Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Complete radiological response following subtotal resection in three glioblastoma patients under treatment with Tumor Treating Fields

  • Authors:
    • Almuth Friederike Kessler
    • Thomas Linsenmann
    • Thomas Westermaier
    • Wanja Wolber
    • Judith Weiland
    • Camelia‑Maria Monoranu
    • Maria Breun
    • Carsten Hagemann
    • Ralf‑Ingo Ernestus
    • Mario Löhr
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, University Hospital of Würzburg, Würzburg 97080, Germany, Department of Neuropathology, Institute of Pathology, University of Würzburg, Würzburg 97080, Germany
  • Pages: 557-561
    |
    Published online on: November 19, 2019
       https://doi.org/10.3892/ol.2019.11110
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Glioblastoma multiforme (GBM) treatment consists of surgery, radiotherapy and chemotherapy with Temozolomide (TMZ). After subtotal resection (STR), residual tumors rarely undergo spontaneous regression. Overall survival (OS) and progression‑free survival (PFS) are reduced when compared with gross total resection. There is evidence that adding Tumor Treating Fields (TTFields) to standard management may lead to a significant increase in PFS and OS. In 2015 and 2016, STR was performed in 27 patients with GBM. Of these, four subsequently received TTFields therapy in addition to chemotherapy. The present study presents a series of three patients with GBM (44‑54 years; isocitrate dehydrogenase wild-type, methylated O6‑methylguanine‑DNA methyltransferase promoter) that were treated with radiochemotherapy and TTFields after STR. Therapy with TTFields started concomitantly to TMZ following radiotherapy and was maintained for 14, 24 and 37 months. TTFields were used as monotherapy in one case, as TMZ treatment had to be stopped due to toxicity for 1 month. In all patients, TTFields therapy was well tolerated at high compliance levels, resulting in complete response (CR) after 4, 5 and 7 months, respectively. Two patients remain tumor‑free at 16 and 40 months after STR. One patient exhibited multifocal recurrence 11 months after the beginning of TTFields treatment but remains alive, presenting a mild neurological decline 24 months after starting TTFields. All three presented patients gave written informed consent for their data to be published. In conclusion, the current report detailed three patients with GBM who underwent STR and were subsequently treated with TMZ and TTFields. TTFields treatment was tolerated well and was applied accurately and with high compliance by these patients, which may have contributed to the complete response. Four of the 27 patients treated with STR received additional TTFields treatment. Three of these 4 showed a CR, while a CR was observed only 2 of the remaining 23 patients without TTFields. The current series supports the effects in clinical practice, as demonstrated in recent clinical trials. The results also demonstrated that adjuvant TTFields therapy can structurally affect residual tumors after STR.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Kreth FW, Thon N, Simon M, Westphal M, Schackert G, Nikkhah G, Hentschel B, Reifenberger G, Pietsch T, Weller M, et al: Gross total but not incomplete resection of glioblastoma prolongs survival in the era of radiochemotherapy. Ann Oncol. 24:3117–3123. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Sanai N, Polley MY, McDermott MW, Parsa AT and Berger MS: An extent of resection threshold for newly diagnosed glioblastoma. J Neurosurg. 115:3–8. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, et al: A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection, and survival. J Neurosurg. 95:190–198. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Tsitlakidis A, Foroglou N, Venetis CA, Patsalas I, Hatzisotiriou A and Selviaridis P: Biopsy versus resection in the management of malignant gliomas: A systematic review and meta-analysis. J Neurosurg. 112:1020–1032. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Oppenlander ME, Wolf AB, Snyder LA, Bina R, Wilson JR, Coons SW, Ashby LS, Brachman D, Nakaji P, Porter RW, et al: An extent of resection threshold for recurrent glioblastoma and its risk for neurological morbidity. J Neurosurg. 120:846–853. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Kirson ED, Dbalý V, Tovarys F, Vymazal J, Soustiel JF, Itzhaki A, Mordechovich D, Steinberg-Shapira S, Gurvich Z, Schneidermann R, et al: Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors. Proc Natl Acad Sci USA. 104:10152–10157. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Stupp R, Taillibert S, Kanner A, Read W, Steinberg D, Lhermitte B, Toms S, Idbaih A, Ahluwalia MS, Fink K, et al: Effect of tumor-treating fields plus maintenance temozolomide vs. maintenance temozolomide alone on survival in patients with glioblastoma: A Randomized Clinical Trial. JAMA. 318:2306–2316. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Ram Z, Kim CY, Nicholas G and Toms S: Compliance and treatment duration predict survival in a phase EF-14 trial of tumor treating fields with temozolomide in patients with newly diagnosed glioblastoma. Neuro Oncol. 19 (Suppl 6):(6): pp. vi6–vi7. 2017, https://doi.org/10.1093/neuonc/nox168.022 View Article : Google Scholar

