Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Definition of a novel vascular invasion‑associated multi‑gene signature for predicting survival in patients with hepatocellular carcinoma

  • Authors:
    • Bo Yi
    • Caixi Tang
    • Yin Tao
    • Zhijian Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Zhu Zhou Central Hospital, Zhuzhou, Hunan 412007, P.R. China
    Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 147-158
    |
    Published online on: November 8, 2019
       https://doi.org/10.3892/ol.2019.11072
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to identify a vascular invasion‑associated gene signature for predicting prognosis in patients with hepatocellular carcinoma (HCC). Using RNA‑sequencing data of 292 HCC samples from The Cancer Genome Atlas (TCGA), the present study screened differentially expressed genes (DEGs) between patients with and without vascular invasion. Feature genes were selected from the DEGs by support vector machine (SVM)‑based recursive feature elimination (RFE‑SVM) algorithm to build a classifier. A multi‑gene signature was selected by L1 penalized (LASSO) Cox proportional hazards (PH) regression model from the feature genes selected by the RFE‑SVM to develop a prognostic scoring model. TCGA set was defined as the training set and was divided by the gene signature into a high‑risk group and a low‑risk group. Involvement of the DEGs between the two risk groups in pathways was also investigated. The presence and absence of vascular invasion between patients of training set was 175 DEGs. A classification model of 42 genes performed well in differentiating patients with and without vascular invasion on the training set and the validation set. A 14‑gene prognostic model was built that could divide the training set or the validation set into two risk groups with significantly different survival outcomes. A total of 762 DEGs in the two risk groups of the training set were revealed to be significantly associated with a number of signaling pathways. The present study provided a 42‑gene classifier for predicting vascular invasion, and identified a vascular invasion‑associated 14‑gene signature for predicting prognosis in patients with HCC. Several genes and pathways in HCC development are characterized and may be potential therapeutic targets for this type of cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Balogh J, Victor D III, Asham EH, Burroughs SG, Boktour M, Saharia A, Li X, Ghobrial RM and Monsour HP Jr: Hepatocellular carcinoma: A review. J Hepatocell Carcinoma. 3:41–53. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Bertuccio P, Turati F, Carioli G, Rodriguez T, La Vecchia C, Malvezzi M and Negri E: Global trends and predictions in hepatocellular carcinoma mortality. J Hepatol. 67:302–309. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Lo YC, Hsu FC, Hung SK, Tseng KC, Hsieh YH, Lee MS, Tseng CW, Lin HY, Chen LC and Chiou WY: Prognosticators of hepatocellular carcinoma with intrahepatic vascular invasion. Ci Ji Yi Xue Za Zhi. 31:40–46. 2019.PubMed/NCBI

4 

Pawlik TM, Poon RT, Abdalla EK, Zorzi D, Ikai I, Curley SA, Nagorney DM, Belghiti J, Ng IO, Yamaoka Y, et al: Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma. Arch Surg. 140:450–458. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Sakata J, Shirai Y, Wakai T, Kaneko K, Nagahashi M and Hatakeyama K: Preoperative predictors of vascular invasion in hepatocellular carcinoma. Eur J Surg Oncol. 34:900–905. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Hsieh CH, Wei CK, Yin WY, Chang CM, Tsai SJ, Wang LY, Chiou WY, Lee MS, Lin HY and Hung SK: Vascular invasion affects survival in early hepatocellular carcinoma. Mol Clin Oncol. 3:252–256. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Hui Z, Chen C, Xu F, Yan X, Jia W, Mao L, Jin H and Qiu Y: Prognostic value of a novel risk classification of microvascular invasion in patients with hepatocellular carcinoma after resection. Oncotarget. 8:5474–5486. 2016.

