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Prognostic implications of the BRAF‑V600E mutation in papillary thyroid carcinoma based on a new cut‑off age stratification

  • Authors:
    • Xiaoxiong Gan
    • Fei Shen
    • Xingyan Deng
    • Jianhua Feng
    • Jiabao Lu
    • Wensong Cai
    • Lina Peng
    • Weipeng Zheng
    • Weijia Wang
    • Peidan Huang
    • Zhen Chen
    • Mengli Guo
    • Bo Xu
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China, Department of Colorectal and Anal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China, Department of General Surgery, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518101, P.R. China, Department of Thyroid Surgery, Guangzhou First People's Hospital, Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510180, P.R. China
    Copyright: © Gan et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 631-640
    |
    Published online on: November 21, 2019
       https://doi.org/10.3892/ol.2019.11132
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Abstract

The BRAF‑V600E mutation is the most common and specific oncogenic event known in papillary thyroid carcinoma (PTC). However, it remains controversial whether there is an association between the BRAF‑V600E mutation and clinicopathologically aggressive characteristics of PTC. The purpose of the present retrospective study was to investigate the significance of the BRAF‑V600E mutation in predicting prognostic and aggressive clinicopathological characteristics according to a new age‑based stratification. Clinical data and the BRAF‑V600E mutation status of 475 patients with PTC were downloaded from The Cancer Genome Atlas database. The association between BRAF‑V600E status and clinicopathological characteristics was analyzed by χ2 test or Fisher's exact test. Recurrence‑free survival rate (RFS) was analyzed using the Kaplan‑Meier method. Aggressive clinicopathological factors associated with recurrence were analyzed by Cox multivariate regression. This study was conducted on 219 cases of patients with PTC with a known BRAF‑V600E mutational status. In the ≥55 years age group, BRAF‑V600E was found to be significantly associated with aggressive PTC characteristics, including tumor size, PTC subtype, radioactive iodine (RAI) dose, follow‑up time, recurrence, recurrence risk stage, advanced T stage, advanced N stage and American Joint Committee on Cancer (III/IV) stage (all P<0.05). RFS was analyzed by the log‑rank test and exhibited statistically significant differences in the ≥55 years group (P=0.041), but there was no significant difference in the <55 group (P=0.757), according to the BRAF‑V600E mutation status. The BRAF‑V600E gene was excluded from the recurrence Cox multivariate regression model. The BRAF‑V600E mutation was found to better predict aggressive and recurrent PTC based on age stratification with the cut‑off age of 55 years. The synergistic interaction between BRAF‑V600E mutation and the new age stratification may help clinicians reach the optimal decision in terms of surgical approach and the extent of surgery.
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1 

Davies L and Welch HG: Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg. 140:317–322. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Alzahrani AS and Xing M: Impact of Iymph node metastases identified on central neck dissection (CND) on the recurrence of papillary thyroid cancer: Potential role of BRAFV600E mutation in defining CND. Endocr Relat Cancer. 20:13–22. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Shen X, Liu R and Xing M: A Six-genotype genetic prognostic model for papillary thyroid cancer. Endocr Relat Cancer. 24:41–52. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Xing M: BRAF mutation in thyroid cancer. Endocr Relat Cancer. 12:245–262. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Xing M, Alzahrani AS, Carson KA, Shong YK, Kim TY, Viola D, Elisei R, Bendlová B, Yip L, Mian C, et al: Association between BRAF V600E mutation and recurrence of papillary thyroid cancer. J Clin Oncol. 33:42–50. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Li C, Lee KC, Schneider EB and Zeiger MA: BRAF V600E mutation and its association with clinicopathological features of papillary thyroid cancer: A meta-analysis. J Clin Endocrinol Metab. 97:4559–4570. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Elisei R, Ugolini C, Viola D, Lupi C, Biagini A, Giannini R, Romei C, Miccoli P, Pinchera A and Basolo F: BRAF (V600E) mutation and outcome of patients with papillary thyroid carcinoma: A 15-year median follow-up study. J Clin Endocrinol Metab. 93:3943–3949. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Xing M: Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer. 13:184–199. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Kim TH, Park YJ, Lim JA, Ahn HY, Lee EK, Lee YJ, Kim KW, Hahn SK, Youn YK, Kim KH, et al: The association of the BRAF(V600E) mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer: A meta-analysis. Cancer. 118:1764–1773. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Amin MB: AJCC Cancer Staging Manual. 8th. Springer; New York, NY: 2017, View Article : Google Scholar

11 

Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, et al: 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 26:1–133. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Takacsova E, Kralik R, Waczulikova I, Zavodna K and Kausitz J: A different prognostic value of BRAFV600E mutation positivity in different age groups of patients with papillary thyroid cancer. Neoplasma. 64:156–164. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Tomczak K, Czerwińska P and Wiznerowicz M: The Cancer Genome Atlas (TCGA): An immeasurable source of knowledge. Contemp Oncol (Pozn). 19:A68–A77. 2015.PubMed/NCBI

14 

Eisen MB, Spellman PT, Brown PO and Botstein D: Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA. 95:14863–14868. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Omry-Orbach G: Risk stratification in differentiated thyroid cancer: An ongoing process. Rambam Maimonides Med. 72016.

