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Identification of B‑cell translocation gene 1‑controlled gene networks in diffuse large B‑cell lymphoma: A study based on bioinformatics analysis

  • Authors:
    • Wei Yan
    • Shawn Xiang Li
    • Hongyu Gao
    • Wei Yang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, P.R. China, International College, China Medical University, Shenyang, Liaoning 110022, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2825-2835
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    Published online on: January 8, 2019
       https://doi.org/10.3892/ol.2019.9900
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Abstract

B‑cell translocation gene 1 (BTG1) is a member of the BTG/transducer of Erb family. The present study evaluated the impact of BTG1 gene expression on the clinical outcome of diffuse large B‑cell lymphoma (DLBCL) and investigated potential mechanisms using the Gene Expression Omnibus (GEO) database. The gene expression profile datasets GSE31312, GSE10846, GSE65420 and GSE87371 were downloaded from the GEO database. BTG1 expression and clinicopathological data were obtained from the GSE31312 dataset. In 498 cases, the expression of BTG1 in DLBCL was associated with treatment response (χ2=19.020; P<0.001) and International Prognostic Index score (χ2=5.320; P=0.025). Using the Kaplan‑Meier method, it was identified that the expression of BTG1 was associated with overall survival (OS) and progression‑free survival (PFS) times. Univariate and multivariate Cox regression analysis demonstrated that BTG1 was an independent predictive factor for OS and PFS. From the overlapping analysis of 407 BTG1‑associated genes and 22,187 DLBCL‑associated genes, 401 genes were identified as BTG1‑associated DLBCL genes. Pathway analysis revealed that BTG1‑associated DLBCL genes were associated with cancer progression and DLBCL signaling pathways. Subsequently, a protein‑protein interaction network was constructed of the BTG1‑associated genes, which consisted of 235 genes and 601 interactions. Additionally, 24 genes with high degrees in the network were identified as hub genes, which included genes associated with ‘ribosome’ [ribosomal protein (RP) L11, RPL3, RPS29, RPL19, RPL15 and RPL12], ‘cell cycle’ (ubiquitin carboxyl extension protein 52, ATM and Ras homolog family member H), ‘mitogen‑activated protein kinase pathway’ (mitogen‑activated protein kinase 1), ‘histone modification’ (ASH1‑like protein) and ‘transcription/translation’ (eukaryotic translation initiation factor 3 subunit E, eukaryotic translation elongation factor 1 δ, transcription termination factor 1, cAMP responsive element binding protein 1 and RNA polymerase II subunit F). In conclusion, BTG1 may serve as a predictive biomarker for DLBCL prognosis. Additionally, bioinformatics analysis indicated that BTG1 may exhibit key functions in the progression and development of DLBCL.
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Copy and paste a formatted citation
Spandidos Publications style
Yan W, Li SX, Gao H and Yang W: Identification of B‑cell translocation gene 1‑controlled gene networks in diffuse large B‑cell lymphoma: A study based on bioinformatics analysis. Oncol Lett 17: 2825-2835, 2019.
APA
Yan, W., Li, S.X., Gao, H., & Yang, W. (2019). Identification of B‑cell translocation gene 1‑controlled gene networks in diffuse large B‑cell lymphoma: A study based on bioinformatics analysis. Oncology Letters, 17, 2825-2835. https://doi.org/10.3892/ol.2019.9900
MLA
Yan, W., Li, S. X., Gao, H., Yang, W."Identification of B‑cell translocation gene 1‑controlled gene networks in diffuse large B‑cell lymphoma: A study based on bioinformatics analysis". Oncology Letters 17.3 (2019): 2825-2835.
Chicago
Yan, W., Li, S. X., Gao, H., Yang, W."Identification of B‑cell translocation gene 1‑controlled gene networks in diffuse large B‑cell lymphoma: A study based on bioinformatics analysis". Oncology Letters 17, no. 3 (2019): 2825-2835. https://doi.org/10.3892/ol.2019.9900
Copy and paste a formatted citation
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Spandidos Publications style
Yan W, Li SX, Gao H and Yang W: Identification of B‑cell translocation gene 1‑controlled gene networks in diffuse large B‑cell lymphoma: A study based on bioinformatics analysis. Oncol Lett 17: 2825-2835, 2019.
APA
Yan, W., Li, S.X., Gao, H., & Yang, W. (2019). Identification of B‑cell translocation gene 1‑controlled gene networks in diffuse large B‑cell lymphoma: A study based on bioinformatics analysis. Oncology Letters, 17, 2825-2835. https://doi.org/10.3892/ol.2019.9900
MLA
Yan, W., Li, S. X., Gao, H., Yang, W."Identification of B‑cell translocation gene 1‑controlled gene networks in diffuse large B‑cell lymphoma: A study based on bioinformatics analysis". Oncology Letters 17.3 (2019): 2825-2835.
Chicago
Yan, W., Li, S. X., Gao, H., Yang, W."Identification of B‑cell translocation gene 1‑controlled gene networks in diffuse large B‑cell lymphoma: A study based on bioinformatics analysis". Oncology Letters 17, no. 3 (2019): 2825-2835. https://doi.org/10.3892/ol.2019.9900
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