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Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report

  • Authors:
    • Nobumichi Takeuchi
    • Kumiko Koike
    • Sonomi Yoshida
    • Masayuki Fujiwara
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Ina Central Hospital, Ina, Nagano 396‑8555, Japan, Department of Clinical Pathology, Ina Central Hospital, Ina, Nagano 396‑8555, Japan
    Copyright: © Takeuchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6469-6474
    |
    Published online on: November 4, 2019
       https://doi.org/10.3892/ol.2019.11043
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Abstract

Recent therapeutic advancements have prolonged the survival duration of patients with metastatic or recurrent colorectal cancer even during salvage treatment. Although treatment with regorafenib and trifluridine/tipiracil combination has exhibited apparent survival benefits, clear and objective evidence of a response to these drugs is scarce. Herein, the present study reports the case of a patient with rectal cancer refractory to multiple surgical interventions and standard chemotherapy. Treatment with regorafenib resulted in immediate improvement of respiratory failure caused by pulmonary lymphangitic carcinomatosis. This improvement persisted for over 3 months and was confirmed by radiology. Our findings suggest that regorafenib can reduce peritumoral edema via its interaction with the vascular endothelial growth factor receptor. Thus, regorafenib functions as a multityrosine kinase inhibitor to alleviate symptoms of lymphangitic carcinomatosis despite the low potency of the drug.
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1 

Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, Humblet Y, Bouché O, Mineur L, Barone C, et al: Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 381:303–312. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Li J, Qin S, Xu R, Yau TC, Ma B, Pan H, Xu J, Bai Y, Chi Y, Wang L, et al: Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): A randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 16:619–629. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Mayer RJ, Van Cutsem E, Falcone A, Yoshino T, Garcia-Carbonero R, Mizunuma N, Yamazaki K, Shimada Y, Tabernero J, Komatsu Y, et al: Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med. 372:1909–1919. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Xu J, Kim TW, Shen L, Sriuranpong V, Pan H, Xu R, Guo W, Han SW, Liu T, Park YS, et al: Results of a randomized, double-blind, placebo-controlled, Phase III trial of trifluridine/tipiracil (TAS-102) monotherapy in Asian patients with previously treated metastatic colorectal cancer: The TERRA study. J Clin Oncol. 36:350–358. 2018. View Article : Google Scholar : PubMed/NCBI

5 

National Collaborating Centre for Chronic Conditions, . Chronic obstructive pulmonary disease: National clinical guideline for management of chronic obstructive pulmonary disease in adults in primary and secondary care. Thorax. 59 (Suppl 1):S1–S232. 2004.

6 

Andrassy KM: Comments on KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 84:622–623. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Van Cutsem E, Martinelli E, Cascinu S, Sobrero A, Banzi M, Seitz JF, Barone C, Ychou M, Peeters M, Brenner B, et al: Regorafenib for patients with metastatic colorectal cancer who progressed after standard therapy: Results of the large, single-arm, open-label phase IIIb CONSIGN study. Oncologist. 24:185–192. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Ramaswamy A, Ostwal V, Pande N, Sharma A, Patil S, Thippeswamy R, Ghadyalpatil N, Roy R, Peshwe H, Poladia B, et al: Practice patterns and outcomes with the use of regorafenib in metastatic colorectal cancer: Results from the Regorafenib in metastatic colorectal cancer-an Indian Exploratory analysis study. South Asian J Cancer. 8:22–26. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Bekaii-Saab TS, Ou FS, Ahn DH, Boland PM, Ciombor KK, Heying EN, Dockter TJ, Jacobs NL, Pasche BC, Cleary JM, et al: Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): A randomised, multicentre, open-label, phase 2 study. Lancet Oncol. 20:1070–1082. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New reponse evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Euro J Cancer. 45:228–247. 2009. View Article : Google Scholar

11 

Yoshino T, Komatsu Y, Yamada Y, Yamazaki K, Tsuji A, Ura T, Grothey A, Van Cutsem E, Wagner A, Cihon F, et al: Randomized phase III trial of regorafenib in metastatic colorectal cancer: Analysis of the CORRECT Japanese and non-Japanese subpopulations. Invest New Drugs. 33:740–750. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Ricotta R, Verrioli A, Ghezzi S, Porcu L, Grothey A, Falcone A, Van Cutsem E, Argilés G, Adenis A, Ychou M, et al: Radiological imaging markers predicting clinical outcome in patients with metastatic colorectal carcinoma treated with regorafenib: Post hoc analysis of the CORRECT phase III trial (RadioCORRECT study). ESMO Open. 1:e0001112017. View Article : Google Scholar : PubMed/NCBI

