Expression and function of long non‑coding RNA LINC01420 in thyroid cancer

Luo,Jin‑Zhu; Qin,Lu; Zhang,Ling‑Jie

doi:10.3892/ol.2019.11076

Expression and function of long non‑coding RNA LINC01420 in thyroid cancer

Authors:
- Jin‑Zhu Luo
- Lu Qin
- Ling‑Jie Zhang
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Affiliations: Department of Clinical Laboratory, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, Hubei 434020, P.R. China, Department of Thyroid Vascular Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, Hubei 434020, P.R. China, Department of Anesthesiology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, Hubei 430015, P.R. China
Published online on: November 11, 2019 https://doi.org/10.3892/ol.2019.11076
Pages: 399-405
Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The Human Genome Project revealed that >90% of the human genome was found to transcribe non‑coding RNAs, including micro RNAs and long non‑coding RNAs (lncRNAs). lncRNAs have been identified to play a crucial role in cancer progression. Thyroid cancer (TC) is a common type of endocrine cancer; however, the functional roles of lncRNAs in TC have yet to be fully elucidated. The present study investigated whether LINC01420 was upregulated in TC tissues, compared with normal thyroid tissues, and the results suggested that LINC01420 may play a regulatory role in TC. Bioinformatics analysis demonstrated that LINC01420 was associated with translation, rRNA processing, mRNA splicing, regulation of transcription, DNA repair and double‑strand break repair. Furthermore, the exact role of LINC01420 in TC was explored by performing a loss‑of‑function assay, which revealed that the knockdown of LINC01420 inhibited TC cell proliferation and cell cycle progression. The findings of the present study provide a novel insight into the molecular mechanisms underlying TC development. Moreover, they suggest that LINC01420 may serve as a potential therapeutic target for the treatment of TC, and that increased LINC01420 expression levels show potential as a prognostic marker for the disease.

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