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Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang

  • Authors:
    • Liyun Cheng
    • Guijun Shi
    • Chunxiao Fang
    • Guanghua Li
    • Yong Zheng
    • Weigang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Digestion, The First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2657-2668
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    Published online on: January 8, 2019
       https://doi.org/10.3892/ol.2019.9904
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Abstract

Despite improvements in diagnosis and treatment, the survival of patients with advanced stages of esophageal squamous cell carcinoma (ESCC) remains poor. Therefore, novel biomarkers that can assist with early detection of ESCC are required. In the present study, three paired ESCC and normal esophageal tissue samples from Xinjiang Kazakh patients were obtained and microRNA (miRNA) microarray analysis was used to detect the differentially‑expressed miRNAs. The target genes of the identified miRNAs were predicted using miRWalk software. A total of 23 miRNAs were differently expressed in Kazakh patients with ESCC. Gene Ontology enrichment analysis demonstrated that the upregulated miRNAs were predominantly associated with the ‘vesicle’ and ‘membrane‑bounded vesicle’ terms, while the downregulated miRNAs were primarily associated with the term ‘negative regulation of integrin‑mediated signaling pathway’. The most highly enriched Kyoto Encyclopedia of Genes and Genomes pathway for the differentially‑expressed miRNAs was ‘Endocrine and other factor‑regulated calcium reabsorption’. Protein‑protein interaction network analysis revealed that IQ motif containing GTPase activating protein 1, RAB11A, lysine acetyltransferase 2B, catenin α 1 and tight junction protein 2 were hub genes of the network. In conclusion, a number of differentially‑expressed miRNAs were identified in ESCC tissues samples from Xinjiang Kazakh patients, which may improve the understanding of the processes of tumorigenesis and development.
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View References

1 

Li C, Xia G, Jianqing Z, Mei Y, Ge B and Li Z: Serum differential protein identification of Xinjiang Kazakh esophageal cancer patients based on the two-dimensional liquid-phase chromatography and LTQ MS. Mol Biol Rep. 41:2893–2905. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Wang J, Jia Y, Wang N, Zhang X, Tan B, Zhang G and Cheng Y: The clinical significance of tumor-infiltrating neutrophils and neutrophil-to-CD8+ lymphocyte ratio in patients with resectable esophageal squamous cell carcinoma. J Transl Med. 12:72014. View Article : Google Scholar : PubMed/NCBI

4 

Zeng H, Zheng R, Guo Y, Zhang S, Zou X, Wang N, Zhang L, Tang J, Chen J, Wei K, et al: Cancer survival in China, 2003–2005: A population-based study. Int J Cancer. 136:1921–1930. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Zhang Y: Distribution of Esophageal Cancer in Xinjiang. J Xinjiang Med Univ. 11:139–145. 1988.(In Chinese).

6 

Wang XM, Jie ES and Yan-Qing MA: Case-control study on risk factors of esophageal cancer in Xinjiang Kazakh nationality. Chinese J Public Health. 23:737–738. 2007.(In Chinese).

7 

Kozomara A and Griffithsjones S: miRBase: Annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 42:D68–D73. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Baek D, Villén J, Shin C, Camargo FD, Gygi SP and Bartel DP: The impact of microRNAs on protein output. Nature. 455:64–71. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Harada K, Baba Y, Ishimoto T, Shigaki H, Kosumi K, Yoshida N, Watanabe M and Baba H: The role of microRNA in esophageal squamous cell carcinoma. J Gastroenterol. 51:520–530. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Laganà A, Russo F, Sismeiro C, Giugno R, Pulvirenti A and Ferro A: Variability in the incidence of miRNAs and genes in fragile sites and the role of repeats and CpG islands in the distribution of genetic material. PLoS One. 5:e111662010. View Article : Google Scholar : PubMed/NCBI

11 

Friedman JM and Jones PA: MicroRNAs: Critical mediators of differentiation, development and disease. Swiss Med Wkly. 139:466–472. 2009.PubMed/NCBI

