Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

MicroRNA‑431 serves as a tumor inhibitor in breast cancer through targeting FGF9

  • Authors:
    • Wei Wang
    • Yan Dong
    • Xiaoyan Li
    • Yingying Pan
    • Jiexin Du
    • Daotong Liu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Zhangqiu Maternity and Child Care Hospital, Jinan, Shandong 250200, P.R. China, Breast Clinic Center, Qingdao Central Hospital, Qingdao, Shandong 266042, P.R. China, Department of Clinical Nutrition, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Renal Rheumatism Intervention Department, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Neurology, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Breast and Thyroid Surgery, Jining No. 1 People's Hospital, Jining, Shandong 272000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1001-1007
    |
    Published online on: November 20, 2019
       https://doi.org/10.3892/ol.2019.11126
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Breast cancer has become an important public health problem. Moreover, the functions of microRNA‑431 (miR‑431) have been detected in human cancers other than breast cancer. Hence, we investigated the role of miR‑431 in progression of breast cancer. RT‑qPCR and Western blot analysis were performed to assess expression of miR‑431 and genes. The regulatory mechanism of miR‑431 was investigated using MTT, Transwell and luciferase reporter assay. Decreased miR‑431 expression was identified in breast cancer, which was related to aggressive behavior. Furthermore, miR‑431 restrained cell proliferation, metastasis and EMT in breast cancer. miR‑431 induced apoptosis through enhancing Bax expression. In addition, miR‑431 was found to directly target FGF9. Moreover, upregulation of FGF9 impaired the anti‑tumor effect of miR‑431 in breast cancer. miR‑431 restrained cell viability and metastasis in breast cancer through targeting FGF9, indicating that miR‑431 serves as a tumor inhibitor in breast cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Center MM, DeSantis C and Ward EM: Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 19:1893–1907. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Strom C: Breast cancer: Diagnostic service shares BRCA data. Nature. 522:342015. View Article : Google Scholar : PubMed/NCBI

4 

Zhou M, Zhong L, Xu W, Sun Y, Zhang Z, Zhao H, Yang L and Sun J: Discovery of potential prognostic long non-coding RNA biomarkers for predicting the risk of tumor recurrence of breast cancer patients. Sci Rep. 6:310382016. View Article : Google Scholar : PubMed/NCBI

5 

Yin Y, Cai J, Meng F, Sui C and Jiang Y: miR-144 suppresses proliferation, invasion, and migration of breast cancer cells through inhibiting CEP55. Cancer Biol Ther. 19:306–315. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Hwang MS, Yu N, Stinson SY, Yue P, Newman RJ, Allan BB and Dornan D: miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer. PLoS One. 8:e665022013. View Article : Google Scholar : PubMed/NCBI

7 

Yang X and Meng T: MicroRNA-431 affects trophoblast migration and invasion by targeting ZEB1 in preeclampsia. Gene. 683:225–232. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Kwok GTY, Zhao JT, Glover AR, Gill AJ, Clifton-Bligh R, Robinson BG, Ip JCY and Sidhu SB: microRNA-431 as a chemosensitizer and potentiator of drug activity in adrenocortical carcinoma. Oncologist. 24:e241–e250. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Lee KP, Shin YJ, Panda AC, Abdelmohsen K, Kim JY, Lee SM, Bahn YJ, Choi JY, Kwon ES, Baek SJ, et al: miR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4. Genes Dev. 29:1605–1617. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Liu Y, Li L, Liu Z, Yuan Q and Lu X: Downregulation of miR-431 expression associated with lymph node metastasis and promotes cell invasion in papillary thyroid carcinoma. Cancer Biomark. 22:727–732. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Yang J, Zhu H, Jin Y and Song Y: miR-431 inhibits cell proliferation and induces cell apoptosis by targeting CDK14 in pancreatic cancer. Eur Rev Med Pharmacol Sci. 22:4493–4499. 2018.PubMed/NCBI

12 

Su N, Jin M and Chen L: Role of FGF/FGFR signaling in skeletal development and homeostasis: Learning from mouse models. Bone Res. 2:140032014. View Article : Google Scholar : PubMed/NCBI

13 

Ohgino K, Soejima K, Yasuda H, Hayashi Y, Hamamoto J, Naoki K, Arai D, Ishioka K, Sato T, Terai H, et al: Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer. Lung Cancer. 83:90–96. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Wang S, Lin H, Zhao T, Huang S, Fernig DG, Xu N, Wu F, Zhou M, Jiang C and Tian H: Expression and purification of an FGF9 fusion protein in E. coli, and the effects of the FGF9 subfamily on human hepatocellular carcinoma cell proliferation and migration. Appl Microbiol Biotechnol. 101:7823–7835. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Li K, Pan J, Wang J, Liu F and Wang L: miR-665 regulates VSMCs proliferation via targeting FGF9 and MEF2D and modulating activities of Wnt/β-catenin signaling. Am J Transl Res. 9:4402–4414. 2017.PubMed/NCBI

16 

Yang H, Fang F, Chang R and Yang L: MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma. Hepatology. 58:205–217. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Li W, Yi J, Zheng X, Liu S, Fu W, Ren L, Li L, Hoon DSB, Wang J and Du G: miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway. Clin Epigenetics. 10:642018. View Article : Google Scholar : PubMed/NCBI

