Open Access

In silico identification of EP400 and TIA1 as critical transcription factors involved in human hepatocellular carcinoma relapse

  • Authors:
    • Weiguo Hong
    • Yan Hu
    • Zhenping Fan
    • Rong Gao
    • Ruichuang Yang
    • Jingfeng Bi
    • Jun Hou
  • View Affiliations

  • Published online on: December 2, 2019     https://doi.org/10.3892/ol.2019.11171
  • Pages: 952-964
  • Copyright: © Hong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer‑associated mortality worldwide. Transcription factors (TFs) are crucial proteins that regulate gene expression during cancer progression; however, the roles of TFs in HCC relapse remain unclear. To identify the TFs that drive HCC relapse, the present study constructed co‑expression network and identified the Tan module the most relevant to HCC relapse. Numerous hub TFs (highly connected) were subsequently obtained from the Tan module according to the intra‑module connectivity and the protein‑protein interaction network connectivity. Next, E1A‑binding protein p400 (EP400) and TIA1 cytotoxic granule associated RNA binding protein (TIA1) were identified as hub TFs differentially connected between the relapsed and non‑relapsed subnetworks. In addition, zinc finger protein 143 (ZNF143) and Yin Yang 1 (YY1) were also identified by using the plugin iRegulon in Cytoscape as master upstream regulatory elements, which could potentially regulate expression of the genes and TFs of the Tan module, respectively. The Kaplan‑Meier (KM) curves obtained from KMplot and Gene Expression Profiling Interactive Analysis tools confirmed that the high expression of EP400 and TIA1 were significantly associated with shorter relapse‑free survival and disease‑free survival of patients with HCC. Furthermore, the KM curves from the UALCAN database demonstrated that high EP400 expression significantly reduced the overall survival of patients with HCC. EP400 and TIA1 may therefore serve as potential prognostic and therapeutic biomarkers.
View Figures
View References

Related Articles

Journal Cover

January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hong W, Hu Y, Fan Z, Gao R, Yang R, Bi J and Hou J: In silico identification of EP400 and TIA1 as critical transcription factors involved in human hepatocellular carcinoma relapse. Oncol Lett 19: 952-964, 2020
APA
Hong, W., Hu, Y., Fan, Z., Gao, R., Yang, R., Bi, J., & Hou, J. (2020). In silico identification of EP400 and TIA1 as critical transcription factors involved in human hepatocellular carcinoma relapse. Oncology Letters, 19, 952-964. https://doi.org/10.3892/ol.2019.11171
MLA
Hong, W., Hu, Y., Fan, Z., Gao, R., Yang, R., Bi, J., Hou, J."In silico identification of EP400 and TIA1 as critical transcription factors involved in human hepatocellular carcinoma relapse". Oncology Letters 19.1 (2020): 952-964.
Chicago
Hong, W., Hu, Y., Fan, Z., Gao, R., Yang, R., Bi, J., Hou, J."In silico identification of EP400 and TIA1 as critical transcription factors involved in human hepatocellular carcinoma relapse". Oncology Letters 19, no. 1 (2020): 952-964. https://doi.org/10.3892/ol.2019.11171