Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Insight into the effects of microRNA‑23a‑3p on pancreatic cancer and its underlying molecular mechanism

  • Authors:
    • Jiadeng Chao
    • Lei Jin
    • Xudong Zhang
    • Dong Ding
    • Siyuan Wu
    • Le Ma
    • Bei Zhu
    • Shiting Shan
    • Xiao Yun
    • Peng Gao
    • Jun Li
    • Chunfu Zhu
    • Xihu Qin
  • View Affiliations / Copyright

    Affiliations: Department of Pancreatopathy, Pancreas Center of Changzhou Clinical College, Nanjing Medical University, Changzhou, Jiangsu 213003, P.R. China
    Copyright: © Chao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 187-194
    |
    Published online on: November 19, 2019
       https://doi.org/10.3892/ol.2019.11117
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous studies have demonstrated that microRNA (miR)‑23a‑3p plays a role as an oncogene that is involved in several different types of carcinoma. However, few studies investigated the association between miR‑23a‑3p and pancreatic cancer (PC). The aim of the present study was to elucidate the biological functions of miR‑23a‑3p in PC and to investigate its underlying molecular mechanisms. The expression of miR‑23a‑3p in PC and adjacent normal tissues was investigated using microarrays. In order to validate the outcomes of the microarray results, reverse transcription‑quantitative (RT‑q)PCR was used to determine the expression levels of miR‑23a‑3p in PC tissues and cell lines. Furthermore, functional analyses were conducted following miR‑23a‑3p inhibition and overexpression, in order to assess the proliferation, invasion and migration of PC cells. Bioinformatics analysis indicated transforming growth factor‑β receptor type II (TGFBR2) as a potential direct target of miR‑23a‑3p. Western blotting was performed in order to determine the protein expression of TGFBR2 in PC cell lines. The findings from the microarray demonstrated upregulation of miR‑23a‑3p in PC compared with normal tissues. RT‑qPCR revealed significantly higher levels of miR‑23a‑3p expression in PC compared with normal control tissues or cells. Furthermore, miR‑23a‑3p was demonstrated to promote the proliferation, invasion and migration of PC cells, which was suppressed by the inhibition of miR‑23a‑3p. In addition, the miR‑23a‑3p expression level was negatively associated with TGFBR2 expression. Overall, the present study demonstrated the tumor‑promoting effects of miR‑23a‑3p in PC cells. Furthermore, miR‑23a‑3p is a potential oncogenic regulator of PC, by targeting TGFBR2, and a biomarker or target for molecular therapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

US Preventive Services Task Force, ; Owens DK, Davidson KW, Krist AH, Barry MJ, Cabana M, Caughey AB, Curry SJ, Doubeni CA, Epling JW Jr, et al: Screening for pancreatic cancer: US preventive services task force reaffirmation recommendation statement. JAMA. 322:438–444. 2019. View Article : Google Scholar : PubMed/NCBI

2 

McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG and McCain RS: Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes. World J Gastroenterol. 24:4846–4861. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Zhang Y, Yang P and Wang XF: Microenvironmental regulation of cancer metastasis by miRNAs. Trends Cell Biol. 24:153–160. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Tassinari V, Cesarini V, Silvestris DA and Gallo A: The adaptive potential of RNA editing-mediated miRNA-retargeting in cancer. Biochim Biophys Acta Gene Regul Mech. 1862:291–300. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Kwok GT, Zhao JT, Weiss J, Mugridge N, Brahmbhatt H, MacDiarmid JA, Robinson BG and Sidhu SB: Translational applications of microRNAs in cancer, and therapeutic implications. Noncoding RNA Res. 2:143–150. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Frampton AE, Castellano L, Colombo T, Giovannetti E, Krell J, Jacob J, Pellegrino L, Roca-Alonso L, Funel N, Gall TM, et al: MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression. Gastroenterology. 146:268–277.e18. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Zhang L, Gao LG, Zhang M and Zhou XL: Genotype-phenotype analysis of F-helix mutations at the kinase domain of TGFBR2, including a type 2 Marfan syndrome familial study. Mol Vis. 18:55–63. 2012.PubMed/NCBI

8 

Luo J, Chen XQ and Li P: The Role of TGF-β and its receptors in gastrointestinal cancers. Transl Oncol. 12:475–484. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Pu XH, Li F, Miao XL, Ye JL and Lu LG: Transforming growth factor beta regulates hepatic progenitor cells migration via PI3K/AKT/mTOR/p70S6K pathway. Zhonghua Gan Zang Bing Za Zhi. 26:680–685. 2018.(In Chinese). PubMed/NCBI

10 

Zhou H, Wu G, Ma X, Xiao J, Yu G, Yang C, Xu N, Zhang B, Zhou J, Ye Z and Wang Z: Attenuation of TGFBR2 expression and tumour progression in prostate cancer involve diverse hypoxia-regulated pathways. J Exp Clin Cancer Res. 37:892018. View Article : Google Scholar : PubMed/NCBI

