|
1
|
Bray F, Ferlay J, Soerjomataram I, Siegel
RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN
estimates of incidence and mortality worldwide for 36 cancers in
185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
McGuigan A, Kelly P, Turkington RC, Jones
C, Coleman HG and McCain RS: Pancreatic cancer: A review of
clinical diagnosis, epidemiology, treatment and outcomes. World J
Gastroenterol. 24:4846–4861. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Puleo F, Maréchal R, Demetter P, Bali MA,
Calomme A, Closset J, Bachet JB, Deviere J and Van Laethem JL: New
challenges in perioperative management of pancreatic cancer. World
J Gastroenterol. 21:2281–2293. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Szatmári T, Mundt F, Kumar-Singh A, Möbus
L, Ötvös R, Hjerpe A and Dobra K: Molecular targets and signaling
pathways regulated by nuclear translocation of syndecan-1. BMC Cell
Biol. 18:342017. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Ibrahim SA, Gadalla R, El-Ghonaimy EA,
Samir O, Mohamed HT, Hassan H, Greve B, El-Shinawi M, Mohamed MM
and Götte M: Syndecan-1 is a novel molecular marker for triple
negative inflammatory breast cancer and modulates the cancer stem
cell phenotype via the IL-6/STAT3, Notch and EGFR signaling
pathways. Mol Cancer. 16:572017. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Jung O, Trapp-Stamborski V, Purushothaman
A, Jin H, Wang H, Sanderson RD and Rapraeger AC: Heparanase-induced
shedding of syndecan-1/CD138 in myeloma and endothelial cells
activates VEGFR2 and an invasive phenotype: Prevention by novel
synstatins. Oncogenesis. 5:e2022016. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Meirovitz A, Hermano E, Lerner I, Zcharia
E, Pisano C, Peretz T and Elkin M: Role of heparanase in
radiation-enhanced invasiveness of pancreatic carcinoma. Cancer
Res. 71:2772–2780. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Quiros RM, Rao G, Plate J, Harris JE,
Brunn GJ, Platt JL, Gattuso P, Prinz RA and Xu X: Elevated serum
heparanase-1 levels in patients with pancreatic carcinoma are
associated with poor survival. Cancer. 106:532–540. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Hegab AE, Ozaki M, Kameyama N, Gao J,
Kagawa S, Yasuda H, Soejima K, Yin Y, Guzy RD, Nakamura Y, et al:
Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its
cancer-associated fibroblasts. J Pathol. 249:193–205. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
La Venuta G, Zeitler M, Steringer JP,
Müller HM and Nickel W: The startling properties of fibroblast
growth factor 2: How to exit mammalian cells without a signal
peptide at hand. J Biol Chem. 290:27015–27020. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Masola V, Zaza G, Secchi MF, Gambaro G,
Lupo A and Onisto M: Heparanase is a key player in renal fibrosis
by regulating TGF-β expression and activity. Biochim Biophys Acta.
1843:2122–2128. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Yang Y, MacLeod V, Miao HQ, Theus A, Zhan
F, Shaughnessy JD Jr, Sawyer J, Li JP, Zcharia E, Vlodavsky I and
Sanderson RD: Heparanase enhances syndecan-1 shedding: A novel
mechanism for stimulation of tumor growth and metastasis. J Biol
Chem. 282:13326–13333. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Goicoechea SM, García-Mata R, Staub J,
Valdivia A, Sharek L, McCulloch CG, Hwang RF, Urrutia R, Yeh JJ,
Kim HJ and Otey CA: Palladin promotes invasion of pancreatic cancer
cells by enhancing invadopodia formation in cancer-associated
fibroblasts. Oncogene. 33:1265–1273. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Chin YR and Toker A: Akt2 regulates
expression of the actin-bundling protein Palladin. FEBS Lett.
584:4769–4774. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Bame KJ: Heparanases: Endoglycosidases
that degrade heparan sulfate proteoglycans. Glycobiology.
11:91R–98R. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Nasser NJ: Heparanase involvement in
physiology and disease. Cell Mol Life Sci. 65:1706–1715. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Purushothaman A, Uyama T, Kobayashi F,
Yamada S, Sugahara K, Rapraeger AC and Sanderson RD:
Heparanase-enhanced shedding of syndecan-1 by myeloma cells
promotes endothelial invasion and angiogenesis. Blood.
115:2449–2457. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Okawa T, Naomoto Y, Nobuhisa T, Takaoka M,
Motoki T, Shirakawa Y, Yamatsuji T, Inoue H, Ouchida M, Gunduz M,
et al: Heparanase is involved in angiogenesis in esophageal cancer
through induction of cyclooxygenase-2. Clin Cancer Res.
11:7995–8005. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Masola V, Zaza G, Onisto M, Lupo A and
Gambaro G: Impact of heparanase on renal fibrosis. J Transl Med.
