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A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer

  • Authors:
    • Xuan‑Mei Piao
    • Pildu Jeong
    • Chunri Yan
    • Ye‑Hwan Kim
    • Young Joon Byun
    • Yanjie Xu
    • Ho Won Kang
    • Sung Phil Seo
    • Won Tae Kim
    • Jong‑Young Lee
    • Isaac Y. Kim
    • Sung‑Kwon Moon
    • Yung Hyun Choi
    • Eun‑Jong Cha
    • Seok Joong Yun
    • Wun‑Jae Kim
  • View Affiliations / Copyright

    Affiliations: Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Chungcheongbuk-do 28644, Republic of Korea, Department of Preventative Medicine, School of Medicine, Yanbian University, Yanji, Jilin 133000, P.R. China, Department of Surgery, College of Medicine, Chungbuk National University, Cheongju, Chungcheongbuk-do 28644, Republic of Korea, Department of Business Data Convergence, Chungbuk National University, Cheongju, Chungcheongbuk-do 28644, Republic of Korea, Section of Urologic Oncology and Dean and Betty Gallo Prostate Cancer Center, The Cancer Institute of New Jersey and Robert Wood Johnson Medical School, New Brunswick, NJ 732‑235, USA, Department of Food Science and Technology, Chung‑Ang University, Ansung, Gyeonggi-do 456‑756, Republic of Korea, Department of Biochemistry, College of Oriental Medicine, Dong‑Eui University, Busan 614‑052, Republic of Korea, Department of Biomedical Engineering, College of Medicine, Chungbuk National University, Cheongju, Chungcheongbuk-do 28644, Republic of Korea
    Copyright: © Piao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 476-486
    |
    Published online on: November 19, 2019
       https://doi.org/10.3892/ol.2019.11123
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Abstract

Screening for genes or markers relevant to bladder cancer (BC) tumorigenesis and progression is of vital clinical significance. The present study used reverse‑transcription quantitative PCR reaction assays to examine the expression of mRNA encoding Rho GTPase‑activating protein 9 (ARHGAP9) in BC tissue samples and to determine whether ARHGAP9 is an independent prognostic biomarker for non‑muscle invasive BC (NMIBC) and muscle invasive BC (MIBC). The results revealed that the downregulation of ARHGAP9 expression in the tissue of patients with NMIBC or MIBC was significantly associated with a poor prognosis. In patients with NMIBC, a high expression of ARHGAP9 was significantly associated with prolonged recurrence‑free survival, whereas in MIBC patients, it was significantly associated with an increased progression‑free and cancer‑specific survival. The risk of cancer‑specific death was 2.923 times higher (95% confidence interval, 1.192‑7.163) when ARHGAP9 levels were decreased. In conclusion, lower expressions of ARHGAP9 correlated with BC prognosis, indicating that it may be a useful marker for guiding treatment application.
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Copy and paste a formatted citation
Spandidos Publications style
Piao XM, Jeong P, Yan C, Kim YH, Byun YJ, Xu Y, Kang HW, Seo SP, Kim WT, Lee JY, Lee JY, et al: A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer. Oncol Lett 19: 476-486, 2020.
APA
Piao, X., Jeong, P., Yan, C., Kim, Y., Byun, Y.J., Xu, Y. ... Kim, W. (2020). A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer. Oncology Letters, 19, 476-486. https://doi.org/10.3892/ol.2019.11123
MLA
Piao, X., Jeong, P., Yan, C., Kim, Y., Byun, Y. J., Xu, Y., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Kim, I. Y., Moon, S., Choi, Y. H., Cha, E., Yun, S. J., Kim, W."A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer". Oncology Letters 19.1 (2020): 476-486.
Chicago
Piao, X., Jeong, P., Yan, C., Kim, Y., Byun, Y. J., Xu, Y., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Kim, I. Y., Moon, S., Choi, Y. H., Cha, E., Yun, S. J., Kim, W."A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer". Oncology Letters 19, no. 1 (2020): 476-486. https://doi.org/10.3892/ol.2019.11123
Copy and paste a formatted citation
x
Spandidos Publications style
Piao XM, Jeong P, Yan C, Kim YH, Byun YJ, Xu Y, Kang HW, Seo SP, Kim WT, Lee JY, Lee JY, et al: A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer. Oncol Lett 19: 476-486, 2020.
APA
Piao, X., Jeong, P., Yan, C., Kim, Y., Byun, Y.J., Xu, Y. ... Kim, W. (2020). A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer. Oncology Letters, 19, 476-486. https://doi.org/10.3892/ol.2019.11123
MLA
Piao, X., Jeong, P., Yan, C., Kim, Y., Byun, Y. J., Xu, Y., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Kim, I. Y., Moon, S., Choi, Y. H., Cha, E., Yun, S. J., Kim, W."A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer". Oncology Letters 19.1 (2020): 476-486.
Chicago
Piao, X., Jeong, P., Yan, C., Kim, Y., Byun, Y. J., Xu, Y., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J., Kim, I. Y., Moon, S., Choi, Y. H., Cha, E., Yun, S. J., Kim, W."A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer". Oncology Letters 19, no. 1 (2020): 476-486. https://doi.org/10.3892/ol.2019.11123
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