8 

Ho MC, Lin JJ, Chen CN, Chen CC, Lee H, Yang CY, Ni YH, Chang KJ, Hsu HC, Hsieh FJ and Lee PH: A gene expression profile for vascular invasion can predict the recurrence after resection of hepatocellular carcinoma: A microarray approach. Ann Surg Oncol. 13:1474–1484. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Mínguez B, Hoshida Y, Villanueva A, Toffanin S, Cabellos L, Thung S, Mandeli J, Sia D, April C, Fan JB, et al: Gene-expression signature of vascular invasion in hepatocellular carcinoma. J Hepatol. 55:1325–1331. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Lin Z, Cai YJ, Chen RC, Chen BC, Zhao L, Xu SH, Wang XD, Song M, Wu JM, Wang YQ, et al: A microRNA expression profile for vascular invasion can predict overall survival in hepatocellular carcinoma. Clin Chim Acta. 469:171–179. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Ravishankar H, Madhavan R, Mullick R, Shetty T, Marinelli L and Joel SE: Recursive feature elimination for biomarker discovery in resting-state functional connectivity. Conf Proc IEEE Eng Med Biol Soc. 2016:4071–4074. 2016.PubMed/NCBI

12 

Hoshida Y, Villanueva A, Kobayashi M, Peix J, Chiang DY, Camargo A, Gupta S, Moore J, Wrobel MJ, Lerner J, et al: Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med. 359:1995–2004. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Wang P, Wang Y, Hang B, Zou X and Mao JH: A novel gene expression-based prognostic scoring system to predict survival in gastric cancer. Oncotarget. 7:55343–55351. 2016.PubMed/NCBI

14 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

15 

Eisen MB, Spellman PT, Brown PO and Botstein D: Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA. 95:14863–14868. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Wang L, Cao C, Ma Q, Zeng Q, Wang H, Cheng Z, Zhu G, Qi J, Ma H, Nian H and Wang Y: RNA-seq analyses of multiple meristems of soybean: Novel and alternative transcripts, evolutionary and functional implications. BMC Plant Biol. 14:1692014. View Article : Google Scholar : PubMed/NCBI

17 

Lu X, Yang Y, Wu F, Gao M, Xu Y, Zhang Y, Yao Y, Du X, Li C, Wu L, et al: Discriminative analysis of schizophrenia using support vector machine and recursive feature elimination on structural MRI images. Medicine (Baltimore). 95:e39732016. View Article : Google Scholar : PubMed/NCBI

18 

Deist TM, Dankers FJMM, Valdes G, Wijsman R, Hsu IC, Oberije C, Lustberg T, van Soest J, Hoebers F, Jochems A, et al: Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers. Med Phys. 45:3449–3459. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Wang Q and Liu X: Screening of feature genes in distinguishing different types of breast cancer using support vector machine. Onco Targets Ther. 8:2311–2317. 2015.PubMed/NCBI

20 

Mayr A and Schmid M: Boosting the concordance index for survival data-a unified framework to derive and evaluate biomarker combinations. PLoS One. 9:e844832014. View Article : Google Scholar : PubMed/NCBI

21 

Zhang X, Li Y, Akinyemiju T, Ojesina AI, Buckhaults P, Liu N, Xu B and Yi N: Pathway-structured predictive model for cancer survival prediction: A two-stage approach. Genetics. 205:89–100. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Schroder MS, Culhane AC, Quackenbush J and Haibe-Kains B: Survcomp: An R/Bioconductor package for performance assessment and comparison of survival models. Bioinformatics. 27:3206–3208. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC and Müller M: pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics. 12:772011. View Article : Google Scholar : PubMed/NCBI

24 

Tibshirani R: The lasso method for variable selection in the Cox model. Stat Med. 16:385–395. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Aguirre-Gamboa R, Gomez-Rueda H, Martinez-Ledesma E, Martínez-Torteya A, Chacolla-Huaringa R, Rodriguez- Barrientos A, Tamez-Peña JG and Treviño V: SurvExpress: An online biomarker validation tool and database for cancer gene expression data using survival analysis. PLoS One. 8:e742502013. View Article : Google Scholar : PubMed/NCBI