13 

Nishino M, Cryer SK, Okajima Y, Sholl LM, Hatabu H, Rabin MS, Jackman DM and Johnson BE: Tumoral cavitation in patients with non-small-cell lung cancer treated with antiangiogenic therapy using bevacizumab. Cancer Imaging. 12:225–235. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Boonsirikamchai P, Asran MA, Maru DM, Vauthey JN, Kaur H, Kopetz S and Loyer EM: CT findings of response and recurrence, independent of change in tumor size, in colorectal liver metastasis treated with bevacizumab. AJR Am J Roentgenol. 197:W1060–W1066. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Lim Y, Han SW, Yoon JH, Lee JM, Lee JM, Paeng JC, Won JK, Kang GH, Jeong SY, Park KJ, et al: Clinical implication of anti-angiogenic effect of regorafenib in metastatic colorectal cancer. PLoS One. 10:e01450042015. View Article : Google Scholar : PubMed/NCBI

16 

Chandler GN and Telling M: Lymphangitis carcinomatosa. Br Med J. 2:639–641. 1952. View Article : Google Scholar : PubMed/NCBI

17 

Thomas A and Lenox R: Pulmonary lymphangitic carcinomatosis as a primary manifestation of colon cancer in a young adult. CMAJ. 179:338–340. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Bruce DM, Heys SD and Eremin O: Lymphangitis carcinomatosa: A literature review. J R Coll Surg Edinb. 41:7–13. 1996.PubMed/NCBI

19 

Cyran CC, Kazmierczak PM, Hirner H, Moser M, Ingrisch M, Havla L, Michels A, Eschbach R, Schwarz B, Reiser MF, et al: Regorafenib effects on human colon carcinoma xenografts monitored by dynamic contrast-enhanced computed tomography with immunohistochemical validation. PLoS One. 8:e760092013. View Article : Google Scholar : PubMed/NCBI

20 

Wilhelm SM, Dumas J, Adnane L, Lynch M, Carter CA, Schütz G, Thierauch KH and Zopf D: Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer. 129:245–255. 2011. View Article : Google Scholar : PubMed/NCBI

21 

He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, Harding T, Jooss K, Takahashi T and Alitalo K: Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res. 65:4739–4746. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Shimizu K, Kubo H, Yamaguchi K, Kawashima K, Ueda Y, Matsuo K, Awane M, Shimahara Y, Takabayashi A, Yamaoka Y and Satoh S: Suppression of VEGFR-3 signaling inhibits lymph node metastasis in gastric cancer. Cancer Sci. 95:328–333. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Bekaii-Saab T, Kim R, Kim TW, O'Connor JM, Strickler JH, Malka D, Sartore-Bianchi A, Bi F, Yamaguchi K, Yoshino T and Prager GW: Third- or later-line therapy for metastatic colorectal cancer: Reviewing best practice. Clin Colorectal Cancer. 18:e117–e129. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Schultheis B, Folprecht G, Kuhlmann J, Ehrenberg R, Hacker UT, Köhne CH, Kornacker M, Boix O, Lettieri J, Krauss J, et al: Regorafenib in combination with FOLFOX or FOLFIRI as first- or second-line treatment of colorectal cancer: Results of a multicenter, phase Ib study. Ann Oncol. 24:1560–1567. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Takeuchi N, Koike K, Yoshida S and Fujiwara M: Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report. Oncol Lett 18: 6469-6474, 2019.
APA
Takeuchi, N., Koike, K., Yoshida, S., & Fujiwara, M. (2019). Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report. Oncology Letters, 18, 6469-6474. https://doi.org/10.3892/ol.2019.11043
MLA
Takeuchi, N., Koike, K., Yoshida, S., Fujiwara, M."Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report". Oncology Letters 18.6 (2019): 6469-6474.
Chicago
Takeuchi, N., Koike, K., Yoshida, S., Fujiwara, M."Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report". Oncology Letters 18, no. 6 (2019): 6469-6474. https://doi.org/10.3892/ol.2019.11043
Copy and paste a formatted citation
x
Spandidos Publications style
Takeuchi N, Koike K, Yoshida S and Fujiwara M: Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report. Oncol Lett 18: 6469-6474, 2019.
APA
Takeuchi, N., Koike, K., Yoshida, S., & Fujiwara, M. (2019). Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report. Oncology Letters, 18, 6469-6474. https://doi.org/10.3892/ol.2019.11043
MLA
Takeuchi, N., Koike, K., Yoshida, S., Fujiwara, M."Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report". Oncology Letters 18.6 (2019): 6469-6474.
Chicago
Takeuchi, N., Koike, K., Yoshida, S., Fujiwara, M."Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report". Oncology Letters 18, no. 6 (2019): 6469-6474. https://doi.org/10.3892/ol.2019.11043
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