11 

Edge SB and Compton CC: The American Joint Committee on Cancer: The 7th edition of the AJCC Cancer Staging Manual and the Future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Greene FL and Sobin LH: A worldwide approach to the TNM staging system: Collaborative efforts of the AJCC and UICC. J Surg Oncol. 99:269–272. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Livak KG and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Olive V, Bennett MJ, Walker JC, Ma C, Jiang I, Cordon-Cardo C, Li QJ, Lowe SW, Hannon GJ and He L: miR-19 is a key oncogenic component of mir-17-92. Genes Dev. 23:2839–2849. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Yang D, Liu G and Wang K: miR-203 Acts as a tumor suppressor gene in osteosarcoma by regulating RAB22A. PLoS One. 10:e01322252015. View Article : Google Scholar : PubMed/NCBI

16 

Zhou J, Lu S, Yang S, Chen H, Shi H, Miao M and Jiao B: MicroRNA-127 post-transcriptionally downregulates Sept7 and suppresses cell growth in hepatocellular carcinoma cells. Cell Physiol Biochem. 33:1537–1546. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Chen F, Qi S, Zhang X, Wu J, Yang X and Wang R: miR-23a-3p suppresses cell proliferation in oral squamous cell carcinomas by targeting FGF2 and correlates with a better prognosis: miR-23a-3p inhibits OSCC growth by targeting FGF2. Pathol Res Pract. 215:660–667. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Ding F, Lai J, Gao Y, Wang G, Shang J, Zhang D and Zheng S: NEAT1/miR-23a-3p/KLF3: A novel regulatory axis in melanoma cancer progression. Cancer Cell Int. 19:2172019. View Article : Google Scholar : PubMed/NCBI

19 

Liu J, Fan L, Yu H, Zhang J, He Y, Feng D, Wang F, Li X, Liu Q, Li Y, et al: Endoplasmic reticulum stress causes liver cancer cells to release exosomal miR-23a-3p and Up-regulate programmed death ligand 1 expression in macrophages. Hepatology. 70:241–258. 2019.PubMed/NCBI

20 

Quan J, Pan X, Li Y, Hu Y, Tao L, Li Z, Zhao L, Wang J, Li H, Lai Y, et al: MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC. Biomed Pharmacother. 110:656–666. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Karmakar S, Kaushik G, Nimmakayala R, Rachagani S, Ponnusamy MP and Batra SK: MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention. Semin Cancer Biol. 54:63–71. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Vychytilova-Faltejskova P, Radova L, Sachlova M, Kosarova Z, Slaba K, Fabian P, Grolich T, Prochazka V, Kala Z, Svoboda M, et al: Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer. Carcinogenesis. 37:941–950. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Ostenfeld MS, Jensen SG, Jeppesen DK, Christensen LL, Thorsen SB, Stenvang J, Hvam ML, Thomsen A, Mouritzen P, Rasmussen MH, et al: miRNA profiling of circulating EpCAM(+) extracellular vesicles: Promising biomarkers of colorectal cancer. J Extracell Vesicles. 5:314882016. View Article : Google Scholar : PubMed/NCBI

24 

Jahid S, Sun J, Edwards RA, Dizon D, Panarelli NC, Milsom JW, Sikandar SS, Gumus ZH and Lipkin SM: miR-23a promotes the transition from indolent to invasive colorectal cancer. Cancer Discov. 2:540–553. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Zhu L, Jin L, Jiang R, Wang Q, Jiang J, Mao C and Chen D: Correlations between miRNAs and TGF-β1 in tumor microenvironment of esophageal squamous cell cancer. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 29:524–528. 2013.(In Chinese). PubMed/NCBI

26 

Ito S, Kamoto Y, Sakai A, Sasai K, Hayashi T, Toyooka S and Katayama H: Unique circulating microRNAs in relation to EGFR mutation status in Japanese smoker male with lung adenocarcinoma. Oncotarget. 8:114685–114697. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Honegger A, Schilling D, Bastian S, Sponagel J, Kuryshev V, Sultmann H, Scheffner M, Hoppe-Seyler K and Hoppe-Seyler F: Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells. PLoS Pathog. 11:e10047122015. View Article : Google Scholar : PubMed/NCBI

28 

Calatayud D, Dehlendorff C, Boisen MK, Hasselby JP, Schultz NA, Werner J, Immervoll H, Molven A, Hansen CP and Johansen JS: Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers. Biomark Res. 5:82017. View Article : Google Scholar : PubMed/NCBI

29 

Drabsch Y and ten Dijke P: TGF-β signalling and its role in cancer progression and metastasis. Cancer Metastasis Rev. 31:553–568. 2012. View Article : Google Scholar : PubMed/NCBI

30 

He H, Zhao X, Zhu Z, Du L, Chen E, Liu S, Li Q, Dong J, Yang J and Lei L: MicroRNA-3191 promotes migration and invasion by downregulating TGFBR2 in colorectal cancer. J Biochem Mol Toxicol. e22308:2019.

