p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer

  • Authors:
    • Ge Yu
    • Na Li
    • Wei Wang
    • Ming Niu
    • Xiaoling Feng
  • View Affiliations

  • Published online on: November 13, 2019     https://doi.org/10.3892/ol.2019.11081
  • Pages: 505-512
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The non‑ATPase regulatory subunit 10 of the human 26S proteasome (p28GANK) has been implicated in the tumorigenesis and progression of several types of malignant tumor. The aim of the present study was to detect the expression of p28GANK in ovarian cancer (OC) and investigate its association with the clinicopathological features and prognosis of OC. The expression levels of p28GANK were determined in 114 OC tissue samples and 30 normal ovarian tissue samples using immunohistochemistry. An association was observed between p28GANK overexpression and certain clinicopathological factors, including advanced International Federation of Gynecology and Obstetrics stage (P=0.042), residual tumor size (P=0.005) and response to chemotherapy (P<0.001). Furthermore, patients with high expression of p28GANK demonstrated worse overall survival (OS) and disease‑free survival (DFS) rates compared with patients with low expression of p28GANK (both P<0.001). Multivariate Cox regression analysis revealed that overexpression of p28GANK was an independent prognostic factor of OS and DFS in patients with OC (P=0.013 and P=0.001, respectively). In summary, the current results indicate that p28GANK may be a predictive marker and a therapeutic target for OC.
View Figures
View References

Related Articles

Journal Cover

January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yu G, Li N, Wang W, Niu M and Feng X: p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer. Oncol Lett 19: 505-512, 2020
APA
Yu, G., Li, N., Wang, W., Niu, M., & Feng, X. (2020). p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer. Oncology Letters, 19, 505-512. https://doi.org/10.3892/ol.2019.11081
MLA
Yu, G., Li, N., Wang, W., Niu, M., Feng, X."p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer". Oncology Letters 19.1 (2020): 505-512.
Chicago
Yu, G., Li, N., Wang, W., Niu, M., Feng, X."p28GANK overexpression is associated with chemotherapy resistance and poor prognosis in ovarian cancer". Oncology Letters 19, no. 1 (2020): 505-512. https://doi.org/10.3892/ol.2019.11081