Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

BMP‑9 is a novel marker for colorectal tumorigenesis undergoing the normal mucosa‑adenoma‑adenocarcinoma sequence and is associated with colorectal cancer prognosis

  • Authors:
    • Yinjie Fan
    • Lingxiang Guo
    • Huachuan Zheng
    • Chunyong Ji
    • Wenbin Wang
    • Hongzhi Sun
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Affiliated Zhengzhou Central Hospital of Zhengzhou University, Zhengzhou, Henan 450007, P.R. China, Department of Experimental Oncology and Animal Center, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China
    Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 271-282
    |
    Published online on: November 19, 2019
       https://doi.org/10.3892/ol.2019.11125
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Depending on the type of cancer, bone morphogenetic protein‑9 (BMP‑9) can promote or inhibit tumorigenesis; however, the function of BMP‑9 in colorectal cancer remains unclear. The aim of the present study was to evaluate the clinicopathological importance of BMP‑9 expression in the tumorigenesis of normal colorectal epithelial tissue, and subsequent transformation into adenoma and carcinoma. In addition, the present study aimed to determine the prognostic value of BMP‑9 on the survival of patients with colorectal cancer (CRC). A total of 65 patients with pathologically confirmed colorectal adenocarcinoma and a history of adenoma were enrolled. BMP‑9 and Ki‑67 expression was assessed retrospectively using paraffin‑embedded samples of normal colorectal mucosa, colorectal adenoma and CRC obtained from each patient. The prognostic value of BMP‑9 expression was analyzed in a group comprising 48 patients with CRC and a mean follow‑up duration of 39.1 months. Bioinformatics analyses were performed in order to validate the results of the present study using published CRC datasets. The results from the present study suggested that the expression of BMP‑9 gradually increased during the transition from normal mucosa to adenoma and subsequent adenocarcinoma (P<0.05); however, no significant association between the expression levels of BMP‑9 and the clinicopathological parameters of patients was reported. Kaplan‑Meier analysis revealed that patients with high expression levels of BMP‑9 exhibited shorter overall survival rate than those with low levels of expression (54.7 vs. 41.3 months; log‑rank test, P<0.05). Furthermore, regardless of tumor location and the presence of blood vessel tumor emboli, the univariate and multivariate analyses indicated that BMP‑9 expression may be an independent prognostic factor for the overall survival rate of patients with CRC. The results of the present study suggested that BMP‑9 may serve an oncogenic role and possess prognostic value in CRC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A and Jemal A: Colorectal cancer statistics, 2017. CA Cancer J Clin. 67:177–193. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Fearon ER and Vogelstein B: A genetic model for colorectal tumorigenesis. Cell. 61:759–767. 1990. View Article : Google Scholar : PubMed/NCBI

4 

Vincent MD: Cancer: Beyond speciation. Adv Cancer Res. 112:283–350. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Terzić J, Grivennikov S, Karin E and Karin M: Inflammation and colon cancer. Gastroenterology. 138:2101–2114. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Yokoyama Y, Watanabe T, Tamura Y, Hashizume Y, Miyazono K and Ehata S: Autocrine BMP-4 signaling is a therapeutic target in colorectal cancer. Cancer Res. 77:4026–4038. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Miyazono K, Kamiya Y and Morikawa M: Bone morphogenetic protein receptors and signal transduction. J Biochem. 147:35–51. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Zhang Y, Chen X, Qiao M, Zhang BQ, Wang N, Zhang Z, Liao Z, Zeng L, Deng Y, Deng F, et al: Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells. Oncol Rep. 32:1013–1020. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Chen D, Zhao M, Harris SE and Mi Z: Signal transduction and biological functions of bone morphogenetic proteins. Front Biosci. 9:349–358. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Celeste AJ: Bone morphogenetic protein-9, a new member of the TGF-β superfamily. J Bone Miner Res. 1(9): S1361994.