18 

Zhang J, He Y, Yu Y, Chen X, Cui G, Wang W, Zhang X, Luo Y, Li J, Ren F, et al: Upregulation of miR-374a promotes tumor metastasis and progression by downregulating LACTB and predicts unfavorable prognosis in breast cancer. Cancer Med. 7:3351–3362. 2018. View Article : Google Scholar

19 

Jiang Q, Cheng L, Ma D and Zhao Y: FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer. Biosci Rep. 39:392019. View Article : Google Scholar

20 

Li MF, Li YH, He YH, Wang Q, Zhang Y, Li XF, Meng XM, Huang C and Li J: Emerging roles of hsa_circ_0005075 targeting miR-431 in the progress of HCC. Biomed Pharmacother. 99:848–858. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Pan L, Ren F, Rong M, Dang Y, Luo Y, Luo D and Chen G: Correlation between down-expression of miR-431 and clinicopathological significance in HCC tissues. Clin Transl Oncol. 17:557–563. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Sun K, Zeng T, Huang D, Liu Z, Huang S, Liu J and Qu Z: MicroRNA-431 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the ZEB1-mediated epithelial-mensenchymal transition. FEBS Open Bio. 5:900–907. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Xu CM, Chen LX, Gao F, Zhu MF, Dai Y, Xu Y and Qian WX: miR-431 suppresses proliferation and metastasis of lung cancer via down-regulating DDX5. Eur Rev Med Pharmacol Sci. 23:699–707. 2019.PubMed/NCBI

24 

Wu YZ, Chan KYY, Leung KT, Lam HS, Tam YH, Lee KH, Li K and Ng PC: Dysregulation of miR-431 and target gene FOXA1 in intestinal tissues of infants with necrotizing enterocolitis. FASEB J. 33:5143–5152. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Kong Q, Han J, Deng H, Wu F, Guo S and Ye Z: miR-431-5p alters the epithelial-to-mesenchymal transition markers by targeting UROC28 in hepatoma cells. OncoTargets Ther. 11:6489–6503. 2018. View Article : Google Scholar

26 

Yu B, Qian T, Wang Y, Zhou S, Ding G, Ding F and Gu X: miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage following sciatic nerve injury. Nucleic Acids Res. 40:10356–10365. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Rao C, Miao X, Zhao G, Zhang C, Shen H, Dong C and Yang M: miR-219a-5p enhances cisplatin sensitivity of human non-small cell lung cancer by targeting FGF9. Biomed Pharmacother. 114:1086622019. View Article : Google Scholar : PubMed/NCBI

28 

Deng M, Tang HL, Lu XH, Liu MY, Lu XM, Gu YX, Liu JF and He ZM: miR-26a suppresses tumor growth and metastasis by targeting FGF9 in gastric cancer. PLoS One. 8:e726622013. View Article : Google Scholar : PubMed/NCBI

29 

Liang H, Luo R, Chen X, Zhao Y and Tan A: miR-187 inhibits the growth of cervical cancer cells by targeting FGF9. Oncol Rep. 38:1977–1984. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Wang R, Sun Y, Yu W, Yan Y, Qiao M, Jiang R, Guan W and Wang L: Downregulation of miRNA-214 in cancer-associated fibroblasts contributes to migration and invasion of gastric cancer cells through targeting FGF9 and inducing EMT. J Exp Clin Cancer Res. 38:202019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang W, Dong Y, Li X, Pan Y, Du J and Liu D: MicroRNA‑431 serves as a tumor inhibitor in breast cancer through targeting FGF9. Oncol Lett 19: 1001-1007, 2020.
APA
Wang, W., Dong, Y., Li, X., Pan, Y., Du, J., & Liu, D. (2020). MicroRNA‑431 serves as a tumor inhibitor in breast cancer through targeting FGF9. Oncology Letters, 19, 1001-1007. https://doi.org/10.3892/ol.2019.11126
MLA
Wang, W., Dong, Y., Li, X., Pan, Y., Du, J., Liu, D."MicroRNA‑431 serves as a tumor inhibitor in breast cancer through targeting FGF9". Oncology Letters 19.1 (2020): 1001-1007.
Chicago
Wang, W., Dong, Y., Li, X., Pan, Y., Du, J., Liu, D."MicroRNA‑431 serves as a tumor inhibitor in breast cancer through targeting FGF9". Oncology Letters 19, no. 1 (2020): 1001-1007. https://doi.org/10.3892/ol.2019.11126
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Dong Y, Li X, Pan Y, Du J and Liu D: MicroRNA‑431 serves as a tumor inhibitor in breast cancer through targeting FGF9. Oncol Lett 19: 1001-1007, 2020.
APA
Wang, W., Dong, Y., Li, X., Pan, Y., Du, J., & Liu, D. (2020). MicroRNA‑431 serves as a tumor inhibitor in breast cancer through targeting FGF9. Oncology Letters, 19, 1001-1007. https://doi.org/10.3892/ol.2019.11126
MLA
Wang, W., Dong, Y., Li, X., Pan, Y., Du, J., Liu, D."MicroRNA‑431 serves as a tumor inhibitor in breast cancer through targeting FGF9". Oncology Letters 19.1 (2020): 1001-1007.
Chicago
Wang, W., Dong, Y., Li, X., Pan, Y., Du, J., Liu, D."MicroRNA‑431 serves as a tumor inhibitor in breast cancer through targeting FGF9". Oncology Letters 19, no. 1 (2020): 1001-1007. https://doi.org/10.3892/ol.2019.11126
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team