Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Comparison of nodal irradiation dose using radiotherapy for patients with thoracic esophageal cancer

  • Authors:
    • Ni Zhang
    • Min Gu
    • Jiahao Wang
    • Shixiu Wu
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang 310002, P.R. China
  • Pages: 1042-1050
    |
    Published online on: December 3, 2019
       https://doi.org/10.3892/ol.2019.11178
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to compare incidental nodal irradiation (INI) doses using volume‑modulated arc therapy (VMAT), 5‑field intensity‑modulated radiotherapy (5F‑IMRT) and 3D‑conformal radiotherapy (3D‑CRT) treatment plans for patients with thoracic esophageal cancer (EC). A total of 15 patients with thoracic EC were selected for participation between October 2016 and July 2017 at the Hangzhou Cancer Hospital. Regional lymph nodal stations were contoured according to 3D CT‑based images of the Japan Esophageal Society Guidelines. All patients were treated with 60 Gy using VMAT, 5F‑IMRT and 3D‑CRT plans. Dose‑volume histograms of planning target volume (PTV), lung, heart, spinal cord and incidental nodal irradiation were compared between the three plans. 5F‑IMRT was superior in PTV_V95% (the volume of the PTV receiving 95% of the prescription dose, P=0.003) and the VMAT plan was best in terms of conformal index (P=0.005). V20 and V30 were reduced by 10.7‑22.6% (P=0.002) and 12.8‑21% (P=0.026), respectively, in normal lung tissue using the VMAT plan. 5F‑IMRT demonstrated the lowest maximum dose (Dmax) for the spinal cord (P=0.037). For the INI, 3D‑CRT exhibited the highest equivalent uniform dose (EUD) values for 106pre (P=0.014) and 106tb‑L (P=0.03) in upper‑thoracic EC. The mean EUD of all lymph nodal regions in middle‑thoracic EC were >40 Gy in VMAT and 5F‑IMRT plans; the VMAT plan had higher EUD values in lower‑thoracic EC compared with 5F‑IMRT, 3D‑CRT plans for INI. VMAT were comparable to the 5F‑IMRT plan with respect to dosimetric characteristics for planning and INI doses to thoracic nodal levels NO 105‑112 are considerable for thoracic EC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

American Cancer Society. Esophageal cancer, . Atlanta, GA: American Cancer Society; 2007

2 

Djarv T, Lagergren J, Blazeby JM and Lagergren P: Long-term health-related quality of life following surgery for esophageal cancer. Br J Surg. 95:1121–1126. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Minsky BD, Pajak TF, Ginsberg RJ, Pisansky TM, Martenson J, Komaki R, Okawara G, Rosenthal SA and Kelsen DP: INT0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: High-dose versus standard-dose radiation therapy. J Clin Oncol. 20:1167–1174. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Cooper JS, Guo MD, Herskovic A, Macdonald JS, Martenson JA Jr, Al-Sarraf M, Byhardt R, Russell AH, Beitler JJ, Spencer S, et al: Chemoradiotherapy of locally advanced esophageal cancer: Long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation therapy oncology group. JAMA. 281:1623–1627. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Coia LR, Minsky BD, Berkey BA, John MJ, Haller D, Landry J, Pisansky TM, Willett CG, Hoffman JP, Owen JB and Hanks GE: Outcome of patients receiving radiation for cancer of the esophagus: Results of the 1992–1994 patterns of care study. J Clin Oncol. 18:455–462. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Smith TJ, Ryan LM, Douglass HO Jr, Haller DG, Dayal Y, Kirkwood J, Tormey DC, Schutt AJ, Hinson J and Sischy B: Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus: A study of the Eastern Cooperative Oncology Group. Int J Radiat Oncol Biol Phys. 42:269–276. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Muijs C, Smit J, Karrenbeld A, Beukema J, Mul V, van Dam G, Hospers G, Kluin P, Langendijk J and Plukker J: Residual tumor after neoadjuvant chemoradiation outside the radiation therapy target volume: A new prognostic factor for survival in esophageal cancer. Int J Radiat Oncol Biol Phys. 88:845–852. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Ji K, Zhao L, Yang C, Meng M and Wang P: Three-dimensional conformal radiation for esophageal squamous cell carcinoma with involved-field irradiation may deliver considerable doses of incidental nodal irradiation. Radiat Oncol. 7:2002012. View Article : Google Scholar : PubMed/NCBI