11 

Wagner DO, Sieber C, Bhushan R, Börgermann JH, Graf D and Knaus P: BMPs: From bone to body morphogenetic proteins. Sci Signal. 3:mr12010.PubMed/NCBI

12 

Plouhinec JL, Zakin L and De Robertis EM: Systems control of BMP morphogen flow in vertebrate embryos. Curr Opin Genet Dev. 21:696–703. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Reddi AH and Reddi A: Bone morphogenetic proteins (BMPs): From morphogens to metabologens. Cytokine Growth Factor Rev. 20:341–342. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Ploemacher RE, Engels LJ, Mayen AE, Thies S and Neben S: Bone morphogenetic protein 9 is a potent synergistic factor for murine hemopoietic progenitor cell generation and colony formation in serum-free cultures. Leukemia. 13:428–437. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Helm GA, Alden TD, Beres EJ, Hudson SB, Das S, Engh JA, Pittman DD, Kerns KM and Kallmes DF: Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent. J Neurosurg. 92 (Suppl):S191–S196. 2000.

16 

Lopez-Coviella I, Berse B, Krauss R, Thies RS and Blusztajn JK: Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9. Science. 28:313–316. 2000. View Article : Google Scholar

17 

Chen C, Grzegorzewski KJ, Barash S, Zhao Q, Schneider H, Wang Q, Singh M, Pukac L, Bell AC, Duan R, et al: An integrated functionalgenomics screening program reveals a role for BMP-9 in glucose homeostasis. Nat Biotechnol. 21:294–301. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Truksa J, Peng HF, Lee P and Beutler E: Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci USA. 103:10289–10293. 2006. View Article : Google Scholar : PubMed/NCBI

19 

David L, Mallet C, Mazerbourg S, Feige JJ and Bailly S: Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood. 109:1953–1961. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Na KY, Kim HS, Lee SK, Jung WW, Sung JY, Kim YW and Park YK: Papillary thyroid carcinoma with bone formation. Pathol Res Pract. 209:14–18. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Herrera B, van Dinther M, Ten Dijke P and Inman GJ: Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation. Cancer Res. 69:9254–9262. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Herrera B, García-Álvaro M, Cruz S, Walsh P, Fernández M, Roncero C, Fabregat I, Sánchez A and Inman GJ: BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells. PLoS One. 8:e695352013. View Article : Google Scholar : PubMed/NCBI

23 

Li Q, Gu X, Weng H, Ghafoory S, Liu Y, Feng T, Dzieran J, Li L, Ilkavets I and Kruithof-de Julio M: Bone morphogenetic protein-9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells. Cancer Sci. 104:398–408. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Ye L, Kynaston H and Jiang WG: Bone morphogenetic protein-9 induces apoptosis in prostate cancer cells, the role of prostate apoptosis response-4. Mol Cancer Res. 6:1594–1606. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Olsen OE, Wader KF, Misund K, Våtsveen TK, Rø TB, Mylin AK, Turesson I, Størdal BF, Moen SH, Standal T, et al: Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J. 4:e1962014. View Article : Google Scholar : PubMed/NCBI

26 

Wan S, Liu Y, Weng Y, Wang W, Ren W, Fei C, Chen Y, Zhang Z, Wang T, Wang J, et al: BMP9 regulates cross-talk between breast cancer cells and bone marrow-derived mesenchymal stem cells. Cell Oncol (Dordr). 37:363–375. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Ren W, Liu Y, Wan S, Fei C, Wang W, Chen Y, Zhang Z, Wang T, Wang J, Zhou L, et al: BMP9 inhibits proliferation and metastasis of HER2-positive SK-BR-3 breast cancer cells through ERK1/2 and PI3K/AKT pathways. PLoS One. 9:e968162014. View Article : Google Scholar : PubMed/NCBI

28 

Ren W, Sun X, Wang K, Feng H, Liu Y, Fei C, Wan S, Wang W, Luo J, Shi Q, et al: BMP9 inhibits the bone metastasis of breast cancer cells by downregulating CCN2 (connective tissue growth factor, CTGF) expression. Mol Biol Rep. 41:1373–1383. 2014. View Article : Google Scholar : PubMed/NCBI

29 

America Joint Committee on Cancer, . The 7th edition of the AJCC cancer staging manual. 7th. New York: Springer; 2010

