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Review

A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene‑expressing stem cells to selectively target choriocarcinoma (Review)

  • Authors:
    • Gyu‑Sik Kim
    • Kyung‑A Hwang
    • Kyung‑Chul Choi
  • View Affiliations / Copyright

    Affiliations: Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, North Chungcheong 28644, Republic of Korea
  • Pages: 2576-2582
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    Published online on: January 9, 2019
       https://doi.org/10.3892/ol.2019.9911
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Abstract

Gestational trophoblastic disease (GTD) is an unusual disease occurring in pregnancy that originates from abnormal trophoblastic cells and comprises a group of diseases with different properties of invasion, metastasis and recurrence. The GTD group includes hydatidiform moles and gestational trophoblastic neoplasms (GTNs), with GTNs being divided into invasive moles, choriocarcinoma, placental site trophoblastic tumors and epithelioid trophoblastic tumors. The present review focuses on current effective treatments for GTD, including conventional and novel promising direct enzyme prodrug therapies (DEPTs). Conventional therapies, such as chemotherapy and hysterectomy, are currently used in a clinical setting; however, the use of diverse DEPTs, including antibody‑DEPT and gene‑DEPT is also being attempted to cure GTNs. In addition, gene delivery tools using genetically engineered neural stem cells (NSCs) are presently being examined for the treatment of GTNs. The tumor‑tropism of NSCs by chemoattractant factors is a unique characteristic of these cells and can serve as a vehicle to deliver anticancer agents. Previous studies have demonstrated that injection with NSC‑expressing suicide genes into xenograft animal models has a significant inhibitory effect on tumor growth. Stem cells can be genetically engineered to express anticancer genes, which migrate to the metastatic sites and selectively target cancer cells, and are considered to effectively target metastatic GTNs. However, the safety issue of stem cell therapy, such as tumorigenesis, remains a challenge. Novel therapies comprising a combination of conventional and novel promising treatments are anticipated to be definitive treatments for metastasized and/or recurrent patients with GTNs.
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Copy and paste a formatted citation
Spandidos Publications style
Kim GS, Hwang KA and Choi KC: A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene‑expressing stem cells to selectively target choriocarcinoma (Review). Oncol Lett 17: 2576-2582, 2019.
APA
Kim, G., Hwang, K., & Choi, K. (2019). A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene‑expressing stem cells to selectively target choriocarcinoma (Review). Oncology Letters, 17, 2576-2582. https://doi.org/10.3892/ol.2019.9911
MLA
Kim, G., Hwang, K., Choi, K."A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene‑expressing stem cells to selectively target choriocarcinoma (Review)". Oncology Letters 17.3 (2019): 2576-2582.
Chicago
Kim, G., Hwang, K., Choi, K."A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene‑expressing stem cells to selectively target choriocarcinoma (Review)". Oncology Letters 17, no. 3 (2019): 2576-2582. https://doi.org/10.3892/ol.2019.9911
Copy and paste a formatted citation
x
Spandidos Publications style
Kim GS, Hwang KA and Choi KC: A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene‑expressing stem cells to selectively target choriocarcinoma (Review). Oncol Lett 17: 2576-2582, 2019.
APA
Kim, G., Hwang, K., & Choi, K. (2019). A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene‑expressing stem cells to selectively target choriocarcinoma (Review). Oncology Letters, 17, 2576-2582. https://doi.org/10.3892/ol.2019.9911
MLA
Kim, G., Hwang, K., Choi, K."A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene‑expressing stem cells to selectively target choriocarcinoma (Review)". Oncology Letters 17.3 (2019): 2576-2582.
Chicago
Kim, G., Hwang, K., Choi, K."A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene‑expressing stem cells to selectively target choriocarcinoma (Review)". Oncology Letters 17, no. 3 (2019): 2576-2582. https://doi.org/10.3892/ol.2019.9911
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