9 

Cozzi L, Dinshaw KA, Shrivastava SK, Mahantshetty U, Engineer R, Deshpande DD, Jamema SV, Vanetti E, Clivio A, Nicolini G and Fogliata A: A treatment planning study comparing volumetric arc modulation with rapidArc and fixed field IMRT for cervix uteri radiotherapy. Radiother. Oncol. 89:180–191. 2008.

10 

Guckenberger M, Richter A, Krieger T, Wilbert J, Baier K and Flentje M: Is a single arc sufficient in volumetric-modulated arc therapy (VMAT) for complex-shaped target volumes? Radiother. Oncol. 93:259–265. 2009.

11 

Shaffer R, Morris WJ, Moiseenko V, Welsh M, Crumley C, Nakano S, Schmuland M, Pickles T and Otto K: Volumetric modulated arc therapy and conventional intensity-modulated radiotherapy for simultaneous maximal intraprostatic Boost: A planning comparison study. Clin Oncol (R Coll Radiol). 21:401–407. 2009. View Article : Google Scholar : PubMed/NCBI

12 

ICRU Report 62, . Prescribing, Recording, and Reporting Photon Beam Therapy. (Supplement to ICRU Report 50):21:1999.

13 

Japanese Society for Esophageal Disease, . Guide lines for the clinical and pathologic studies for carcinoma of the esophagus. Jpn J Surg. 1976:79–86. 1976.

14 

Japan Esophageal Society, . Japanese classification of esophageal cancer, 11th Edition: part I. Esophagus. 6:71–94. 2009. View Article : Google Scholar

15 

Harris KM, Adams H, Lloyd DC and Harvey DJ: The effect on apparent size of simulated pulmonary nodules of using three standard CT window settings. Clin Radiol. 47:241–244. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Otto K: Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys. 35:310–317. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Fogliata A, Yartsev S, Nicolini G, Clivio A, Vanetti E, Wyttenbach R, Bauman G and Cozzi L: On the performances of intensity modulated protons, RapidArc, helical tomotherapy for selected paediatric cases. Radiat Oncol. 4:22009. View Article : Google Scholar : PubMed/NCBI

18 

Fogliata A, Clivio A, Nicolini G, Vanetti E and Cozzi L: Intensity modulation with photons for benign intracranial tumours: A planning comparison of volumetric single arc, helical arc and fixed gantry techniques. Radiother Oncol. 89:254–262. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Fenkell L, Kaminsky I, Breen S, Huang S, Van Prooijen M and Ringash J: Dosimetric comparison of IMRT vs. 3D conformal radiotherapy in the treatment of cancer of the cervical esophagus. Radiother. Oncol. 89:287–291. 2009.

20 

Yin Y, Chen J, Xing L, Dong X, Liu T, Lu J and Yu J: Applications of IMAT in cervical esophageal cancer radiotherapy: A comparison with fixed-field IMRT in dosimetry and implementation. J Appl Clin Med Phys. 12:48–57. 2011. View Article : Google Scholar

21 

Van Benthuysen L, Hales L and Podgorsak MB: Volumetric modulated arc therapy vs. IMRT for the treatment of distal esophageal cancer. Med Dosim. 36:404–409. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Shimada H, Kitabayashi H, Nabeya Y, Okazumi S, Matsubara H, Funami Y, Miyazawa Y, Shiratori T, Uno T, Itoh H and Ochiai T: Treatment response and prognosis of patients after recurrence of esophageal cancer. Surgery. 133:24–31. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Greenlee RT, Hill-Harmon MB, Murray T and Thun M: Cancer statistics, 2001. CA Cancer J Clin. 51:15–36. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Nakagawa S, Kanda T, Kosugi S, Ohashi M, Suzuki T and Hatakeyama K: Recurrence pattern of squamous cell carcinoma of the thoracic esophagus after extended radical esophagectomy with three-field lymphadenectomy. J Am Coll Surg. 198:205–211. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Hsu FM, Lee JM, Huang PM, Lin CC, Hsu CH, Tsai YC, Lee YC and Chia-Hsien Cheng J: Retrospective analysis of outcome differences in preoperative concurrent chemoradiation with or without elective nodal irradiation for esophageal squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 81:593–599. 2011. View Article : Google Scholar

