Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Serum coiled‑coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma

  • Authors:
    • Ravinnipa Chanakankun
    • Tanakorn Proungvitaya
    • Daraporn Chua‑On
    • Temduang Limpaiboon
    • Sittiruk Roytrakul
    • Apinya Jusakul
    • Attapol Titapun
    • Apiwat Jarearnrat
    • Siriporn Proungvitaya
  • View Affiliations / Copyright

    Affiliations: Centre of Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Muang, Khon Kaen 40002, Thailand, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Khlong Luang, Pathumthani 12120, Thailand, Department of Surgery, Faculty of Medicine, Khon Kaen University, Muang, Khon Kaen 40002, Thailand
    Copyright: © Chanakankun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 930-942
    |
    Published online on: November 29, 2019
       https://doi.org/10.3892/ol.2019.11162
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Coiled‑coil domain containing 25 (CCDC25) was previously reported to be upregulated in cholangiocarcinoma (CCA) tissues compared with adjacent normal tissues. The present study investigated whether serum CCDC25 level may be used as a potential marker for the diagnosis of CCA. Bioinformatics tools were used to reveal that CCDC25 is secreted into plasma/serum via a non‑conventional pathway, which secretes proteins independently from the endoplasmic reticulum/golgi complex, but is yet to be fully elucidated. Subsequently, the CCDC25 levels in the sera of patients with CCA (n=141), patients with benign biliary disease (BBD; n=53) and healthy controls (HC; n=72) were measured using a quantitative dot blot assay based on the standard curve created using recombinant CCDC25 protein. The results demonstrated that the serum CCDC25 level in the CCA group (0.28±0.06 ng/µl) was significantly higher compared with that in the BBD (0.15±0.03 ng/µl) or HC (0.0017±0.0008 ng/µl) groups. Serum CCDC25 level provided an improved resolution (P=0.0001) compared with carcinoembryonic antigen (P=0.098) or carbohydrate antigen 19‑9 (P=0.271) for the differential diagnosis between BBD and CCA. Receiver operating characteristic curve analysis revealed high sensitivity and specificity of serum CCDC25 level to differentiate between patients with CCA and HC (93.0 and 100%, respectively), and also to differentiate between patients with CCA and patients with BBD (75.0 and 84.0%, respectively). CCDC25 expression was further investigated in 23 CCA tissues, and CCDC25 expression in cancer tissues was moderately correlated with the serum CCDC25 level (r2=0.52, P=0.01). Among patients with CCA, serum CCDC25 level was significantly higher in patients with non‑metastatic CCA compared with patients with metastatic CCA. Correspondingly, a higher serum CCDC25 level was associated with a longer overall survival time in patients with CCA. In conclusion, serum CCDC25 level may be a promising screening and diagnostic marker for the differential diagnosis of CCA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Sripa B and Pairojkul C: Cholangiocarcinoma: Lessons from Thailand. Curr Opin Gastroenterol. 24:349–356. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Lozada ME, Chaiteerakij R and Roberts LR: Screening for hepatocellular carcinoma and cholangiocarcinoma: Can biomarkers replace imaging? Curr Hepatol Rep. 14:128–138. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Razumilava N, Gores GJ and Lindor KD: Cancer surveillance in patients with primary sclerosing cholangitis. Hepatology. 54:1842–1852. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Ong S, Sachdeva A, Garcea G, Gravante G, Metcalfe M, Lloyd D, Berry D and Dennison A: Elevation of carbohydrate antigen 19.9 in benign hepatobiliary conditions and its correlation with serum bilirubin concentration. Dig Dis Sci. 53:3213–3217. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Silsirivanit A, Araki N, Wongkham C, Pairojkul C, Narimatsu Y, Kuwahara K, Narimatsu H, Wongkham S and Sakaguchi N: A novel serum carbohydrate marker on mucin 5AC: Values for diagnostic and prognostic indicators for cholangiocarcinoma. Cancer. 117:3393–3403. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Leelawat K, Narong S, Wannaprasert J and Ratanashu-ek T: Prospective study of MMP7 serum levels in the diagnosis of cholangiocarcinoma. World J Gastroenterol. 16:4697–4703. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Wongkham S and Silsirivanit A: State of serum markers for detection of cholangiocarcinoma. Asian Pac J Cancer Prev. 13 (Suppl):S17–S27. 2012.