30 

Edge SB and Compton CC: The American joint committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Sarma DP: Dukes' classification of rectal cancer. South Med J. 81:407–408. 1988. View Article : Google Scholar : PubMed/NCBI

32 

Kurashina K, Yamashita Y, Ueno T, Koinuma K, Ohashi J, Horie H, Miyakura Y, Hamada T, Haruta H, Hatanaka H, et al: Chromosome copy number analysis in screening for prognosis- related genomic regions in colorectal carcinoma. Cancer Sci. 99:1835–1840. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Gaedcke J, Grade M, Jung K, Camps J, Jo P, Emons G, Gehoff A, Sax U, Schirmer M, Becker H, et al: Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas. Genes Chromosomes Cancer. 49:1024–1034. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Muto T, Bussey HJ and Morson BC: The evolution of cancer of the colon and rectum. Cancer. 36:2251–2270. 1975. View Article : Google Scholar : PubMed/NCBI

35 

Kinzler KW and Vogelstein B: Lessons from hereditary colorectal cancer. Cell. 87:159–170. 1996. View Article : Google Scholar : PubMed/NCBI

36 

Herrera B, Dooley S and Breitkopf-Heinlein K: Potential roles of bone morphogenetic protein (BMP)-9 in human liver diseases. Int J Mol Sci. 15:5199–5220. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Astrologo L, Zoni E, Karkampouna S, Gray PC, Klima I, Grosjean J, Goumans MJ, Hawinkels LJAC, van der Pluijm G, Spahn M, et al: ALK1Fc Suppresses the human prostate cancer growth in in vitro and in vivo preclinical models. Front Cell Dev Biol. 5:1042017. View Article : Google Scholar : PubMed/NCBI

38 

Lv Z, Yang D, Li J, Hu M, Luo M, Zhan X, Song P, Liu C, Bai H, Li B, et al: Bone morphogenetic protein 9 overexpression reduces osteosarcoma cell migration and invasion. Mol Cells. 36:119–126. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Hardwick JC, Kodach LL, Offerhaus GJ and van den Brink GR: Bone morphogenetic protein signalling in colorectal cancer. Nat Rev Cancer. 8:806–812. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Allaire JM, Roy SA, Ouellet C, Lemieux É, Jones C, Paquet M, Boudreau F and Perreault N: Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation. Int J Cancer. 138:2700–2712. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Voorneveld PW, Kodach LL, Jacobs RJ, van Noesel CJ, Peppelenbosch MP, Korkmaz KS, Molendijk I, Dekker E, Morreau H, van Pelt GW, et al: The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC. Br J Cancer. 112:122–130. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Howe JR, Bair JL, Sayed MG, Anderson ME, Mitros FA, Petersen GM, Velculescu VE, Traverso G and Vogelstein B: Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet. 28:184–187. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Davis H, Raja E, Miyazono K, Tsubakihara Y and Moustakas A: Mechanisms of action of bone morphogenetic proteins in cancer. Cytokine Growth Factor Rev. 27:81–92. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Loh K, Chia JA, Greco S, Cozzi SJ, Buttenshaw RL, Bond CE, Simms LA, Pike T, Young JP, Jass JR, et al: Bone morphogenetic protein 3 inactivation is an early and frequent event in colorectal cancer development. Genes Chromosomes Cancer. 47:449–460. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Yuan SX, Wang DX, Wu QX, Ren CM, Li Y, Chen QZ, Zeng YH, Shao Y, Yang JQ, Bai Y, et al: BMP9/p38 MAPK is essential for the antiproliferative effect of resveratrol on human colon cancer. Oncol Rep. 35:939–947. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Lorente-Trigos A, Varnat F, Melotti A, Ruiz I and Altaba A: BMP signaling promotes the growth of primary human colon carcinomas in vivo. J Mol Cell Biol. 2:318–332. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Sanjuan X, Fernández PL, Castells A, Castronovo V, van den Brule F, Liu FT, Cardesa A and Campo E: Differential expression of galectin 3 and galectin 1 in colorectal cancer progression. Gastroenterology. 113:1906–1915. 1997. View Article : Google Scholar : PubMed/NCBI