26 

Zhao KL, Ma JB, Liu G, Wu KL, Shi XH and Jiang GL: Three-dimensional conformal radiation therapy for esophageal squamous cell carcinoma: Is elective nodal irradiation necessary? Int J Radiation Oncology Biol Phys. 76:446–451. 2010. View Article : Google Scholar

27 

Welsh J, Settle SH, Amini A, Xiao L, Suzuki A, Hayashi Y, Hofstetter W, Komaki R, Liao Z and Ajani JA: Failure patterns in patients with esophageal cancer treated with definitive chemoradiation. Cancer. 118:2632–2640. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Zhao L, Chen L, Ten Haken R, Chetty I, Chapet O, Hayman JA and Kong FM: Three-dimensional conformal radiation may deliver considerable dose of incidental nodal irradiation in patients with early stage node-negative non-small cell lung cancer when the tumor is large and centrally located. Radiother Oncol. 82:153–159. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Kepka L, Maciejewski B and Withers RH: Does incidental irradiation with doses below 50 Gy effectively reduce isolated nodal failures in non-small-cell lung cancer: Dose-response relationship. Int J Radiat Oncol Biol Phys. 73:1391–1396. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Huang W, Li B, Gong H, Yu J, Sun H, Zhou T, Zhang Z and Liu X: Pattern of lymph node metastases and its implication in radiotherapeutic clinical target volume in patients with thoracic esophageal squamous cell carcinoma: A report of 1077 cases. Radiother Oncol. 95:229–233. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Chen J, Liu S, Pan J, Zheng X, Zhu K, Zhu J, Xiao J and Ying M: The pattern and prevalence of lymphatic spread in thoracic oesophageal squamous cell carcinoma. Eur J Cardiothorac Surg. 36:480–486. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang N, Gu M, Wang J and Wu S: Comparison of nodal irradiation dose using radiotherapy for patients with thoracic esophageal cancer. Oncol Lett 19: 1042-1050, 2020.
APA
Zhang, N., Gu, M., Wang, J., & Wu, S. (2020). Comparison of nodal irradiation dose using radiotherapy for patients with thoracic esophageal cancer. Oncology Letters, 19, 1042-1050. https://doi.org/10.3892/ol.2019.11178
MLA
Zhang, N., Gu, M., Wang, J., Wu, S."Comparison of nodal irradiation dose using radiotherapy for patients with thoracic esophageal cancer". Oncology Letters 19.1 (2020): 1042-1050.
Chicago
Zhang, N., Gu, M., Wang, J., Wu, S."Comparison of nodal irradiation dose using radiotherapy for patients with thoracic esophageal cancer". Oncology Letters 19, no. 1 (2020): 1042-1050. https://doi.org/10.3892/ol.2019.11178
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang N, Gu M, Wang J and Wu S: Comparison of nodal irradiation dose using radiotherapy for patients with thoracic esophageal cancer. Oncol Lett 19: 1042-1050, 2020.
APA
Zhang, N., Gu, M., Wang, J., & Wu, S. (2020). Comparison of nodal irradiation dose using radiotherapy for patients with thoracic esophageal cancer. Oncology Letters, 19, 1042-1050. https://doi.org/10.3892/ol.2019.11178
MLA
Zhang, N., Gu, M., Wang, J., Wu, S."Comparison of nodal irradiation dose using radiotherapy for patients with thoracic esophageal cancer". Oncology Letters 19.1 (2020): 1042-1050.
Chicago
Zhang, N., Gu, M., Wang, J., Wu, S."Comparison of nodal irradiation dose using radiotherapy for patients with thoracic esophageal cancer". Oncology Letters 19, no. 1 (2020): 1042-1050. https://doi.org/10.3892/ol.2019.11178
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team