8 

Apweiler R, Bairoch A, Wu CH, Barker WC, Boeckmann B, Ferro S, Gasteiger E, Huang H, Lopez R, Magrane M, et al: UniProt: The universal protein knowledgebase. Nucleic Acids Res. 32((Database Issue)): D115–D119. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, et al: Proteomics: Tissue-based map of the human proteome. Science. 347:12604192015. View Article : Google Scholar : PubMed/NCBI

10 

Proungvitaya S, Klinthong W, Proungvitaya T, Limpaiboon T, Jearanaikoon P, Roytrakul S, Wongkham C, Nimboriboonporn A and Wongkhamand S: High expression of CCDC25 in cholangiocarcinoma tissue samples. Oncol Lett. 14:2566–2572. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Suresh K and Chandrashekara S: Sample size estimation and power analysis for clinical research studies. J Hum Reprod Sci. 5:7–13. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Almagro Armenteros JJ, Tsirigos KD, Sønderby CK, Petersen TN, Winther O, Brunak S, von Heijne G and Nielsen H: SignalP 5.0 improves signal peptide predictions using deep neural networks. Nat Biotechnol. 37:420–423. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Bendtsen JD, Jensen LJ, Blom N, Von Heilne G and Brunak S: Feature-based prediction of non-classical and leaderless protein secretion. Protein Eng Des Sel. 17:349–356. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Nanjappa V, Thomas JK, Marimuthu A, Muthusamy B, Radhakrishnan A, Sharma R, Ahmad Khan A, Balakrishnan L, Sahasrabuddhe NA, Kumar S, et al: Plasma proteome database as a resource for proteomics research: 2014 update. Nucleic acid Res. 42:D959–D965. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Kuhn M, Szklarczyk D, Pletscher-Frankild S, Blicher TH, von Mering C, Jensen LJ and Bork P: STITCH 4: Integration of protein-chemical interactions with user data. Nucleic Acids Res. 42((Database Issue)): D401–D407. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Wu L, Huang P, Wang F, Li D, Xie E, Zhang Y and Pan S: Relationship between serum CA19-9 and CEA levels and prognosis of pancreatic cancer. Ann Transl Med. 3:3282015.PubMed/NCBI

17 

Taylor SC, Berkelman T, Yadav G and Hammond M: A defined methodology for reliable quantification of western blot data. Mol Biotechnol. 55:217–226. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Fang R, Wey A, Bobbili NK, Leke RFG, Taylor DW and Chen JJ: An analytical approach to reduce between-plate variation in multiplex assays that measure antibodies to plasmodium falciparum antigens. Malar J. 16:2872017. View Article : Google Scholar : PubMed/NCBI

19 

Ma HY, Lu YN, Marchbanks PA, Folger SG, Strom BL, McDonald JA, Simon MS, Weiss LK, Malone KE, Burkman RT, et al: Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women. Breast Cancer Res. 15:R902013. View Article : Google Scholar : PubMed/NCBI

20 

Farrah T, Deutsch EW, Omenn GS, Campbell DS, Sun Z, Bletz JA, Mallick P, Katz JE, Malmström J, Ossola R, et al: A high-confidence human plasma proteome reference set with estimated concentrations in PeptideAtlas. Mol Cell Proteomics. 10:M110.006353. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Schober P, Boer C and Schwarte LA: Correlation coefficients: Appropriate use and interpretation. Anesth Analg. 126:1763–1768. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Rabouille C: Pathways of unconventional protein secretion. Trends Cell Biol. 27:230–240. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Stone W, Grabias B, Lanke K, Zheng H, Locke E, Diallo D, Birkett A, Morin M, Bousema T and Kumarand S: A comparison of plasmodium falciparum circumsporozoite protein-based slot blot and ELISA immuno-assays for oocyst detection in mosquito homogenates. Malar J. 14:4512015. View Article : Google Scholar : PubMed/NCBI

