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Value of imaging findings in predicting post‑operative recurrence of desmoid‑type fibromatosis

  • Authors:
    • Junyan Wang
    • Yijuan Huang
    • Yanbao Sun
    • Yuxi Ge
    • Minming Zhang

  • View Affiliations

  • Published online on: November 21, 2019     https://doi.org/10.3892/ol.2019.11129
  • Pages: 869-875

  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Desmoid‑type fibromatosis is a rare type of soft‑tissue tumor originating from connective tissue of the fascia or aponeurosis, which exhibits aggressive growth, high likelihood of relapse and less frequent distant metastasis. The present study aimed to predict the recurrence rate and time by retrospectively analyzing the clinical data (sex, age and recurrence time), imaging findings [tumor location, maximum diameter, border, computed tomography (CT) enhancement ratio, magnetic resonance enhancement ratio and T2 signal ratio] and pathological features (Ki‑67 and microscopic margin) in a total of 102 cases of pathologically confirmed desmoid‑type fibromatosis. The risk ratio of each factor was calculated using the Cox proportional hazards regression model and the cumulative recurrence‑free survival rate was determined using the Kaplan‑Meier method and the log‑rank test. The cohort comprised of 73 females and 29 males, with mean age of 32.86±12.64 years (range, 6‑78 years). The 1‑year and 2‑year recurrence rate was 31 and 54%, respectively. The median age at recurrence was 29 years. Univariate analysis indicated that sex, maximum tumor diameter, CT enhancement ratio and Ki‑67 had a significant effect on the recurrence time. Furthermore, multivariate analysis revealed that sex, maximum tumor diameter, Ki‑67 and T2 signal ratio were independently associated with the time of recurrence, and the risk ratios were 0.424, 1.100, 1.084 and 1.268, respectively. Therefore, in male patients with a larger maximum tumor diameter, positivity for Ki‑67 and a higher T2 signal ratio, desmoid‑type fibromatosis was more likely to recur after surgery.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang J, Huang Y, Sun Y, Ge Y and Zhang M: Value of imaging findings in predicting post‑operative recurrence of desmoid‑type fibromatosis. Oncol Lett 19: 869-875, 2020
APA
Wang, J., Huang, Y., Sun, Y., Ge, Y., & Zhang, M. (2020). Value of imaging findings in predicting post‑operative recurrence of desmoid‑type fibromatosis. Oncology Letters, 19, 869-875. https://doi.org/10.3892/ol.2019.11129
MLA
Wang, J., Huang, Y., Sun, Y., Ge, Y., Zhang, M."Value of imaging findings in predicting post‑operative recurrence of desmoid‑type fibromatosis". Oncology Letters 19.1 (2020): 869-875.
Chicago
Wang, J., Huang, Y., Sun, Y., Ge, Y., Zhang, M."Value of imaging findings in predicting post‑operative recurrence of desmoid‑type fibromatosis". Oncology Letters 19, no. 1 (2020): 869-875. https://doi.org/10.3892/ol.2019.11129