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Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia

  • Authors:
    • Zhihui Guan
    • Yuwei Song
    • Jinguo Ma
    • Feng Li
    • Xiaojun Zhao
    • Guodong Liang
    • Haiquan An
    • Jinxian Pu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Pediatrics, Hulunbuir People's Hospital, Hulunbuir, Inner Mongolia 021008, P.R. China, Department of Oncology, Hulunbuir People's Hospital, Hulunbuir, Inner Mongolia 021008, P.R. China, Department of Pathology, Hulunbuir People's Hospital, Hulunbuir, Inner Mongolia 021008, P.R. China, Department of Urology, Hulunbuir People's Hospital, Hulunbuir, Inner Mongolia 021008, P.R. China
    Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6379-6384
    |
    Published online on: November 1, 2019
       https://doi.org/10.3892/ol.2019.11039
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Abstract

Long non‑coding (lnc)RNA NCK1 antisense RNA 1 (NCK1‑AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown. It was revealed in the present study that plasma NCK1‑AS1 was upregulated in patients with PC when compared with patients with benign prostatic hyperplasia (BPH) and healthy controls. Upregulation of NCK1‑AS1 distinguished patients with PC from patients with BPH and healthy controls. Overexpression of NCK1‑AS1 led to significantly upregulated transforming growth factor (TGF)‑β1, while TGF‑β1 overexpression failed to significantly affect NCK1‑AS1 in PC cells. NCK1‑AS1 overexpression led to promoted migration and invasion. TGF‑β inhibitor played an opposite role and attenuated the effects of NCK1‑AS1 overexpression. Therefore, NCK1‑AS1 may upregulate TGF‑β1 to promote PC.
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Copy and paste a formatted citation
Spandidos Publications style
Guan Z, Song Y, Ma J, Li F, Zhao X, Liang G, An H and Pu J: Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia. Oncol Lett 18: 6379-6384, 2019.
APA
Guan, Z., Song, Y., Ma, J., Li, F., Zhao, X., Liang, G. ... Pu, J. (2019). Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia. Oncology Letters, 18, 6379-6384. https://doi.org/10.3892/ol.2019.11039
MLA
Guan, Z., Song, Y., Ma, J., Li, F., Zhao, X., Liang, G., An, H., Pu, J."Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia". Oncology Letters 18.6 (2019): 6379-6384.
Chicago
Guan, Z., Song, Y., Ma, J., Li, F., Zhao, X., Liang, G., An, H., Pu, J."Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia". Oncology Letters 18, no. 6 (2019): 6379-6384. https://doi.org/10.3892/ol.2019.11039
Copy and paste a formatted citation
x
Spandidos Publications style
Guan Z, Song Y, Ma J, Li F, Zhao X, Liang G, An H and Pu J: Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia. Oncol Lett 18: 6379-6384, 2019.
APA
Guan, Z., Song, Y., Ma, J., Li, F., Zhao, X., Liang, G. ... Pu, J. (2019). Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia. Oncology Letters, 18, 6379-6384. https://doi.org/10.3892/ol.2019.11039
MLA
Guan, Z., Song, Y., Ma, J., Li, F., Zhao, X., Liang, G., An, H., Pu, J."Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia". Oncology Letters 18.6 (2019): 6379-6384.
Chicago
Guan, Z., Song, Y., Ma, J., Li, F., Zhao, X., Liang, G., An, H., Pu, J."Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia". Oncology Letters 18, no. 6 (2019): 6379-6384. https://doi.org/10.3892/ol.2019.11039
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