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Article

Redefining the T1 category of the 8th American Joint Committee on Cancer Staging System for intrahepatic cholangiocarcinoma: A SEER database analysis

  • Authors:
    • Yang Li
    • Chuangang Tang
    • Bingqing Zhao
    • Fang Dong
  • View Affiliations / Copyright

    Affiliations: Hepatobiliary Surgery Department, Organ Transplantation Center, Tianjin First Central Hospital, Tianjin 300192, P.R. China, Department of Breast Surgery, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, Jiangsu 221009, P.R. China, Department of Surgery, Tianjin Second People's Hospital, Tianjin 300192, P.R. China, Vascular Surgery Department, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China
  • Pages: 527-532
    |
    Published online on: November 14, 2019
       https://doi.org/10.3892/ol.2019.11096
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Abstract

The T1 tumor category is further divided into T1a (≤5 cm) and T1b (>5 cm) by tumor size in the 8th edition of the American Joint Committee on Cancer (AJCC) staging system for intrahepatic cholangiocarcinoma (ICC). The aim of the present study was to investigate the association between tumor size and prognosis in patients with T1 ICC. The data regarding patients with ICC was downloaded from the Surveillance, Epidemiology, and End Results database between January 2004 and December 2013, at the time of first diagnosis and entered into the database. Demographic and pathological characteristics of patients were analyzed using an independent t‑test and χ2 test. Overall survival was evaluated using Kaplan‑Meier analysis; the cut‑off point for tumor size was determined using the X‑tile software. A total of 407 patients with ICC were selected from the analysis, including 199 cases with stage IA and 208 cases with stage IB tumors. The independent prognostic factors for patients with stage IA ICC were age and surgery. Independent prognostic factors for patients with stage IB ICC included age, surgery (yes vs. no) and tumor size (5‑7 vs. ≥7 cm). The optimal cut‑off value for tumor size was determined to be ~7 cm using X‑tile software. Tumor size with a cut‑off value of 7 cm could stratify patients by risk better than a value of 5 cm [hazard ratio (HR), 1.775; 95% confidence interval (CI), 1.356‑2.323 and; HR, 1.402; 95% CI, 1.078‑1.824, respectively]. This suggests that the T1 tumor category should be subclassified into T1a and T1b with a cut‑off of 7 cm rather than 5 cm. The next edition of the AJCC staging system may take the present evidence into consideration for improvement regarding the accurate staging of ICC.
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1 

Ikai I, Arii S, Okazaki M, Okita K, Omata M, Kojiro M, Takayasu K, Nakanuma Y, Makuuchi M, Matsuyama Y, et al: Report of the 17th Nationwide Follow-up Survey of Primary Liver Cancer in Japan. Hepatol Res. 37:676–691. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Hu J, Chen FY, Zhou KQ, Zhou C, Cao Y, Sun HC, Fan J, Zhou J and Wang Z: Intrahepatic cholangiocarcinoma patients without indications of lymph node metastasis not benefit from lymph node dissection. Oncotarget. 8:113817–113827. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Aljiffry M, Abdulelah A, Walsh M, Peltekian K, Alwayn I and Molinari M: Evidence-based approach to cholangiocarcinoma: A systematic review of the current literature. J Am Coll Surg. 208:134–147. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Poultsides GA, Zhu AX, Choti MA and Pawlik TM: Intrahepatic cholangiocarcinoma. Surg Clin North Am. 90:817–837. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Lin XH and Luo JC: The risk factors and prognostic factors of intrahepatic cholangiocarcinoma. J Chin Med Assoc. 80:121–122. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR and Winchester DP: The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more ‘personalized’ approach to cancer staging. CA Cancer J Clin. 67:93–99. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Yamashita YI, Shirabe K, Beppu T, Eguchi S, Nanashima A, Ohta M, Ueno S, Kondo K, Kitahara K, Shiraishi M, et al: Surgical management of recurrent intrahepatic cholangiocarcinoma: predictors, adjuvant chemotherapy, and surgical therapy for recurrence: A multi-institutional study by the Kyushu Study Group of Liver Surgery. Ann Gastroenterol Surg. 1:136–142. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Spolverato G, Ejaz A, Kim Y, Sotiropoulos GC, Pau A, Alexandrescu S, Marques H, Pulitano C, Barroso E, Clary BM, et al: Tumor size predicts vascular invasion and histologic grade among patients undergoing resection of intrahepatic cholangiocarcinoma. J Gastrointest Surg. 18:1284–1291. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Fritz A, Percy C, Jack A, Shanmugaratnam K, Sobin L and Parkin DM: International classification of diseases for oncology (ICD-O)3ed. Geneva: World Health Organization; 2013

10 

Lee AJ and Chun YS: Intrahepatic cholangiocarcinoma: The AJCC/UICC 8th edition updates. Chin Clin Oncol. 7:522018. View Article : Google Scholar : PubMed/NCBI