31 

Tarfiei GA, Shadboorestan A, Montazeri H, Rahmanian N, Tavosi G and Ghahremani MH: GDF15 induced apoptosis and cytotoxicity in A549 cells depends on TGFBR2 expression. Cell Biochem Funct. 37:320–330. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Wang Y, Tan X, Tang Y, Zhang C, Xu J, Zhou J, Cheng X, Hou N, Liu W, Yang G, et al: Dysregulated Tgfbr2/ERK-Smad4/SOX2 signaling promotes lung squamous cell carcinoma formation. Cancer Res. 79:4466–4479. 2019.PubMed/NCBI

33 

Shima K, Morikawa T, Yamauchi M, Kuchiba A, Imamura Y, Liao X, Meyerhardt JA, Fuchs CS and Ogino S: TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers. PLoS One. 6:e250622011. View Article : Google Scholar : PubMed/NCBI

34 

Zhou B, Guo W, Sun C, Zhang B and Zheng F: Linc00462 promotes pancreatic cancer invasiveness through the miR-665/TGFBR1-TGFBR2/SMAD2/3 pathway. Cell Death Dis. 9:7062018. View Article : Google Scholar : PubMed/NCBI

35 

Yang H, Zhang H, Zhong Y, Wang Q, Yang L, Kang H, Gao X, Yu H, Xie C, Zhou F and Zhou Y: Concomitant underexpression of TGFBR2 and overexpression of hTERT are associated with poor prognosis in cervical cancer. Sci Rep. 7:416702017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chao J, Jin L, Zhang X, Ding D, Wu S, Ma L, Zhu B, Shan S, Yun X, Gao P, Gao P, et al: Insight into the effects of microRNA‑23a‑3p on pancreatic cancer and its underlying molecular mechanism. Oncol Lett 19: 187-194, 2020.
APA
Chao, J., Jin, L., Zhang, X., Ding, D., Wu, S., Ma, L. ... Qin, X. (2020). Insight into the effects of microRNA‑23a‑3p on pancreatic cancer and its underlying molecular mechanism. Oncology Letters, 19, 187-194. https://doi.org/10.3892/ol.2019.11117
MLA
Chao, J., Jin, L., Zhang, X., Ding, D., Wu, S., Ma, L., Zhu, B., Shan, S., Yun, X., Gao, P., Li, J., Zhu, C., Qin, X."Insight into the effects of microRNA‑23a‑3p on pancreatic cancer and its underlying molecular mechanism". Oncology Letters 19.1 (2020): 187-194.
Chicago
Chao, J., Jin, L., Zhang, X., Ding, D., Wu, S., Ma, L., Zhu, B., Shan, S., Yun, X., Gao, P., Li, J., Zhu, C., Qin, X."Insight into the effects of microRNA‑23a‑3p on pancreatic cancer and its underlying molecular mechanism". Oncology Letters 19, no. 1 (2020): 187-194. https://doi.org/10.3892/ol.2019.11117
Copy and paste a formatted citation
x
Spandidos Publications style
Chao J, Jin L, Zhang X, Ding D, Wu S, Ma L, Zhu B, Shan S, Yun X, Gao P, Gao P, et al: Insight into the effects of microRNA‑23a‑3p on pancreatic cancer and its underlying molecular mechanism. Oncol Lett 19: 187-194, 2020.
APA
Chao, J., Jin, L., Zhang, X., Ding, D., Wu, S., Ma, L. ... Qin, X. (2020). Insight into the effects of microRNA‑23a‑3p on pancreatic cancer and its underlying molecular mechanism. Oncology Letters, 19, 187-194. https://doi.org/10.3892/ol.2019.11117
MLA
Chao, J., Jin, L., Zhang, X., Ding, D., Wu, S., Ma, L., Zhu, B., Shan, S., Yun, X., Gao, P., Li, J., Zhu, C., Qin, X."Insight into the effects of microRNA‑23a‑3p on pancreatic cancer and its underlying molecular mechanism". Oncology Letters 19.1 (2020): 187-194.
Chicago
Chao, J., Jin, L., Zhang, X., Ding, D., Wu, S., Ma, L., Zhu, B., Shan, S., Yun, X., Gao, P., Li, J., Zhu, C., Qin, X."Insight into the effects of microRNA‑23a‑3p on pancreatic cancer and its underlying molecular mechanism". Oncology Letters 19, no. 1 (2020): 187-194. https://doi.org/10.3892/ol.2019.11117
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team