Open Access

Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang

  • Authors:
    • Liyun Cheng
    • Guijun Shi
    • Chunxiao Fang
    • Guanghua Li
    • Yong Zheng
    • Weigang Chen
  • View Affiliations

  • Published online on: January 8, 2019     https://doi.org/10.3892/ol.2019.9904
  • Pages: 2657-2668
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite improvements in diagnosis and treatment, the survival of patients with advanced stages of esophageal squamous cell carcinoma (ESCC) remains poor. Therefore, novel biomarkers that can assist with early detection of ESCC are required. In the present study, three paired ESCC and normal esophageal tissue samples from Xinjiang Kazakh patients were obtained and microRNA (miRNA) microarray analysis was used to detect the differentially‑expressed miRNAs. The target genes of the identified miRNAs were predicted using miRWalk software. A total of 23 miRNAs were differently expressed in Kazakh patients with ESCC. Gene Ontology enrichment analysis demonstrated that the upregulated miRNAs were predominantly associated with the ‘vesicle’ and ‘membrane‑bounded vesicle’ terms, while the downregulated miRNAs were primarily associated with the term ‘negative regulation of integrin‑mediated signaling pathway’. The most highly enriched Kyoto Encyclopedia of Genes and Genomes pathway for the differentially‑expressed miRNAs was ‘Endocrine and other factor‑regulated calcium reabsorption’. Protein‑protein interaction network analysis revealed that IQ motif containing GTPase activating protein 1, RAB11A, lysine acetyltransferase 2B, catenin α 1 and tight junction protein 2 were hub genes of the network. In conclusion, a number of differentially‑expressed miRNAs were identified in ESCC tissues samples from Xinjiang Kazakh patients, which may improve the understanding of the processes of tumorigenesis and development.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Cheng L, Shi G, Fang C, Li G, Zheng Y and Chen W: Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang. Oncol Lett 17: 2657-2668, 2019
APA
Cheng, L., Shi, G., Fang, C., Li, G., Zheng, Y., & Chen, W. (2019). Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang. Oncology Letters, 17, 2657-2668. https://doi.org/10.3892/ol.2019.9904
MLA
Cheng, L., Shi, G., Fang, C., Li, G., Zheng, Y., Chen, W."Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang". Oncology Letters 17.3 (2019): 2657-2668.
Chicago
Cheng, L., Shi, G., Fang, C., Li, G., Zheng, Y., Chen, W."Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang". Oncology Letters 17, no. 3 (2019): 2657-2668. https://doi.org/10.3892/ol.2019.9904