13:1812015. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Gingis-Velitski S, Zetser A, Kaplan V,
Ben-Zaken O, Cohen E, Levy-Adam F, Bashenko Y, Flugelman MY,
Vlodavsky I and Ilan N: Heparanase uptake is mediated by cell
membrane heparan sulfate proteoglycans. J Biol Chem.
279:44084–44092. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Meirovitz A, Goldberg R, Binder A,
Rubinstein AM, Hermano E and Elkin M: Heparanase in inflammation
and inflammation-associated cancer. FEBS J. 280:2307–2319. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Sanderson RD, Elkin M, Rapraeger AC, Ilan
N and Vlodavsky I: Heparanase regulation of cancer, autophagy and
inflammation: New mechanisms and targets for therapy. FEBS J.
284:42–55. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Rugo HS, Delord JP, Im SA, Ott PA,
Piha-Paul SA, Bedard PL, Sachdev J, Tourneau CL, van Brummelen EMJ,
Varga A, et al: Safety and antitumor activity of pembrolizumab in
patients with estrogen receptor-positive/human epidermal growth
factor receptor 2-negative advanced breast cancer. Clin Cancer Res.
24:2804–2811. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Qu Y, Zhang H, Sun W, Han Y, Li S, Qu Y,
Ying G and Ba Y: MicroRNA-155 promotes gastric cancer growth and
invasion by negatively regulating transforming growth factor-β
receptor 2. Cancer Sci. 109:618–628. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Nandy D and Mukhopadhyay D: Growth factor
mediated signaling in pancreatic pathogenesis. Cancers (Basel).
3:841–871. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Khurana A, Liu P, Mellone P, Lorenzon L,
Vincenzi B, Datta K, Yang B, Linhardt RJ, Lingle W, Chien J, et al:
HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion
of breast cancer cells. Cancer Res. 71:2152–2161. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Li T, Meng XL and Yang WQ: Long noncoding
RNA PVT1 acts as a ‘Sponge’ to inhibit microRNA-152 in gastric
cancer cells. Dig Dis Sci. 62:3021–3028. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Coleman SJ, Chioni AM, Ghallab M, Anderson
RK, Lemoine NR, Kocher HM and Grose RP: Nuclear translocation of
FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic
cancer cell invasion. EMBO Mol Med. 6:467–481. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Kleeff J, Friess H, Buechler M, Kothari N,
Datta S, Fan H and Korc M: Adenovirus mediated transfer of a
truncated fibroblast growth factor (FGF) typ I receptor blocks FGF2
signaling in pancreatic cancer cells. Gastroenterology.
124:A1042003. View Article : Google Scholar
|
|
31
|
Li RW, Freeman C, Yu D, Hindmarsh EJ,
Tymms KE, Parish CR and Smith PN: Dramatic regulation of heparanase
activity and angiogenesis gene expression in synovium from patients
with rheumatoid arthritis. Arthritis Rheum. 58:1590–1600. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Kato M, Wang H, Kainulainen V, Fitzgerald
ML, Ledbetter S, Ornitz DM and Bernfield M: Physiological
degradation converts the soluble syndecan-1 ectodomain from an
inhibitor to a potent activator of FGF-2. Nat Med. 4:691–697. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Dailey L, Ambrosetti D, Mansukhani A and
Basilico C: Mechanisms underlying differential responses to FGF
signaling. Cytokine Growth Factor Rev. 16:233–247. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Katoh M and Katoh M: Cross-talk of WNT and
FGF signaling pathways at GSK3beta to regulate beta-catenin and
SNAIL signaling cascades. Cancer Biol Ther. 5:1059–1064. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Boukhelifa M, Hwang SJ, Valtschanoff JG,
Meeker RB, Rustioni A and Otey CA: A critical role for Palladin in
astrocyte morphology and response to injury. Mol Cell Neurosci.
23:661–668. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Najm P and El-Sibai M: Palladin regulation
of the actin structures needed for cancer invasion. Cell Adh Migr.
8:29–35. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Goicoechea SM, Bednarski B, García-Mata R,
Prentice-Dunn H, Kim HJ and Otey CA: Palladin contributes to
invasive motility in human breast cancer cells. Oncogene.
28:587–598. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Yilmaz M and Christofori G: EMT, the
cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev.
28:15–33. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Brabletz T, Kalluri R, Nieto MA and
Weinberg RA: EMT in cancer. Nat Rev Cancer. 18:128–134. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Shibue T and Weinberg RA: EMT, CSCs, and
drug resistance: The mechanistic link and clinical implications.
Nat Rev Clin Oncol. 14:611–629. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Lamouille S, Xu J and Derynck R: Molecular
mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell
Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Thompson EW, Newgreen DF and Tarin D:
Carcinoma invasion and metastasis: A role for
epithelial-mesenchymal transition? Cancer Res. 65:5991–5995. 2005.
View Article : Google Scholar : PubMed/NCBI
|
