Open Access

Clinical features and prognostic factors in patients with esophageal cancer with bone metastasis

  • Authors:
    • Yoshinori Imura
    • Sachiko Yamamoto
    • Toru Wakamatsu
    • Takaaki Tanaka
    • Hironari Tamiya
    • Keijiro Sugimura
    • Hiroshi Miyata
    • Ryu Ishihara
    • Masahiko Yano
    • Norifumi Naka
  • View Affiliations

  • Published online on: November 22, 2019     https://doi.org/10.3892/ol.2019.11142
  • Pages: 717-724
  • Copyright: © Imura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

There have been few reports on bone metastases (BMs) from esophageal cancer (EC). The aim of the present study was to investigate the clinicopathological features and prognostic factors in patients with EC with BMs. The present study retrospectively collected data from 58 patients with BMs from EC who were treated at our institution between 2007 and 2016. Patient, tumor and BM‑associated characteristics were analyzed. Kaplan‑Meier survival curves were constructed and analyzed using the univariate log‑rank test. Multivariate analyses were conducted using the Cox proportional hazards model. The median patient age was 67 years (range, 39‑84 years). Multiple BMs were detected in 38 patients (65.5%) and 52 patients (89.7%) exhibited osteolytic BMs. Skeletal‑related events (SREs) occurred in 53 patients (91.4%). The one‑year overall survival (OS) was 25.3%, and the median OS was 5 months (range, 0‑54). Univariate analyses revealed that performance status, visceral or brain metastasis, serum carcinoembryonic antigen (CEA), C‑reactive protein, albumin level, and receipt of chemotherapy following BM diagnosis were significantly associated with OS. Multivariate analyses of these factors demonstrated that higher serum CEA levels and no chemotherapy were significant risk factors for poor OS. Multiple osteolytic BMs are frequently observed in patients with EC with BMs, and SREs commonly occur. The prognoses of patients with EC with BMs are poor, but chemotherapy administration following the BM diagnosis should confer a survival benefit.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Imura Y, Yamamoto S, Wakamatsu T, Tanaka T, Tamiya H, Sugimura K, Miyata H, Ishihara R, Yano M, Naka N, Naka N, et al: Clinical features and prognostic factors in patients with esophageal cancer with bone metastasis. Oncol Lett 19: 717-724, 2020
APA
Imura, Y., Yamamoto, S., Wakamatsu, T., Tanaka, T., Tamiya, H., Sugimura, K. ... Naka, N. (2020). Clinical features and prognostic factors in patients with esophageal cancer with bone metastasis. Oncology Letters, 19, 717-724. https://doi.org/10.3892/ol.2019.11142
MLA
Imura, Y., Yamamoto, S., Wakamatsu, T., Tanaka, T., Tamiya, H., Sugimura, K., Miyata, H., Ishihara, R., Yano, M., Naka, N."Clinical features and prognostic factors in patients with esophageal cancer with bone metastasis". Oncology Letters 19.1 (2020): 717-724.
Chicago
Imura, Y., Yamamoto, S., Wakamatsu, T., Tanaka, T., Tamiya, H., Sugimura, K., Miyata, H., Ishihara, R., Yano, M., Naka, N."Clinical features and prognostic factors in patients with esophageal cancer with bone metastasis". Oncology Letters 19, no. 1 (2020): 717-724. https://doi.org/10.3892/ol.2019.11142