9 

Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, Degroot J, Wick W, Gilbert MR, Lassman AB, et al: Updated response assessment criteria for high-grade gliomas: Response assessment in neuro-oncology working group. J Clin Oncol. 28:1963–1972. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Taphoorn MJB, Dirven L, Kanner AA, Lavy-Shahaf G, Weinberg U, Taillibert S, Toms SA, Honnorat J, Chen TC, Sroubek J, et al: Influence of treatment with tumor-treating fields on health-related quality of life of patients with newly diagnosed glioblastoma: A secondary analysis of a randomized clinical trial. JAMA Oncol. 4:495–504. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Stupp R, Wong ET, Kanner AA, Steinberg D, Engelhard H, Heidecke V, Kirson ED, Taillibert S, Liebermann F, Dbalý V, et al: NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality. Eur J Cancer. 48:2192–2202. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Onken J, Staub-Bartelt F, Vajkoczy P and Misch M: Acceptance and compliance of TTFields treatment among high grade glioma patients. J Neurooncol. 139:177–184. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Hemminki K, Liu X, Försti A, Ji J, Sundquist J and Sundquist K: Subsequent brain tumors in patients with autoimmune disease. Neuro Oncol. 15:1142–1150. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Ji J, Shu X, Sundquist K, Sundquist J and Hemminki K: Cancer risk in hospitalised psoriasis patients: A follow-up study in Sweden. Br J Cancer. 100:1499–1502. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Wang Y, Li S, Zhang Z, Chen X, You G, Yang P, Yan W, Bao ZS, Yao K, Wang L, et al: Surgical extent impacts the value of the established prognosticators in glioblastoma patients: A prospective translational study in Asia. Head Neck Oncol. 4:802012.

17 

Beiko J, Suki D, Hess KR, Fox BD, Cheung V, Cabral M, Shonka N, Gilbert MR, Sawaya R, Prabhu SS, et al: IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection. Neuro Oncol. 16:81–91. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Bloch O, Han SJ, Cha S, Sun MZ, Aghi MK, McDermott MW, Berger MS and Parsa AT: Impact of extent of resection for recurrent glioblastoma on overall survival clinical article. J Neurosurg. 117:1032–1038. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Vymazal J and Wong ET: Response patterns of recurrent glioblastomas treated with tumor-treating fields. Semin Oncol. 41 (Suppl 6):S14–S24. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Combs SE, Rieken S, Wick W, Abdollahi A, von Deimling A, Debus J and Hartmann C: Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back? Radiat Oncol. 6:1152011. View Article : Google Scholar : PubMed/NCBI

21 

Millward CP, Brodbelt AR, Haylock B, Zakaria R, Baborie A, Crooks D, Husband D, Shenoy A, Wong H and Jenkinson MD: The impact of MGMT methylation and IDH-1 mutation on long-term outcome for glioblastoma treated with chemoradiotherapy. Acta Neurochir (Wien). 158:1943–1953. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Yang P, Zhang W, Wang Y, Peng X, Chen B, Qiu X, Li G, Li S, Wu C, Yao K, et al: IDH mutation and MGMT promoter methylation in glioblastoma: Results of a prospective registry. Oncotarget. 6:40896–40906. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kessler AF, Linsenmann T, Westermaier T, Wolber W, Weiland J, Monoranu CM, Breun M, Hagemann C, Ernestus RI, Löhr M, Löhr M, et al: Complete radiological response following subtotal resection in three glioblastoma patients under treatment with Tumor Treating Fields. Oncol Lett 19: 557-561, 2020.
APA
Kessler, A.F., Linsenmann, T., Westermaier, T., Wolber, W., Weiland, J., Monoranu, C. ... Löhr, M. (2020). Complete radiological response following subtotal resection in three glioblastoma patients under treatment with Tumor Treating Fields. Oncology Letters, 19, 557-561. https://doi.org/10.3892/ol.2019.11110
MLA
Kessler, A. F., Linsenmann, T., Westermaier, T., Wolber, W., Weiland, J., Monoranu, C., Breun, M., Hagemann, C., Ernestus, R., Löhr, M."Complete radiological response following subtotal resection in three glioblastoma patients under treatment with Tumor Treating Fields". Oncology Letters 19.1 (2020): 557-561.
Chicago
Kessler, A. F., Linsenmann, T., Westermaier, T., Wolber, W., Weiland, J., Monoranu, C., Breun, M., Hagemann, C., Ernestus, R., Löhr, M."Complete radiological response following subtotal resection in three glioblastoma patients under treatment with Tumor Treating Fields". Oncology Letters 19, no. 1 (2020): 557-561. https://doi.org/10.3892/ol.2019.11110
Copy and paste a formatted citation
x
Spandidos Publications style
Kessler AF, Linsenmann T, Westermaier T, Wolber W, Weiland J, Monoranu CM, Breun M, Hagemann C, Ernestus RI, Löhr M, Löhr M, et al: Complete radiological response following subtotal resection in three glioblastoma patients under treatment with Tumor Treating Fields. Oncol Lett 19: 557-561, 2020.
APA
Kessler, A.F., Linsenmann, T., Westermaier, T., Wolber, W., Weiland, J., Monoranu, C. ... Löhr, M. (2020). Complete radiological response following subtotal resection in three glioblastoma patients under treatment with Tumor Treating Fields. Oncology Letters, 19, 557-561. https://doi.org/10.3892/ol.2019.11110
MLA
Kessler, A. F., Linsenmann, T., Westermaier, T., Wolber, W., Weiland, J., Monoranu, C., Breun, M., Hagemann, C., Ernestus, R., Löhr, M."Complete radiological response following subtotal resection in three glioblastoma patients under treatment with Tumor Treating Fields". Oncology Letters 19.1 (2020): 557-561.
Chicago
Kessler, A. F., Linsenmann, T., Westermaier, T., Wolber, W., Weiland, J., Monoranu, C., Breun, M., Hagemann, C., Ernestus, R., Löhr, M."Complete radiological response following subtotal resection in three glioblastoma patients under treatment with Tumor Treating Fields". Oncology Letters 19, no. 1 (2020): 557-561. https://doi.org/10.3892/ol.2019.11110
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team