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Upregulation of Holliday junction recognition protein predicts poor prognosis and biochemical recurrence in patients with prostate cancer

  • Authors:
    • Yan‑Fei Chen
    • Yu‑Xiang Liang
    • Jian‑An Yang
    • Dao‑Zhang Yuan
    • Jing Li
    • Shun‑Sheng Zheng
    • Yue‑Ping Wan
    • Bin Wang
    • Zhao‑Dong Han
    • Wei‑De Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China, Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China , Department of Urology, Huadu District People's Hospital, Southern Medical University, Guangzhou, Guangdong 510180, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6697-6703
    |
    Published online on: November 5, 2019
       https://doi.org/10.3892/ol.2019.11061
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Abstract

Abnormal expression of Holliday junction recognition protein (HJURP) in several types of tumor cells plays a vital role in the formation and progression of tumors. Few studies have investigated the role of HJURP in prostate cancer (PCa). The aim of this study was to analyze the expression levels of HJURP in PCa and to establish the association with clinicopathological data. Reverse transcription quantitative polymerase chain reaction and immunohistochemical analysis were used to detect the expression levels of HJURP in benign and PCa prostate tissues. The Taylor dataset was statistically analyzed to determine if HJURP expression levels were associated with PCa clinicopathological data. HJURP was overexpressed in PCa tissues compared with benign prostate tissues. Statistical analysis of the Taylor dataset indicated that upregulation of HJURP was significantly associated with positive prostate‑specific antigen (PSA) levels (P=0.004), high Gleason score (P=0.005), advanced pathological stage (P=0.007), metastasis (P<0.001) and PSA failure (P<0.001). Higher HJURP mRNA expression levels were significantly associated with shorter biochemical recurrence (BCR)‑free survival (P<0.001). To the best of our knowledge, this study is the first report of HJURP upregulation in PCa tissues. Upregulation of HJURP may predict BCR‑free survival and HJURP may be an oncogene that impacts the prognosis of patients with PCa.
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Copy and paste a formatted citation
Spandidos Publications style
Chen YF, Liang YX, Yang JA, Yuan DZ, Li J, Zheng SS, Wan YP, Wang B, Han ZD, Zhong WD, Zhong WD, et al: Upregulation of Holliday junction recognition protein predicts poor prognosis and biochemical recurrence in patients with prostate cancer. Oncol Lett 18: 6697-6703, 2019.
APA
Chen, Y., Liang, Y., Yang, J., Yuan, D., Li, J., Zheng, S. ... Zhong, W. (2019). Upregulation of Holliday junction recognition protein predicts poor prognosis and biochemical recurrence in patients with prostate cancer. Oncology Letters, 18, 6697-6703. https://doi.org/10.3892/ol.2019.11061
MLA
Chen, Y., Liang, Y., Yang, J., Yuan, D., Li, J., Zheng, S., Wan, Y., Wang, B., Han, Z., Zhong, W."Upregulation of Holliday junction recognition protein predicts poor prognosis and biochemical recurrence in patients with prostate cancer". Oncology Letters 18.6 (2019): 6697-6703.
Chicago
Chen, Y., Liang, Y., Yang, J., Yuan, D., Li, J., Zheng, S., Wan, Y., Wang, B., Han, Z., Zhong, W."Upregulation of Holliday junction recognition protein predicts poor prognosis and biochemical recurrence in patients with prostate cancer". Oncology Letters 18, no. 6 (2019): 6697-6703. https://doi.org/10.3892/ol.2019.11061
Copy and paste a formatted citation
x
Spandidos Publications style
Chen YF, Liang YX, Yang JA, Yuan DZ, Li J, Zheng SS, Wan YP, Wang B, Han ZD, Zhong WD, Zhong WD, et al: Upregulation of Holliday junction recognition protein predicts poor prognosis and biochemical recurrence in patients with prostate cancer. Oncol Lett 18: 6697-6703, 2019.
APA
Chen, Y., Liang, Y., Yang, J., Yuan, D., Li, J., Zheng, S. ... Zhong, W. (2019). Upregulation of Holliday junction recognition protein predicts poor prognosis and biochemical recurrence in patients with prostate cancer. Oncology Letters, 18, 6697-6703. https://doi.org/10.3892/ol.2019.11061
MLA
Chen, Y., Liang, Y., Yang, J., Yuan, D., Li, J., Zheng, S., Wan, Y., Wang, B., Han, Z., Zhong, W."Upregulation of Holliday junction recognition protein predicts poor prognosis and biochemical recurrence in patients with prostate cancer". Oncology Letters 18.6 (2019): 6697-6703.
Chicago
Chen, Y., Liang, Y., Yang, J., Yuan, D., Li, J., Zheng, S., Wan, Y., Wang, B., Han, Z., Zhong, W."Upregulation of Holliday junction recognition protein predicts poor prognosis and biochemical recurrence in patients with prostate cancer". Oncology Letters 18, no. 6 (2019): 6697-6703. https://doi.org/10.3892/ol.2019.11061
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