26 

Hoshida Y, Nijman SM, Kobayashi M, Chan JA, Brunet JP, Chiang DY, Villanueva A, Newell P, Ikeda K, Hashimoto M, et al: Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res. 69:7385–7392. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Varotti G, Ramacciato G, Ercolani G, Grazi GL, Vetrone G, Cescon M, Del Gaudio M, Ravaioli M, Ziparo V, Lauro A and Pinna A: Comparison between the fifth and sixth editions of the AJCC/UICC TNM staging systems for hepatocellular carcinoma: Multicentric study on 393 cirrhotic resected patients. Eur J Surg Oncol. 31:760–767. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Singal AG and El-Serag HB: Hepatocellular carcinoma from epidemiology to prevention: Translating knowledge into practice. Clin Gastroenterol Hepatol. 13:2140–2151. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Kasai Y, Hatano E, Seo S, Taura K, Yasuchika K and Uemoto S: Hepatocellular carcinoma with bile duct tumor thrombus: Surgical outcomes and the prognostic impact of concomitant major vascular invasion. World J Surg. 39:1485–1493. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Ahsani Z, Mohammadi-Yeganeh S, Kia V, Karimkhanloo H, Zarghami N and Paryan M: WNT1 Gene from WNT signaling pathway is a direct target of miR-122 in hepatocellular carcinoma. Appl Biochem Biotechnol. 181:884–897. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Goitre L, Trapani E, Trabalzini L and Retta SF: The Ras superfamily of small GTPases: The unlocked secrets. Methods Mol Biol. 1120:1–18. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Xing X, Huang Y, Wang S, Chi M, Zeng Y, Chen L, Li L, Zeng J, Lin M, Han X, et al: Dataset for the quantitative proteomics analysis of the primary hepatocellular carcinoma with single and multiple lesions. Data Brief. 5:226–240. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Chen J, Zhuo JY, Yang F, Liu ZK, Zhou L, Xie HY, Xu X and Zheng SS: 17-beta-hydroxysteroid dehydrogenase 13 inhibits the progression and recurrence of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 17:220–226. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Su W, Mao Z, Liu Y, Zhang X, Zhang W, Gustafsson JA and Guan Y: Role of HSD17B13 in the liver physiology and pathophysiology. Mol Cell Endocrinol. 489:119–125. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Qiao X, Zhou Y, Xie W, Wang Y, Zhang Y, Tian T, Dou J, Yang X, Shen S, Hu J, et al: Scinderin is a novel transcriptional target of BRMS1 involved in regulation of hepatocellular carcinoma cell apoptosis. Am J Cancer Res. 8:1008–1018. 2018.PubMed/NCBI

37 

Ribatti D, Marzullo A, Gentile A, Longo V, Nico B, Vacca A and Dammacco F: Erythropoietin/erythropoietin-receptor system is involved in angiogenesis in human hepatocellular carcinoma. Histopathology. 50:591–596. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Yang Z, Sun B, Zhao X, Shao B, An J, Gu Q, Wang Y, Dong X, Zhang Y and Qiu Z: Erythropoietin and erythropoietin receptor in hepatocellular carcinoma: Correlation with vasculogenic mimicry and poor prognosis. Int J Clin Exp Pathol. 8:4033–4043. 2015.PubMed/NCBI

39 

Miao S, Wang SM, Cheng X, Li YF, Zhang QS, Li G, He SQ, Chen XP and Wu P: Erythropoietin promoted the proliferation of hepatocellular carcinoma through hypoxia induced translocation of its specific receptor. Cancer Cell Int. 17:1192017. View Article : Google Scholar : PubMed/NCBI

40 

Ng KT, Qi X, Kong KL, Cheung BY, Lo CM, Poon RT, Fan ST and Man K: Overexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinoma. Eur J Cancer. 47:2299–2305. 2011. View Article : Google Scholar : PubMed/NCBI

