
MLA
Gao, M., Pang, H., Kim, Y. M., Lu, X., Wang, X., Lee, J., Wang, M., Meng, F., Li, S."An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report". Oncology Letters 18.6 (2019): 6725-6731.
Chicago
Gao, M., Pang, H., Kim, Y. M., Lu, X., Wang, X., Lee, J., Wang, M., Meng, F., Li, S."An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report". Oncology Letters 18, no. 6 (2019): 6725-6731. https://doi.org/10.3892/ol.2019.11035