Open Access

Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study

  • Authors:
    • Xiaoling Shang
    • Jiamao Lin
    • Zhenxiang Li
    • Haiyong Wang
  • View Affiliations

  • Published online on: November 14, 2019     https://doi.org/10.3892/ol.2019.11092
  • Pages: 139-146
  • Copyright: © Shang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the prognostic impact of RT on patients with extensive stage small cell lung cancer (ES‑SCLC) and distant metastasis. Using the Surveillance Epidemiology and End Results (SEER) database, 8,595 patients with ES‑SCLC exhibiting distant metastasis treated between 2010 and 2013 were identified. Patient baseline characteristics were compared using the χ2 test. The Kaplan‑Meier test was used to analyze subgroup cancer‑specific survival (CSS) rate, and differences were compared using a log‑rank test. Univariate and multivariate Cox regression models were used to analyze the prognostic variables on CSS. RT was determined to be an independent prognostic factor for patient CSS (P<0.001). In addition, RT could improve the CSS of patients with ES‑SCLC with one metastatic lesion (hazard ratio, 0.63; 95% confidence interval, 0.59‑0.68; P<0.001), including the bone, brain, liver and lung metastatic sites. However, for patients with two metastatic sites, RT did not improve CSS regardless of metastasis pattern (all P>0.05). To conclude, RT may improve the survival rate of patients with ES‑SCLC with distant metastasis, particularly in those with only one metastatic site.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shang X, Lin J, Li Z and Wang H: Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study. Oncol Lett 19: 139-146, 2020
APA
Shang, X., Lin, J., Li, Z., & Wang, H. (2020). Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study. Oncology Letters, 19, 139-146. https://doi.org/10.3892/ol.2019.11092
MLA
Shang, X., Lin, J., Li, Z., Wang, H."Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study". Oncology Letters 19.1 (2020): 139-146.
Chicago
Shang, X., Lin, J., Li, Z., Wang, H."Radiotherapy may improve survival of ES‑SCLC with distant metastasis only for patients with one metastatic site: A population‑based study". Oncology Letters 19, no. 1 (2020): 139-146. https://doi.org/10.3892/ol.2019.11092