48 

Miyata Y, Watanabe S, Sagara Y, Mitsunari K, Matsuo T, Ohba K and Sakai H: High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer. PLoS One. 8:e590952013. View Article : Google Scholar : PubMed/NCBI

49 

Steinke-Lange V and Holinski-Feder E: Genetic screening and personalized prevention in colorectal cancer. Visc Med. 35:226–230. 2019. View Article : Google Scholar : PubMed/NCBI

50 

De Roock W, De Vriendt V, Normanno N, Ciardiello F and Tejpar S: KRAS, BRAF, PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol. 12:594–603. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Yoshimatsu Y, Lee YG, Akatsu Y, Taguchi L, Suzuki HI, Cunha SI, Maruyama K, Suzuki Y, Yamazaki T, Katsura A, et al: Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression. Proc Natl Acad Sci USA. 110:18940–18945. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Cunha SI and Pietras K: ALK1 as an emerging target for antiangiogenic therapy of cancer. Blood. 117:6999–7006. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fan Y, Guo L, Zheng H, Ji C, Wang W and Sun H: BMP‑9 is a novel marker for colorectal tumorigenesis undergoing the normal mucosa‑adenoma‑adenocarcinoma sequence and is associated with colorectal cancer prognosis. Oncol Lett 19: 271-282, 2020.
APA
Fan, Y., Guo, L., Zheng, H., Ji, C., Wang, W., & Sun, H. (2020). BMP‑9 is a novel marker for colorectal tumorigenesis undergoing the normal mucosa‑adenoma‑adenocarcinoma sequence and is associated with colorectal cancer prognosis. Oncology Letters, 19, 271-282. https://doi.org/10.3892/ol.2019.11125
MLA
Fan, Y., Guo, L., Zheng, H., Ji, C., Wang, W., Sun, H."BMP‑9 is a novel marker for colorectal tumorigenesis undergoing the normal mucosa‑adenoma‑adenocarcinoma sequence and is associated with colorectal cancer prognosis". Oncology Letters 19.1 (2020): 271-282.
Chicago
Fan, Y., Guo, L., Zheng, H., Ji, C., Wang, W., Sun, H."BMP‑9 is a novel marker for colorectal tumorigenesis undergoing the normal mucosa‑adenoma‑adenocarcinoma sequence and is associated with colorectal cancer prognosis". Oncology Letters 19, no. 1 (2020): 271-282. https://doi.org/10.3892/ol.2019.11125
Copy and paste a formatted citation
x
Spandidos Publications style
Fan Y, Guo L, Zheng H, Ji C, Wang W and Sun H: BMP‑9 is a novel marker for colorectal tumorigenesis undergoing the normal mucosa‑adenoma‑adenocarcinoma sequence and is associated with colorectal cancer prognosis. Oncol Lett 19: 271-282, 2020.
APA
Fan, Y., Guo, L., Zheng, H., Ji, C., Wang, W., & Sun, H. (2020). BMP‑9 is a novel marker for colorectal tumorigenesis undergoing the normal mucosa‑adenoma‑adenocarcinoma sequence and is associated with colorectal cancer prognosis. Oncology Letters, 19, 271-282. https://doi.org/10.3892/ol.2019.11125
MLA
Fan, Y., Guo, L., Zheng, H., Ji, C., Wang, W., Sun, H."BMP‑9 is a novel marker for colorectal tumorigenesis undergoing the normal mucosa‑adenoma‑adenocarcinoma sequence and is associated with colorectal cancer prognosis". Oncology Letters 19.1 (2020): 271-282.
Chicago
Fan, Y., Guo, L., Zheng, H., Ji, C., Wang, W., Sun, H."BMP‑9 is a novel marker for colorectal tumorigenesis undergoing the normal mucosa‑adenoma‑adenocarcinoma sequence and is associated with colorectal cancer prognosis". Oncology Letters 19, no. 1 (2020): 271-282. https://doi.org/10.3892/ol.2019.11125
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team