16 

Luster M, Clarke SE, Dietlein M, Lassmann M, Lind P, Oyen WJ, Tennvall J and Bombardieri E; European Association of Nuclear Medicine (EANM), : Guidelines for radioiodine therapy of differentiated thyroid cancer. Eur J Nucl Med Mol Imaging. 35:1941–1959. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Cohen Y, Xing M, Mambo E, Guo Z, Wu G, Trink B, Beller U, Westra WH, Ladenson PW and Sidransky D: BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst. 95:625–627. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE and Fagin JA: High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res. 63:1454–1457. 2003.PubMed/NCBI

19 

Xing M: BRAF mutation in papillary thyroid cancer: Pathogenic role, molecular bases, and clinical implications. Endocr Rev. 28:742–762. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Shen X, Zhu G, Liu R, Viola D, Elisei R, Puxeddu E, Fugazzola L, Colombo C, Jarzab B, Czarniecka A, et al: Patient age-associated mortality risk is differentiated by BRAF V600E status in papillary thyroid cancer. J Clin Oncol. 36:438–445. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Haymart MR: Understanding the relationship between age and thyroid cancer. Oncologist. 14:216–221. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Sumimoto H, Imabayashi F, Iwata T and Kawakami Y: The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J Exp Med. 203:1651–1656. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Angell TE, Lechner MG, Jang JK, Correa AJ, LoPresti JS and Epstein AL: BRAF V600E in papillary thyroid carcinoma is associated with increased programmed death ligand 1 expression and suppressive immune cell infiltration. Thyroid. 24:1385–1393. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Kim H, Kim TH, Choe JH, Kim JH, Kim JS, Oh YL, Hahn SY, Shin JH, Chi SA, Jung SH, et al: Patterns of initial recurrence in completely resected papillary thyroid carcinoma. Thyroid. 27:908–914. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Suh YJ, Kwon H, Kim SJ, Choi JY, Lee KE, Park YJ, Park DJ and Youn YK: Factors affecting the locoregional recurrence of conventional papillary thyroid carcinoma after surgery: A retrospective analysis of 3381 patients. Ann Surg Oncol. 22:3543–3549. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Xing M: Prognostic utility of BRAF mutation in papillary thyroid cancer. Mol Cell Endocrinol. 321:86–93. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Durante C, Puxeddu E, Ferretti E, Morisi R, Moretti S, Bruno R, Barbi F, Avenia N, Scipioni A, Verrienti A, et al: BRAF mutations in papillary thyroid carcinomas inhibit genes involved in iodine metabolism. J Clin Endocrinol Metab. 92:2840–2843. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Zoghlami A, Roussel F, Sabourin JC, Kuhn JM, Marie JP, Dehesdin D and Choussy O: BRAF mutation in papillary thyroid carcinoma: Predictive value for long-term prognosis and radioiodine sensitivity. Eur Ann Otorhinolaryngol Head Neck Dis. 131:7–13. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gan X, Shen F, Deng X, Feng J, Lu J, Cai W, Peng L, Zheng W, Wang W, Huang P, Huang P, et al: Prognostic implications of the BRAF‑V600E mutation in papillary thyroid carcinoma based on a new cut‑off age stratification. Oncol Lett 19: 631-640, 2020.
APA
Gan, X., Shen, F., Deng, X., Feng, J., Lu, J., Cai, W. ... Xu, B. (2020). Prognostic implications of the BRAF‑V600E mutation in papillary thyroid carcinoma based on a new cut‑off age stratification. Oncology Letters, 19, 631-640. https://doi.org/10.3892/ol.2019.11132
MLA
Gan, X., Shen, F., Deng, X., Feng, J., Lu, J., Cai, W., Peng, L., Zheng, W., Wang, W., Huang, P., Chen, Z., Guo, M., Xu, B."Prognostic implications of the BRAF‑V600E mutation in papillary thyroid carcinoma based on a new cut‑off age stratification". Oncology Letters 19.1 (2020): 631-640.
Chicago
Gan, X., Shen, F., Deng, X., Feng, J., Lu, J., Cai, W., Peng, L., Zheng, W., Wang, W., Huang, P., Chen, Z., Guo, M., Xu, B."Prognostic implications of the BRAF‑V600E mutation in papillary thyroid carcinoma based on a new cut‑off age stratification". Oncology Letters 19, no. 1 (2020): 631-640. https://doi.org/10.3892/ol.2019.11132
Copy and paste a formatted citation
x
Spandidos Publications style
Gan X, Shen F, Deng X, Feng J, Lu J, Cai W, Peng L, Zheng W, Wang W, Huang P, Huang P, et al: Prognostic implications of the BRAF‑V600E mutation in papillary thyroid carcinoma based on a new cut‑off age stratification. Oncol Lett 19: 631-640, 2020.
APA
Gan, X., Shen, F., Deng, X., Feng, J., Lu, J., Cai, W. ... Xu, B. (2020). Prognostic implications of the BRAF‑V600E mutation in papillary thyroid carcinoma based on a new cut‑off age stratification. Oncology Letters, 19, 631-640. https://doi.org/10.3892/ol.2019.11132
MLA
Gan, X., Shen, F., Deng, X., Feng, J., Lu, J., Cai, W., Peng, L., Zheng, W., Wang, W., Huang, P., Chen, Z., Guo, M., Xu, B."Prognostic implications of the BRAF‑V600E mutation in papillary thyroid carcinoma based on a new cut‑off age stratification". Oncology Letters 19.1 (2020): 631-640.
Chicago
Gan, X., Shen, F., Deng, X., Feng, J., Lu, J., Cai, W., Peng, L., Zheng, W., Wang, W., Huang, P., Chen, Z., Guo, M., Xu, B."Prognostic implications of the BRAF‑V600E mutation in papillary thyroid carcinoma based on a new cut‑off age stratification". Oncology Letters 19, no. 1 (2020): 631-640. https://doi.org/10.3892/ol.2019.11132
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