12 

Gao W, Shen H, Liu L, Xu J, Xu J and Shu Y: MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis. J Cancer Res Clin Oncol. 137:557–566. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Hu JM, Chang AM, Chen YZ, Yuan XL and Li F: Regulatory Role of miR-203 in occurrence and progression of kazakh esophageal squamous cell carcinoma. Sci Rep. 6:237802016. View Article : Google Scholar : PubMed/NCBI

14 

Song X, You W, Zhu J, Cui X, Hu J, Chen Y, Liu W, Wang L, Li S, Wei Y, et al: A genetic variant in miRNA-219-1 is associated with risk of esophageal squamous cell carcinoma in chinese kazakhs. Dis Markers. 2015:5415312015. View Article : Google Scholar : PubMed/NCBI

15 

Yamasaki M, Miyata H, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M and Doki Y: Evaluation of the nodal status in the 7th edition of the UICC-TNM classification for esophageal squamous cell carcinoma: Proposed modifications for improved survival stratification: Impact of lymph node metastases on overall survival after esophagectomy. Ann Surg Oncol. 21:2850–2856. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Zhao T and Liu H: ‘Sparse Additive Machine’, International Conference on Artificial Intelligence and Statistics. 2012.

17 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Domper Arnal MJ, Ferrandez Arenas A and Lanas Arbeloa A: Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries. World J Gastroenterol. 21:7933–7943. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Guo Y, Chen Z, Zhang L, Zhou F, Shi S, Feng X, Li B, Meng X, Ma X, Luo M, et al: Distinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma. Cancer Res. 68:26–33. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, et al: MicroRNA expression profiles classify human cancers. Nature. 435:834–838. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Yang L, Ji Y, Chen L, Li M, Wu F, Hu J, Jiang J, Cui X, Chen Y, Pang L, et al: Genetic variability in LMP2 and LMP7 is associated with the risk of esophageal squamous cell carcinoma in the Kazakh population but is not associated with HPV infection. PLoS One. 12:e01863192017. View Article : Google Scholar : PubMed/NCBI

23 

Zhou YX, Zhou KM, Liu Q, Wang H, Wang W, Shi Y and Ma YQ: The effect of Glut1 and c-myc on prognosis in esophageal squamous cell carcinoma of Kazakh and Han patients. Future Oncol. 14:1801–1815. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Li J, Li X, Li Y, Yang H, Wang L, Qin Y, Liu H, Fu L and Guan XY: Cell-specific detection of mir-375 downregulation for predicting the prognosis of esophageal squamous cell carcinoma by miRNA in situ hybridization. PLoS One. 8:e535822013. View Article : Google Scholar : PubMed/NCBI

25 

Huang G: Erratum: Differential expression of miR-21 and miR-75 in esophageal carcinoma patients and its clinical implication. Am J Transl Res. 9:19612017.PubMed/NCBI

26 

Wang C, Guan S, Chen X, Liu B, Liu F, Han L, Un Nesa E, Song Q, Bao C, Wang X and Cheng Y: Clinical potential of miR-3651 as a novel prognostic biomarker for esophageal squamous cell cancer. Biochem Biophys Res Commun. 465:30–34. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Tian L, Li M, Ge J, Guo Y, Sun Y, Liu M and Xiao H: MiR-203 is downregulated in laryngeal squamous cell carcinoma and can suppress proliferation and induce apoptosis of tumours. Tumour Biol. 35:5953–5963. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Liu Y, Ren F, Rong M, Luo Y, Dang Y and Chen G: Association between underexpression of microrna-203 and clinicopathological significance in hepatocellular carcinoma tissues. Cancer Cell Int. 15:622015. View Article : Google Scholar : PubMed/NCBI

29 

Mao L, Zhang Y, Mo W, Yu Y and Lu H: BANF1 is downregulated by IRF1-regulated microRNA-203 in cervical cancer. PLoS One. 10:e01170352015. View Article : Google Scholar : PubMed/NCBI

