Open Access

A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer

  • Authors:
    • Xuan‑Mei Piao
    • Pildu Jeong
    • Chunri Yan
    • Ye‑Hwan Kim
    • Young Joon Byun
    • Yanjie Xu
    • Ho Won Kang
    • Sung Phil Seo
    • Won Tae Kim
    • Jong‑Young Lee
    • Isaac Y. Kim
    • Sung‑Kwon Moon
    • Yung Hyun Choi
    • Eun‑Jong Cha
    • Seok Joong Yun
    • Wun‑Jae Kim
  • View Affiliations

  • Published online on: November 19, 2019     https://doi.org/10.3892/ol.2019.11123
  • Pages: 476-486
  • Copyright: © Piao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Screening for genes or markers relevant to bladder cancer (BC) tumorigenesis and progression is of vital clinical significance. The present study used reverse‑transcription quantitative PCR reaction assays to examine the expression of mRNA encoding Rho GTPase‑activating protein 9 (ARHGAP9) in BC tissue samples and to determine whether ARHGAP9 is an independent prognostic biomarker for non‑muscle invasive BC (NMIBC) and muscle invasive BC (MIBC). The results revealed that the downregulation of ARHGAP9 expression in the tissue of patients with NMIBC or MIBC was significantly associated with a poor prognosis. In patients with NMIBC, a high expression of ARHGAP9 was significantly associated with prolonged recurrence‑free survival, whereas in MIBC patients, it was significantly associated with an increased progression‑free and cancer‑specific survival. The risk of cancer‑specific death was 2.923 times higher (95% confidence interval, 1.192‑7.163) when ARHGAP9 levels were decreased. In conclusion, lower expressions of ARHGAP9 correlated with BC prognosis, indicating that it may be a useful marker for guiding treatment application.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Piao XM, Jeong P, Yan C, Kim YH, Byun YJ, Xu Y, Kang HW, Seo SP, Kim WT, Lee JY, Lee JY, et al: A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer. Oncol Lett 19: 476-486, 2020
APA
Piao, X., Jeong, P., Yan, C., Kim, Y., Byun, Y.J., Xu, Y. ... Kim, W. (2020). A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer. Oncology Letters, 19, 476-486. https://doi.org/10.3892/ol.2019.11123
MLA
Piao, X., Jeong, P., Yan, C., Kim, Y., Byun, Y. J., Xu, Y., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Kim, I. Y., Moon, S., Choi, Y. H., Cha, E., Yun, S. J., Kim, W."A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer". Oncology Letters 19.1 (2020): 476-486.
Chicago
Piao, X., Jeong, P., Yan, C., Kim, Y., Byun, Y. J., Xu, Y., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Kim, I. Y., Moon, S., Choi, Y. H., Cha, E., Yun, S. J., Kim, W."A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer". Oncology Letters 19, no. 1 (2020): 476-486. https://doi.org/10.3892/ol.2019.11123