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Article Open Access

YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway

  • Authors:
    • Haibin Liu
    • Dong Mei
    • Pengcheng Xu
    • Haisheng Wang
    • Yan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, China‑Japan Friendship Hospital, Beijing 100029, P.R. China, Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, Beijing 100045, P.R. China, Department of Pharmaceutical Engineering, College of Pharmacy, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6752-6758
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    Published online on: November 4, 2019
       https://doi.org/10.3892/ol.2019.11049
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Abstract

Yes‑associated protein (YAP) has been reported to serve an important role in gastric cancer cell survival and migration. However, the underlying mechanism remains unclear. The aim of present study was to identify the underlying mechanism through which Yap sustains gastric cancer viability and migration. The results of the present study demonstrated that YAP expression was upregulated in gastric cancer MKN‑28/74 cells compared with normal gastric GES‑1 cells. Functional studies revealed that silencing of YAP inhibited gastric cancer MKN‑28/74 cell viability and invasion. Mechanistically, YAP may promote gastric cancer cell survival and migration/invasion by inhibiting the endoplasmic reticulum (ER) stress pathway. In addition, YAP may regulate ER stress by activating the ERK signaling pathway. The results of the present study suggested that YAP may be a tumor promoter in gastric cancer and act through the ERK/ER stress pathway; therefore, YAP may have potential implications for new approaches to gastric cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Liu H, Mei D, Xu P, Wang H and Wang Y: YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway. Oncol Lett 18: 6752-6758, 2019.
APA
Liu, H., Mei, D., Xu, P., Wang, H., & Wang, Y. (2019). YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway. Oncology Letters, 18, 6752-6758. https://doi.org/10.3892/ol.2019.11049
MLA
Liu, H., Mei, D., Xu, P., Wang, H., Wang, Y."YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway". Oncology Letters 18.6 (2019): 6752-6758.
Chicago
Liu, H., Mei, D., Xu, P., Wang, H., Wang, Y."YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway". Oncology Letters 18, no. 6 (2019): 6752-6758. https://doi.org/10.3892/ol.2019.11049
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Mei D, Xu P, Wang H and Wang Y: YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway. Oncol Lett 18: 6752-6758, 2019.
APA
Liu, H., Mei, D., Xu, P., Wang, H., & Wang, Y. (2019). YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway. Oncology Letters, 18, 6752-6758. https://doi.org/10.3892/ol.2019.11049
MLA
Liu, H., Mei, D., Xu, P., Wang, H., Wang, Y."YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway". Oncology Letters 18.6 (2019): 6752-6758.
Chicago
Liu, H., Mei, D., Xu, P., Wang, H., Wang, Y."YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway". Oncology Letters 18, no. 6 (2019): 6752-6758. https://doi.org/10.3892/ol.2019.11049
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