30 

Wang N, Liang H, Zhou Y, Wang C, Zhang S, Pan Y, Wang Y, Yan X, Zhang J, Zhang CY, et al: miR-203 suppresses the proliferation and migration and promotes the apoptosis of lung cancer cells by targeting SRC. PLoS One. 9:e1055702014. View Article : Google Scholar : PubMed/NCBI

31 

Li Y, Tan W, Neo TW, Aung MO, Wasser S, Lim SG and Tan TM: Role of the miR-106b-25microRNA cluster in hepatocellular carcinoma. Cancer Sci. 100:1234–1242. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Yang M, Liu R, Sheng J, Liao J, Wang Y, Pan E, Guo W, Pu Y and Yin L: Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma. Oncol Rep. 29:169–176. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Liu T, Liu Q, Zheng S, Gao X, Lu M, Yang C, Dai F, Sheyhidin I and Lu X: MicroRNA-21 promotes cell growth and migration by targeting programmed cell death 4 gene in Kazakh's esophageal squamous cell carcinoma. Dis Markers. 2014:2328372014. View Article : Google Scholar : PubMed/NCBI

34 

Savita U and Karunagaran D: MicroRNA-106b-25 cluster targets β-TRCP2, increases the expression of Snail and enhances cell migration and invasion in H1299 (non small cell lung cancer) cells. Biochem Biophys Res Commun. 434:841–847. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Li BS, Zuo QF, Zhao YL, Xiao B, Zhuang Y, Mao XH, Wu C, Yang SM, Zeng H, Zou QM and Guo G: MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival. Oncogene. 34:2556–2565. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Zhao Z, Liu J, Wang C, Wang Y, Jiang Y and Guo M: MicroRNA-25 regulates small cell lung cancer cell development and cell cycle through cyclin E2. Int J Clin Exp Pathol. 7:7726–7234. 2014.PubMed/NCBI

37 

Qu J, Li M, Zhong W and Hu C: Prognostic role of microRNA-25 in cancers: Evidence from a meta-analysis. Int J Clin Exp Med. 8:12921–12927. 2015.PubMed/NCBI

38 

Xu X, Chen Z, Zhao X, Wang J, Ding D, Wang Z, Tan F, Tan X, Zhou F, Sun J, et al: MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 421:640–645. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Qian J, Li R, Wang YY, Shi Y, Luan WK, Tao T, Zhang JX, Xu YC and You YP: MiR-1224-5p acts as a tumor suppressor by targeting CREB1 in malignant gliomas. Mol Cell Biochem. 403:33–41. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Huang H, Jiang Y, Wang Y, Chen T, Yang L, He H, Lin Z, Liu T, Yang T, Kamp DW, Wu B and Liu G: miR-5100 promotes tumor growth in lung cancer by targeting Rab6. Cancer Lett. 362:15–24. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Matamala N, Vargas MT, Gonzalez-Campora R, Miñambres R, Arias JI, Menéndez P, Andrés-León E, Gómez-López G, Yanowsky K, Calvete-Candenas J, et al: Tumor MicroRNA expression profiling identifies circulating MicroRNAs for early breast cancer detection. Clin Chem. 61:1098–1106. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Song W, Tang L, Xu Y, Xu J, Zhang W, Xie H, Wang S and Guan X: Corrigendum: PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer. Sci Rep. 7:443462017. View Article : Google Scholar : PubMed/NCBI

43 

Zha R, Guo W, Zhang Z, Qiu Z, Wang Q, Ding J, Huang S, Chen T, Gu J, Yao M and He X: Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin β1 in hepatocellular carcinoma. PLoS One. 9:e876652014. View Article : Google Scholar : PubMed/NCBI

44 

Zang W, Wang Y, Du Y, Xuan X, Wang T, Li M, Ma Y, Li P, Chen X, Dong Z and Zhao G: Differential expression profiling of microRNAs and their potential involvement in esophageal squamous cell carcinoma. Tumour Biol. 35:3295–3304. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Hakomori S: Aberrant glycosylation in cancer cell membranes as focused on glycolipids: Overview and perspectives. Cancer Res. 45:2405–2414. 1985.PubMed/NCBI