41 

He MK, Le Y, Zhang YF, Ouyang HY, Jian PE, Yu ZS, Wang LJ and Shi M: Matrix metalloproteinase 12 expression is associated with tumor FOXP3+ regulatory T cell infiltration and poor prognosis in hepatocellular carcinoma. Oncol Lett. 16:475–482. 2018.PubMed/NCBI

42 

Cambiaghi V, Giuliani V, Lombardi S, Marinelli C, Toffalorio F and Pelicci PG: TRIM proteins in cancer. Adv Exp Med Biol. 770:77–91. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Guo Y, Peng Y, Gao D, Zhang M, Yang W, Linghu E, Herman JG, Fuks F, Dong G and Guo M: Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma. Clin Epigenetics. 9:1162017. View Article : Google Scholar : PubMed/NCBI

44 

Ho DW, Kai AK and Ng IO: TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma. Front Med. 9:322–330. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Shirakami Y, Sakai H and Shimizu M: Retinoid roles in blocking hepatocellular carcinoma. Hepatobiliary Surg Nutr. 4:222–228. 2015.PubMed/NCBI

46 

Yan T, Lu L, Xie C, Chen J, Peng X, Zhu L, Wang Y, Li Q, Shi J, Zhou F, et al: Severely impaired and dysregulated cytochrome P450 expression and activities in hepatocellular carcinoma: Implications for personalized treatment in patients. Mol Cancer Ther. 14:2874–2886. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Fanale D, Amodeo V and Caruso S: The interplay between metabolism, PPAR signaling pathway, and cancer. PPAR Res. 2017:18306262017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yi B, Tang C, Tao Y and Zhao Z: Definition of a novel vascular invasion‑associated multi‑gene signature for predicting survival in patients with hepatocellular carcinoma. Oncol Lett 19: 147-158, 2020.
APA
Yi, B., Tang, C., Tao, Y., & Zhao, Z. (2020). Definition of a novel vascular invasion‑associated multi‑gene signature for predicting survival in patients with hepatocellular carcinoma. Oncology Letters, 19, 147-158. https://doi.org/10.3892/ol.2019.11072
MLA
Yi, B., Tang, C., Tao, Y., Zhao, Z."Definition of a novel vascular invasion‑associated multi‑gene signature for predicting survival in patients with hepatocellular carcinoma". Oncology Letters 19.1 (2020): 147-158.
Chicago
Yi, B., Tang, C., Tao, Y., Zhao, Z."Definition of a novel vascular invasion‑associated multi‑gene signature for predicting survival in patients with hepatocellular carcinoma". Oncology Letters 19, no. 1 (2020): 147-158. https://doi.org/10.3892/ol.2019.11072
Copy and paste a formatted citation
x
Spandidos Publications style
Yi B, Tang C, Tao Y and Zhao Z: Definition of a novel vascular invasion‑associated multi‑gene signature for predicting survival in patients with hepatocellular carcinoma. Oncol Lett 19: 147-158, 2020.
APA
Yi, B., Tang, C., Tao, Y., & Zhao, Z. (2020). Definition of a novel vascular invasion‑associated multi‑gene signature for predicting survival in patients with hepatocellular carcinoma. Oncology Letters, 19, 147-158. https://doi.org/10.3892/ol.2019.11072
MLA
Yi, B., Tang, C., Tao, Y., Zhao, Z."Definition of a novel vascular invasion‑associated multi‑gene signature for predicting survival in patients with hepatocellular carcinoma". Oncology Letters 19.1 (2020): 147-158.
Chicago
Yi, B., Tang, C., Tao, Y., Zhao, Z."Definition of a novel vascular invasion‑associated multi‑gene signature for predicting survival in patients with hepatocellular carcinoma". Oncology Letters 19, no. 1 (2020): 147-158. https://doi.org/10.3892/ol.2019.11072
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team