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Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study

  • Authors:
    • Xiaoling Shang
    • Jiamao Lin
    • Zhenxiang Li
    • Haiyong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Internal Medicine‑Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China
    Copyright: © Shang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 139-146
    |
    Published online on: November 14, 2019
       https://doi.org/10.3892/ol.2019.11092
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Abstract

The aim of the present study was to investigate the prognostic impact of RT on patients with extensive stage small cell lung cancer (ES‑SCLC) and distant metastasis. Using the Surveillance Epidemiology and End Results (SEER) database, 8,595 patients with ES‑SCLC exhibiting distant metastasis treated between 2010 and 2013 were identified. Patient baseline characteristics were compared using the χ2 test. The Kaplan‑Meier test was used to analyze subgroup cancer‑specific survival (CSS) rate, and differences were compared using a log‑rank test. Univariate and multivariate Cox regression models were used to analyze the prognostic variables on CSS. RT was determined to be an independent prognostic factor for patient CSS (P<0.001). In addition, RT could improve the CSS of patients with ES‑SCLC with one metastatic lesion (hazard ratio, 0.63; 95% confidence interval, 0.59‑0.68; P<0.001), including the bone, brain, liver and lung metastatic sites. However, for patients with two metastatic sites, RT did not improve CSS regardless of metastasis pattern (all P>0.05). To conclude, RT may improve the survival rate of patients with ES‑SCLC with distant metastasis, particularly in those with only one metastatic site.
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Copy and paste a formatted citation
Spandidos Publications style
Shang X, Lin J, Li Z and Wang H: Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study. Oncol Lett 19: 139-146, 2020.
APA
Shang, X., Lin, J., Li, Z., & Wang, H. (2020). Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study. Oncology Letters, 19, 139-146. https://doi.org/10.3892/ol.2019.11092
MLA
Shang, X., Lin, J., Li, Z., Wang, H."Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study". Oncology Letters 19.1 (2020): 139-146.
Chicago
Shang, X., Lin, J., Li, Z., Wang, H."Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study". Oncology Letters 19, no. 1 (2020): 139-146. https://doi.org/10.3892/ol.2019.11092
Copy and paste a formatted citation
x
Spandidos Publications style
Shang X, Lin J, Li Z and Wang H: Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study. Oncol Lett 19: 139-146, 2020.
APA
Shang, X., Lin, J., Li, Z., & Wang, H. (2020). Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study. Oncology Letters, 19, 139-146. https://doi.org/10.3892/ol.2019.11092
MLA
Shang, X., Lin, J., Li, Z., Wang, H."Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study". Oncology Letters 19.1 (2020): 139-146.
Chicago
Shang, X., Lin, J., Li, Z., Wang, H."Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study". Oncology Letters 19, no. 1 (2020): 139-146. https://doi.org/10.3892/ol.2019.11092
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