24 

Kamel HH, Saad GA and Sarhan RM: Dot-blot immunoassay of Fasciola gigantica infection using 27 kDa and adult worm regurge antigens in Egyptian patients. Korean J Parasitol. 51:177–182. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Falconar AK and Romero-Vivas CM: A simple, inexpensive, robust and sensitive dot-blot assay for equal detection of the nonstructural-1 glycoprotein of all dengue virus serotypes. Virol J. 10:1262013. View Article : Google Scholar : PubMed/NCBI

26 

Vera-Cabrera L, Rendon A, Diaz-Rodriguez M, Handzel V and Laszlo A: Dot blot assay for detection of antidiacyltrehalose antibodies in tuberculous patients. Clin Diagn Lab Immunol. 6:686–689. 1999.PubMed/NCBI

27 

Tian G, Tang F, Yang C, Zhang W, Bergquist J, Wang B, Mi J and Zhang J: Quantitative dot blot analysis (QDB), a versatile high throughput immunoblot method. Oncotarget. 8:58553–58562. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Abdullah MI, Lee CC, Junit SM, Ng KL and Hashim OH: Tissue and serum samples of patients with papillary thyroid cancer with and without benign background demonstrate different altered expression of proteins. Peer J. 4:e24502016. View Article : Google Scholar : PubMed/NCBI

29 

Grzesiak K, Rył A, Baranowska-Bosiacka I, Rotter I, Dołęgowska B, Słojewski M, Sipak-Szmigiel O, Ratajczak W, Lubkowska A, Metryka E, et al: Comparison between selected hormone and protein levels in serum and prostate tissue homogenates in men with benign prostatic hyperplasia and metabolic disorders. Clin Interv Aging. 13:1375–1382. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Edoo MIA, Chutturghoon VK, Wusu-Ansah GK, Zhu H, Zhen TY, Xie HY and Zheng SS: Serum biomarkers AFP, CEA and CA19-9 combined detection for early diagnosis of hepatocellular carcinoma. Iran J Public Health. 48:314–322. 2019.PubMed/NCBI

31 

Zeng X and Tao H: Diagnostic and prognostic serum marker of cholangiocarcinoma (review). Oncol Lett. 9:3–8. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Loosen SH, Roderburg C, Kauertz KL, Koch A, Vucur M, Schneider AT, Binnebösel M, Ulmer TF, Lurje G, Schoening W, et al: CEA but not CA19-9 is an independent prognostic factor in patients undergoing resection of cholangiocarcinoma. Sci Rep. 7:169752017. View Article : Google Scholar : PubMed/NCBI

33 

Tshering G, Dorji PW, Chaijaroenkul W and Na-Bangchang K: Biomarkers for the diagnosis of cholangiocarcinoma: A systematic review. Am J Trop Med Hyg. 98:1788–1797. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Cuenco J, Wehnert N, Blyuss O, Kazarian A, Whitwell HJ, Menon U, Dawnay A, Manns MP, Pereira SP and Timms JF: Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholangitis. Oncotarget. 9:17430–17442. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Unal D, Eroglu C, Tasdemir A, Karaman H, Kurtul N, Oguz A, Goksu S and Kaphen B: Is human kallikrein 11 in non-small cell lung cancer treated chemoradiotherapy associated with survival? Cancer Res Treat. 48:98–105. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Turner BC, Krajewski S, Krajewska M, Takayama S, Gumbs AA, Carter D, Rebbeck RT, Haffty BG and Reed JC: BAG-1: A novel biomarker predicting long-term survival in early-stage breast cancer. J Clin Oncol. 19:992–1000. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Caron B, Nair A, Averous G, Nguimpi-Tambou M, Duluc I, Addeo P, Bachellier P, Barnard D, Freund JN and Reimund JM: CDX2 is a biomarker of better prognosis in pancreatic ductal adenocarcinoma (PDA). Gastroenterology. 152 (Suppl 1):S275–S276. 2017. View Article : Google Scholar

38 

Lowitz BB and Casciata DA: Principles of medical oncology and cancer biology [Internet]. Philadelphia, PA: Lippincott Williams & Wilkins; 2000, [visited 2018 Sep 10]. http://www.justmed.eu/files/st/onPubMed/NCBI

39 

Qu Z, Li D, Xu H, Zhang R, Li B, Sun C, Dong W and Zhang Y: CUL4B, NEDD4, and UGT1As involve in the TGF-β signaling in hepatocellular carcinoma. Ann Hepatol. 15:568–576. 2016.

