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Article Open Access

FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma

  • Authors:
    • Yan Wang
    • Mengjing Sun
    • Jibin Liu
    • Ying Liu
    • Chunyi Jiang
    • Huijun Zhu
    • Wei Wang
    • Yao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Clinical Biobank, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Tumor Biobank, Nantong Tumor Hospital, Nantong, Jiangsu 226361, P.R. China, Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 795-804
    |
    Published online on: December 4, 2019
       https://doi.org/10.3892/ol.2019.11183
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Abstract

Fibrinogen C domain‑containing 1 (FIBCD1) is an acetyl‑recognition receptor that affects the occurrence and development of certain tumors. However, the prognostic significance of FIBCD1 in hepatocellular carcinoma (HCC) remains unclear. This study aimed to explore FIBCD1 expression in HCC and to determine the prognostic value of FIBCD1 in patients with HCC. A total of 1,058 liver tissue samples with detailed and complete clinical information were collected, including 495 HCC samples. Tissue microarray immunohistochemistry analysis was used to evaluate FIBCD1 protein expression in the collected tissues. The Kaplan‑Meier plotter online tool was used to investigate the association between FIBCD1 expression and prognosis of patients with HCC. Oncomine and the Gene Expression Profiling Interactive Analysis database were used for bioinformatics analysis of FIBCD1. Results showed that FIBCD1 expression was higher in HCC and was associated with tumor diameter (P=0.002), tumor number (P=0.001), tumor node metastasis stage (P<0.001), primary tumor (T; P<0.001), lymph node metastases (N; P=0.002), distant metastases (M; P=0.023), differentiation degree (P=0.003), vascular invasion (P<0.001) and liver cirrhosis (P=0.011). Patients with HCC and high FIBCD1 expression had worse overall survival than those with low FIBCD1 expression. High FIBCD1 expression (P<0.001), TNM stage (P=0.003), T (P<0.001), N (P=0.014), and vascular invasion (P<0.001) were independent prognostic factors in HCC. Hence, FIBCD1 may be a novel biomarker for prognosis evaluation of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Sun M, Liu J, Liu Y, Jiang C, Zhu H, Wang W and Wang Y: FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma. Oncol Lett 19: 795-804, 2020.
APA
Wang, Y., Sun, M., Liu, J., Liu, Y., Jiang, C., Zhu, H. ... Wang, Y. (2020). FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma. Oncology Letters, 19, 795-804. https://doi.org/10.3892/ol.2019.11183
MLA
Wang, Y., Sun, M., Liu, J., Liu, Y., Jiang, C., Zhu, H., Wang, W., Wang, Y."FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 19.1 (2020): 795-804.
Chicago
Wang, Y., Sun, M., Liu, J., Liu, Y., Jiang, C., Zhu, H., Wang, W., Wang, Y."FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 19, no. 1 (2020): 795-804. https://doi.org/10.3892/ol.2019.11183
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Sun M, Liu J, Liu Y, Jiang C, Zhu H, Wang W and Wang Y: FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma. Oncol Lett 19: 795-804, 2020.
APA
Wang, Y., Sun, M., Liu, J., Liu, Y., Jiang, C., Zhu, H. ... Wang, Y. (2020). FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma. Oncology Letters, 19, 795-804. https://doi.org/10.3892/ol.2019.11183
MLA
Wang, Y., Sun, M., Liu, J., Liu, Y., Jiang, C., Zhu, H., Wang, W., Wang, Y."FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 19.1 (2020): 795-804.
Chicago
Wang, Y., Sun, M., Liu, J., Liu, Y., Jiang, C., Zhu, H., Wang, W., Wang, Y."FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 19, no. 1 (2020): 795-804. https://doi.org/10.3892/ol.2019.11183
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