Open Access

NRSN2 promotes breast cancer metastasis by activating PI3K/AKT/mTOR and NF‑κB signaling pathways

  • Authors:
    • Fei Ren
    • Wei Zhang
    • Shuai Lu
    • Hong Ren
    • Yantong Guo
  • View Affiliations

  • Published online on: November 28, 2019     https://doi.org/10.3892/ol.2019.11152
  • Pages: 813-823
  • Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Breast cancer is a leading cause of cancer‑associated mortality globally amongst gynecologic tumors due to aggressive metastasis. A previous study reported that neurensin‑2 (NRSN2) was implicated in human cancer cells, and that NRSN2 gene and protein expression levels were significantly upregulated in human breast cancer tissues compared with adjacent non‑tumor tissues. The purpose of the present study was to analyze the role of NRSN2 in the metastasis of breast cancer cells and explore its potential mechanism. Reverse transcription‑quantitative PCR, MTT, western blotting and immunohistochemistry was used to analyze the role of NRSN2 both in vitro and in vivo. The present study demonstrated that NRSN2 knockdown inhibited the proliferation, migration and invasion of breast cancer cells in vitro. NRSN2 upregulation promoted breast cancer cell proliferation and tissue growth in vitro and in vivo. In addition, the results demonstrated that the regulatory effects of NRSN2 on breast cancer cells were associated with PI3K/AKT/mTOR and NF‑κB signaling pathway dysregulation. Furthermore, NRSN2 overexpression in mice significantly promoted breast cancer cell proliferation. In conclusion, the results from the present study indicated that NRSN2 may be considered as a novel oncogenic protein and may represent a potential therapeutic target for breast cancer.
View Figures
View References

Related Articles

Journal Cover

January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ren F, Zhang W, Lu S, Ren H and Guo Y: NRSN2 promotes breast cancer metastasis by activating PI3K/AKT/mTOR and NF‑κB signaling pathways. Oncol Lett 19: 813-823, 2020
APA
Ren, F., Zhang, W., Lu, S., Ren, H., & Guo, Y. (2020). NRSN2 promotes breast cancer metastasis by activating PI3K/AKT/mTOR and NF‑κB signaling pathways. Oncology Letters, 19, 813-823. https://doi.org/10.3892/ol.2019.11152
MLA
Ren, F., Zhang, W., Lu, S., Ren, H., Guo, Y."NRSN2 promotes breast cancer metastasis by activating PI3K/AKT/mTOR and NF‑κB signaling pathways". Oncology Letters 19.1 (2020): 813-823.
Chicago
Ren, F., Zhang, W., Lu, S., Ren, H., Guo, Y."NRSN2 promotes breast cancer metastasis by activating PI3K/AKT/mTOR and NF‑κB signaling pathways". Oncology Letters 19, no. 1 (2020): 813-823. https://doi.org/10.3892/ol.2019.11152