11 

Camp RL, Dolled-Filhart M and Rimm DL: X-tile: A new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 10:7252–7259. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Kim Y, Moris DP, Zhang XF, Bagante F, Spolverato G, Schmidt C, Dilhoff M and Pawlik TM: Evaluation of the 8th edition American Joint Commission on Cancer (AJCC) staging system for patients with intrahepatic cholangiocarcinoma: A surveillance, epidemiology, and end results (SEER) analysis. J Surg Oncol. 116:643–650. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Wang Y, Li J, Xia Y, Gong R, Wang K, Yan Z, Wan X, Liu G, Wu D, Shi L, et al: Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy. J Clin Oncol. 31:1188–1195. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Clark CJ, Wood-Wentz CM, Reid-Lombardo KM, Kendrick ML, Huebner M and Que FG: Lymphadenectomy in the staging and treatment of intrahepatic cholangiocarcinoma: A population-based study using the National Cancer Institute SEER database. HPB (Oxford). 13:612–620. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Bunsiripaiboon P, Sornmayura P, Wilasrusmee C and Lertsithichai P: The prognostic significance of microvessel density in intrahepatic cholangiocarcinoma. J Med Assoc Thai. 93:66–72. 2010.PubMed/NCBI

16 

Tamandl D, Herberger B, Gruenberger B, Puhalla H, Klinger M and Gruenberger T: Influence of hepatic resection margin on recurrence and survival in intrahepatic cholangiocarcinoma. Ann Surg Oncol. 15:2787–2794. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Ribero D, Pinna AD, Guglielmi A, Ponti A, Nuzzo G, Giulini SM, Aldrighetti L, Calise F, Gerunda GE, Tomatis M, et al: Surgical approach for long-term survival of patients with intrahepatic cholangiocarcinoma: A multi-institutional analysis of 434 patients. Arch Surg. 147:1107–1113. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Fisher SB, Patel SH, Kooby DA, Weber S, Bloomston M, Cho C, Hatzaras I, Schmidt C, Winslow E, Staley CA III, et al: Lymphovascular and perineural invasion as selection criteria for adjuvant therapy in intrahepatic cholangiocarcinoma: A multi-institution analysis. HPB (Oxford). 14:514–522. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Hyder O, Marques H, Pulitano C, Marsh JW, Alexandrescu S, Bauer TW, Gamblin TC, Sotiropoulos GC, Paul A, Barroso E, et al: A nomogram to predict long-term survival after resection for intrahepatic cholangiocarcinoma: An Eastern and Western experience. JAMA Surg. 149:432–438. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Tang C, Zhao B and Dong F: Redefining the T1 category of the 8th American Joint Committee on Cancer Staging System for intrahepatic cholangiocarcinoma: A SEER database analysis. Oncol Lett 19: 527-532, 2020.
APA
Li, Y., Tang, C., Zhao, B., & Dong, F. (2020). Redefining the T1 category of the 8th American Joint Committee on Cancer Staging System for intrahepatic cholangiocarcinoma: A SEER database analysis. Oncology Letters, 19, 527-532. https://doi.org/10.3892/ol.2019.11096
MLA
Li, Y., Tang, C., Zhao, B., Dong, F."Redefining the T1 category of the 8th American Joint Committee on Cancer Staging System for intrahepatic cholangiocarcinoma: A SEER database analysis". Oncology Letters 19.1 (2020): 527-532.
Chicago
Li, Y., Tang, C., Zhao, B., Dong, F."Redefining the T1 category of the 8th American Joint Committee on Cancer Staging System for intrahepatic cholangiocarcinoma: A SEER database analysis". Oncology Letters 19, no. 1 (2020): 527-532. https://doi.org/10.3892/ol.2019.11096
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Tang C, Zhao B and Dong F: Redefining the T1 category of the 8th American Joint Committee on Cancer Staging System for intrahepatic cholangiocarcinoma: A SEER database analysis. Oncol Lett 19: 527-532, 2020.
APA
Li, Y., Tang, C., Zhao, B., & Dong, F. (2020). Redefining the T1 category of the 8th American Joint Committee on Cancer Staging System for intrahepatic cholangiocarcinoma: A SEER database analysis. Oncology Letters, 19, 527-532. https://doi.org/10.3892/ol.2019.11096
MLA
Li, Y., Tang, C., Zhao, B., Dong, F."Redefining the T1 category of the 8th American Joint Committee on Cancer Staging System for intrahepatic cholangiocarcinoma: A SEER database analysis". Oncology Letters 19.1 (2020): 527-532.
Chicago
Li, Y., Tang, C., Zhao, B., Dong, F."Redefining the T1 category of the 8th American Joint Committee on Cancer Staging System for intrahepatic cholangiocarcinoma: A SEER database analysis". Oncology Letters 19, no. 1 (2020): 527-532. https://doi.org/10.3892/ol.2019.11096
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