46 

Alikhani N, Ferguson RD, Novosyadlyy R, Gallagher EJ, Scheinman EJ, Yakar S and LeRoith D: Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model. Oncogene. 32:961–967. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Berridge MJ, Lipp P and Bootman MD: The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol. 1:11–21. 2000. View Article : Google Scholar : PubMed/NCBI

48 

Zhao P, Xiao L, Peng J, Qian YQ and and Huang CC: Exosomes derived from bone marrow mesenchymal stem cells improve osteoporosis through promoting osteoblast proliferation via MAPK pathway. Eur Rev Med Pharmacol Sci. 22:3962–3970. 2018.PubMed/NCBI

49 

Weyant MJ, Carothers AM, Bertagnolli ME and Bertagnolli MM: Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways. Clin Cancer Res. 6:949–956. 2000.PubMed/NCBI

50 

Choi S and Anderson RA: IQGAP1 is a phosphoinositide effector and kinase scaffold. Adv Biol Regul. 60:29–35. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Wang XX, Wang K, Li XZ, Zhai LQ, Qu CX, Zhao Y, Liu ZR, Wang HZ, An QJ, Jing LW and Wang XH: Targeted knockdown of IQGAP1 inhibits the progression of esophageal squamous cell carcinoma in vitro and in vivo. PLoS One. 9:e965012014. View Article : Google Scholar : PubMed/NCBI

52 

Xu CQ, Zhu ST, Wang M, Guo SL, Sun XJ, Cheng R, Xing J, Wang WH, Shao LL and Zhang ST: Pathway analysis of differentially expressed genes in human esophageal squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 19:1652–1661. 2015.PubMed/NCBI

53 

Vij M, Shanmugam NP, Reddy MS, Sankaranarayanan S and Rela M: Paediatric hepatocellular carcinoma in tight junction protein 2 (TJP2) deficiency. Virchows Arch. 471:679–683. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Ganguly P and Ganguly N: Transcriptomic analyses of genes differentially expressed by high-risk and low-risk human papilloma virus E6 oncoproteins. Virusdisease. 26:105–116. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Zhang G, Zhang W, Li B, Stringer-Reasor E, Chu C, Sun L, Bae S, Chen D, Wei S, Jiao K, et al: MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer. Breast Cancer Res. 19:732017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cheng L, Shi G, Fang C, Li G, Zheng Y and Chen W: Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang. Oncol Lett 17: 2657-2668, 2019.
APA
Cheng, L., Shi, G., Fang, C., Li, G., Zheng, Y., & Chen, W. (2019). Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang. Oncology Letters, 17, 2657-2668. https://doi.org/10.3892/ol.2019.9904
MLA
Cheng, L., Shi, G., Fang, C., Li, G., Zheng, Y., Chen, W."Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang". Oncology Letters 17.3 (2019): 2657-2668.
Chicago
Cheng, L., Shi, G., Fang, C., Li, G., Zheng, Y., Chen, W."Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang". Oncology Letters 17, no. 3 (2019): 2657-2668. https://doi.org/10.3892/ol.2019.9904
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng L, Shi G, Fang C, Li G, Zheng Y and Chen W: Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang. Oncol Lett 17: 2657-2668, 2019.
APA
Cheng, L., Shi, G., Fang, C., Li, G., Zheng, Y., & Chen, W. (2019). Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang. Oncology Letters, 17, 2657-2668. https://doi.org/10.3892/ol.2019.9904
MLA
Cheng, L., Shi, G., Fang, C., Li, G., Zheng, Y., Chen, W."Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang". Oncology Letters 17.3 (2019): 2657-2668.
Chicago
Cheng, L., Shi, G., Fang, C., Li, G., Zheng, Y., Chen, W."Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang". Oncology Letters 17, no. 3 (2019): 2657-2668. https://doi.org/10.3892/ol.2019.9904
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