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Article

p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer

  • Authors:
    • Ge Yu
    • Na Li
    • Wei Wang
    • Ming Niu
    • Xiaoling Feng
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China, Department of Gynecology, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China
  • Pages: 505-512
    |
    Published online on: November 13, 2019
       https://doi.org/10.3892/ol.2019.11081
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Abstract

The non‑ATPase regulatory subunit 10 of the human 26S proteasome (p28GANK) has been implicated in the tumorigenesis and progression of several types of malignant tumor. The aim of the present study was to detect the expression of p28GANK in ovarian cancer (OC) and investigate its association with the clinicopathological features and prognosis of OC. The expression levels of p28GANK were determined in 114 OC tissue samples and 30 normal ovarian tissue samples using immunohistochemistry. An association was observed between p28GANK overexpression and certain clinicopathological factors, including advanced International Federation of Gynecology and Obstetrics stage (P=0.042), residual tumor size (P=0.005) and response to chemotherapy (P<0.001). Furthermore, patients with high expression of p28GANK demonstrated worse overall survival (OS) and disease‑free survival (DFS) rates compared with patients with low expression of p28GANK (both P<0.001). Multivariate Cox regression analysis revealed that overexpression of p28GANK was an independent prognostic factor of OS and DFS in patients with OC (P=0.013 and P=0.001, respectively). In summary, the current results indicate that p28GANK may be a predictive marker and a therapeutic target for OC.
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Copy and paste a formatted citation
Spandidos Publications style
Yu G, Li N, Wang W, Niu M and Feng X: p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer. Oncol Lett 19: 505-512, 2020.
APA
Yu, G., Li, N., Wang, W., Niu, M., & Feng, X. (2020). p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer. Oncology Letters, 19, 505-512. https://doi.org/10.3892/ol.2019.11081
MLA
Yu, G., Li, N., Wang, W., Niu, M., Feng, X."p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer". Oncology Letters 19.1 (2020): 505-512.
Chicago
Yu, G., Li, N., Wang, W., Niu, M., Feng, X."p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer". Oncology Letters 19, no. 1 (2020): 505-512. https://doi.org/10.3892/ol.2019.11081
Copy and paste a formatted citation
x
Spandidos Publications style
Yu G, Li N, Wang W, Niu M and Feng X: p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer. Oncol Lett 19: 505-512, 2020.
APA
Yu, G., Li, N., Wang, W., Niu, M., & Feng, X. (2020). p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer. Oncology Letters, 19, 505-512. https://doi.org/10.3892/ol.2019.11081
MLA
Yu, G., Li, N., Wang, W., Niu, M., Feng, X."p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer". Oncology Letters 19.1 (2020): 505-512.
Chicago
Yu, G., Li, N., Wang, W., Niu, M., Feng, X."p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer". Oncology Letters 19, no. 1 (2020): 505-512. https://doi.org/10.3892/ol.2019.11081
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