40 

Walesky C and Apte U: Role of hepatocyte nuclear factor 4α (HNF4α) in cell proliferation and cancer. Gene Expr. 16:101–108. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Roessler S, Long EL, Budhu A, Chen Y, Zhao X, Ji J, Walker R, Jia HL, Ye QH, Qin LX, et al: Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. Gastroenterology. 142:957–966.e12. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Hsu CM, Hsu YA, Tsai Y, Shieh FK, Huang SH, Wan L and Tsai FJ: Emodin inhibits the growth of hepatoma cells: Finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells. Biochem Biophys Res Commun. 392:473–478. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Kido T and Lau YF: Roles of the Y chromosome genes in human cancers. Asian J Androl. 17:373–380. 2015.PubMed/NCBI

44 

Zhang S, Li J, Zhou G, Mu D, Yan J, Xing J, Yao Z, Sheng H, Li D, Lv C, et al: Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladder cancer. Tumor Biol. 37:5165–5170. 2016. View Article : Google Scholar

45 

Pang B, Wu N, Guan R, Pang L, Li X, Li S, Tang L, Guo Y, Chen J, Sun D, et al: Overexpression of RCC2 enhances cell motility and promotes tumor metastasis in lung adenocarcinoma by inducing epithelial–mesenchymal transition. Clin Cancer Res. 23:5598–5610. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chanakankun R, Proungvitaya T, Chua‑On D, Limpaiboon T, Roytrakul S, Jusakul A, Titapun A, Jarearnrat A and Proungvitaya S: Serum coiled‑coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma. Oncol Lett 19: 930-942, 2020.
APA
Chanakankun, R., Proungvitaya, T., Chua‑On, D., Limpaiboon, T., Roytrakul, S., Jusakul, A. ... Proungvitaya, S. (2020). Serum coiled‑coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma. Oncology Letters, 19, 930-942. https://doi.org/10.3892/ol.2019.11162
MLA
Chanakankun, R., Proungvitaya, T., Chua‑On, D., Limpaiboon, T., Roytrakul, S., Jusakul, A., Titapun, A., Jarearnrat, A., Proungvitaya, S."Serum coiled‑coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma". Oncology Letters 19.1 (2020): 930-942.
Chicago
Chanakankun, R., Proungvitaya, T., Chua‑On, D., Limpaiboon, T., Roytrakul, S., Jusakul, A., Titapun, A., Jarearnrat, A., Proungvitaya, S."Serum coiled‑coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma". Oncology Letters 19, no. 1 (2020): 930-942. https://doi.org/10.3892/ol.2019.11162
Copy and paste a formatted citation
x
Spandidos Publications style
Chanakankun R, Proungvitaya T, Chua‑On D, Limpaiboon T, Roytrakul S, Jusakul A, Titapun A, Jarearnrat A and Proungvitaya S: Serum coiled‑coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma. Oncol Lett 19: 930-942, 2020.
APA
Chanakankun, R., Proungvitaya, T., Chua‑On, D., Limpaiboon, T., Roytrakul, S., Jusakul, A. ... Proungvitaya, S. (2020). Serum coiled‑coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma. Oncology Letters, 19, 930-942. https://doi.org/10.3892/ol.2019.11162
MLA
Chanakankun, R., Proungvitaya, T., Chua‑On, D., Limpaiboon, T., Roytrakul, S., Jusakul, A., Titapun, A., Jarearnrat, A., Proungvitaya, S."Serum coiled‑coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma". Oncology Letters 19.1 (2020): 930-942.
Chicago
Chanakankun, R., Proungvitaya, T., Chua‑On, D., Limpaiboon, T., Roytrakul, S., Jusakul, A., Titapun, A., Jarearnrat, A., Proungvitaya, S."Serum coiled‑coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma". Oncology Letters 19, no. 1 (2020): 930-942. https://doi.org/10.3892/ol.2019.11162
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team