Combination of contrast‑enhanced ultrasound and strain elastography to assess cytologically non‑diagnostic thyroid nodules

  • Authors:
    • Zi‑Mei Lin
    • Qing Wen
    • Cao‑Xin Yan
    • Min‑Qiang Pan
    • Guo‑Qiang Mo
    • Ji‑Fan Chen
    • Pin‑Tong Huang
  • View Affiliations

  • Published online on: November 5, 2019     https://doi.org/10.3892/ol.2019.11058
  • Pages: 6845-6851
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Abstract

The aim of the present study was to investigate the benefits of combining contrast‑enhanced ultrasound (CEUS) and strain elastography (SE) for the diagnosis of thyroid nodules with non‑diagnostic fine‑needle aspiration cytology (FNAC) results. Between October 2013 and March 2017, CEUS and SE were performed in 226 patients (236 thyroid nodules) with non‑diagnostic FNAC results prior to thyroidectomy. The diagnostic value of CEUS, SE and their combination (CEUS+SE) in distinguishing malignant from benign thyroid nodules was evaluated, using surgical pathology as a reference. Receiver operating characteristic curve analysis was used to assess the diagnostic performance of CEUS, SE and CEUS+SE in determining malignant thyroid nodules. Subsequently, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of CEUS, SE and CEUS + SE were calculated. The malignancy rate in patients with thyroid nodules and non‑diagnostic FNAC results was 26.3% in the present study. The sensitivity, specificity, PPV, NPV, accuracy and area under the curve in predicting malignant thyroid nodules were 80.6, 85.6, 66.7, 92.5, 84.3 and 0.831%, respectively, using SE alone; 59.7, 95.9, 84.1, 86.9, 86.4 and 0.778%, respectively, using CEUS alone; and 83.9, 89.1, 73.6, 94.5, 88.1 and 0.865%, respectively, using the combination of CEUS and SE. Overall, the combination of CEUS with SE resulted in higher sensitivity, NPV and accuracy in the diagnosis of cytologically non‑diagnostic thyroid nodules compared with CEUS or SE alone.
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December-2019
Volume 18 Issue 6

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Spandidos Publications style
Lin ZM, Wen Q, Yan CX, Pan MQ, Mo GQ, Chen JF and Huang PT: Combination of contrast‑enhanced ultrasound and strain elastography to assess cytologically non‑diagnostic thyroid nodules. Oncol Lett 18: 6845-6851, 2019
APA
Lin, Z., Wen, Q., Yan, C., Pan, M., Mo, G., Chen, J., & Huang, P. (2019). Combination of contrast‑enhanced ultrasound and strain elastography to assess cytologically non‑diagnostic thyroid nodules. Oncology Letters, 18, 6845-6851. https://doi.org/10.3892/ol.2019.11058
MLA
Lin, Z., Wen, Q., Yan, C., Pan, M., Mo, G., Chen, J., Huang, P."Combination of contrast‑enhanced ultrasound and strain elastography to assess cytologically non‑diagnostic thyroid nodules". Oncology Letters 18.6 (2019): 6845-6851.
Chicago
Lin, Z., Wen, Q., Yan, C., Pan, M., Mo, G., Chen, J., Huang, P."Combination of contrast‑enhanced ultrasound and strain elastography to assess cytologically non‑diagnostic thyroid nodules". Oncology Letters 18, no. 6 (2019): 6845-6851. https://doi.org/10.3892/ol.2019.11058