Oncol Lett 18: [Related article:] 4583-4592, 2019; DOI:
10.3892/ol.2019.10806
Subsequently to the publication of the above paper,
the authors have realized that the Abstract of their article
contained a few errors that were not picked up upon during the
pre-press stages. First, on p. 4583, line 7, the sentence that
starts on this line erroneously referred to the radio-sensitive
sensitive cell line, H128; this sentence should have read as
follows: “The results demonstrated that peptidyl-prolyl cis-trans
isomerase A pseudogene 43 (PPIAP43) transcription was increased
2-fold in cells irradiated with 2 Gy gamma radiation compared with
unirradiated cells in pre-reported radio-sensitive sensitive cell
lines H69, H146, H209 and H187. Secondly, the following sentence
(“These cells shared 259 upregulated and 96 downregulated RNA
transcripts following radiation.”) should not have been included in
the Abstract. Lastly, further changes should have been made to the
subsequent sentence regarding the cell lines described and the
general sentence construction.
Taken in its entirety, the Abstract should have
appeared as follows (the pair of sentences containing changes are
highlighted in bold):
Abstract. Small cell lung cancer (SCLC) is a
highly lethal disease. Although radiation therapy is effective for
the majority of patients with SCLC, patient sensitivity to
radiation varies. The lack of biomarkers impedes advances in
targeting radiation-sensitive patients. In the present study, the
changes in transcription patterns of SCLC cell lines were evaluated
with or without 2 Gy gamma radiation. The results demonstrated
that peptidyl-prolyl cis-trans isomerase A pseudogene 43 (PPIAP43)
transcription was increased 2-fold in cells irradiated with 2 Gy
gamma radiation compared with unirradiated cells in pre-reported
radio-sensitive sensitive cell lines H69, H146, H209 and H187.
PPIAP43 was not upregulated 2-fold following irradiation with 2 Gy
gamma radiation compared with unirradiated cells in the
pre-reported, less sensitive cell lines H526 and D153. The RNA
transcript of PPIAP43 was aligned with the mRNA of peptidyl-prolyl
cis-trans isomerase A (PPIA) at 2 sections (3,732 to 3,917 and
5,327 to 5,657 of the PPIA gene) and the sequences were shown to be
96 and 94% similar, respectively. Therefore, PPIAP43 may act as a
sponge for microRNAs which bind with the RNA of PPIA. Therefore,
PPIAP43 RNA transcription may serve as a potential biomarker of
radio-sensitivity of SCLC.
The authors regret that these errors were not
identified prior to the publication of this paper, and apologize to
the readers for any confusion or inconvenience caused.
