Open Access

YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway

  • Authors:
    • Haibin Liu
    • Dong Mei
    • Pengcheng Xu
    • Haisheng Wang
    • Yan Wang
  • View Affiliations

  • Published online on: November 4, 2019     https://doi.org/10.3892/ol.2019.11049
  • Pages: 6752-6758
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Yes‑associated protein (YAP) has been reported to serve an important role in gastric cancer cell survival and migration. However, the underlying mechanism remains unclear. The aim of present study was to identify the underlying mechanism through which Yap sustains gastric cancer viability and migration. The results of the present study demonstrated that YAP expression was upregulated in gastric cancer MKN‑28/74 cells compared with normal gastric GES‑1 cells. Functional studies revealed that silencing of YAP inhibited gastric cancer MKN‑28/74 cell viability and invasion. Mechanistically, YAP may promote gastric cancer cell survival and migration/invasion by inhibiting the endoplasmic reticulum (ER) stress pathway. In addition, YAP may regulate ER stress by activating the ERK signaling pathway. The results of the present study suggested that YAP may be a tumor promoter in gastric cancer and act through the ERK/ER stress pathway; therefore, YAP may have potential implications for new approaches to gastric cancer therapy.
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December-2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu H, Mei D, Xu P, Wang H and Wang Y: YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway. Oncol Lett 18: 6752-6758, 2019
APA
Liu, H., Mei, D., Xu, P., Wang, H., & Wang, Y. (2019). YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway. Oncology Letters, 18, 6752-6758. https://doi.org/10.3892/ol.2019.11049
MLA
Liu, H., Mei, D., Xu, P., Wang, H., Wang, Y."YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway". Oncology Letters 18.6 (2019): 6752-6758.
Chicago
Liu, H., Mei, D., Xu, P., Wang, H., Wang, Y."YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway". Oncology Letters 18, no. 6 (2019): 6752-6758. https://doi.org/10.3892/ol.2019.11049