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E‑cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases

  • Authors:
    • Petra Jurčić
    • Petra Radulović
    • Melita Perić Balja
    • Milan Milošević
    • Božo Krušlin
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    Affiliations: Department of Radiotherapy and Medical Oncology, University Hospital for Tumors, Clinical Hospital Center Sestre Milosrdnice, Zagreb 10000, Croatia, Ljudevit Jurak Department of Pathology and Cytology, University Hospital for Tumors, Clinical Hospital Center Sestre Milosrdnice, Zagreb 10000, Croatia, Department of Oncological Pathology, University Hospital for Tumors, Clinical Hospital Center Sestre Milosrdnice, Zagreb 10000, Croatia, Department for Environmental and Occupational Health, University of Zagreb, School of Medicine, Andrija Štampar School of Public Health, Zagreb 10000, Croatia
    Copyright: © Jurčić et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2881-2889
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    Published online on: January 10, 2019
       https://doi.org/10.3892/ol.2019.9917
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Abstract

In Croatia, colorectal cancer mortality rates in males are the third highest in Europe, after Hungary and Slovakia. The results for females rank Croatia in second place after Hungary. According to previous studies, the loss of E‑cadherin expression and the higher expression of neural precursor cell‑expressed developmentally downregulated 9 (NEDD9) are associated with a worse prognosis. The aim of the present study was to analyze the immunohistochemical expression of NEDD9 and E‑cadherin as markers of metastatic potential using a tissue microarray. This retrospective study included 40 previously untreated patients, including 23 males and 17 females with a median age of 64.5 years (range 38‑84), with colorectal cancer and synchronous liver metastases that underwent simultaneous colorectal and hepatic resection between January 1st 2006 and December 31st 2013, in the Clinical Hospital Center Sestre Milosrdnice (Zagreb, Croatia). The most frequent tumor stage was T3, while the most frequent nodal stage was N1. Microvascular invasion was present in 37.5% of patients, while perineural invasion was observed in 30% of patients. The immunohistochemical staining index of E‑cadherin was highly positive in 87.5% samples of colorectal cancer, 67.7% of lymph nodes and 77.5% of liver metastases. In the primary tumor, highly positive NEDD9 expression was identified in 22.5% of patients. In lymph nodes, it was identified in 35.5% of patients, while in the liver, it was identified in 30% of patients. Significant positive correlations were observed between the percentage of positive lymph nodes and the immunohistochemical staining index of E‑cadherin (ρ=0.372; P=0.039) and NEDD9 (ρ=0.451; P=0.011) in lymph nodes. After the conclusion of the study, 55% of the patients succumbed. No significant differences in survival rates were identified regarding the expression of E‑cadherin and NEDD9 in the primary tumor, metastatic lymph nodes and liver metastases. Due to the small sample size and the negative results obtained, further research is required to implement these parameters as prognostic factors.
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1 

Croatian National Cancer Registry: Cancer incidence in Croatia 2015. Bulletin No. 40. Zagreb, Croatian National Institute of Public Health. 2018.

2 

Balmaňa J, Balanguer F, Cervantes A and Arnold D: Familial risk-colorectal cancer: ESMO clinical practice guidelines. Ann Oncol. 24 (Suppl 6):vi73–vi80. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Tikhmyanova N and Golemis EA: NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation. PLoS One. 6:e221022011. View Article : Google Scholar : PubMed/NCBI

4 

Huntsman DG and Caldas C: Assignment of the E-cadherin gene (CDH1) to chromosome 16q22.1 by radiation hybrid mapping. Cytogenet Cell Genet. 83:82–83. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Fleming TP, Javed Q and Hay M: Epithelial differentiation and intercellular junction formation in the mouse early embryo. Dev Suppl. 105–112. 1992.PubMed/NCBI

6 

Paschos KA, Canovas D and Bird NC: The role of cell adhesion molecules in the progression of colorectal cancer and the development of liver metastasis. Cell Signal. 21:665–674. 2009. View Article : Google Scholar : PubMed/NCBI

7 

El-Bahrawy MA, Poulsom R, Jeffery R, Talbot I and Alison MR: The expression of E-cadherin and catenins in sporadic colorectal carcinoma. Hum Pathol. 32:1216–1224. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Pećina-Slaus N: Tumor suppressor gene E-cadherin and its role in normal and malignant cells. Cancer Cell Int. 3:172003. View Article : Google Scholar : PubMed/NCBI

9 

Tikhmyanova N, Little JL and Golemis EA: CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci. 67:1025–1048. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Kong C, Wang C, Wang L, Ma M, Niu C, Sun X, Du J, Dong Z, Zhu S, Lu J and Huang B: NEDD9 is a positive regulator of epithelial-mesenchymal transition and promotes invasion in aggressive breast cancer. PLoS One. 6:e226662011. View Article : Google Scholar : PubMed/NCBI

11 

Štajduhar E, Sedić M, Leniček T, Radulović P, Kerenji A, Krušlin B, Pavelić K and Kraljević Pavelić A: Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer. Tumor Biol. 35:6425–6434. 2014. View Article : Google Scholar

12 

Zhang SS, Wu LH, Liu Q, Chen KS and Zhang XF: Elevated expression of NEDD9 is associated with metastatic activity in gastric cancer. Onco Targets Ther. 8:633–640. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Chang JX, Gao F, Zhao GQ and Zhang GJ: Expression and clinical significance of NEDD9 in lung tissue. Med Oncol. 29:2654–2660. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, et al: Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell. 125:1269–1281. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Wang H, Mu X, Zhou S, Zhang J, Dai J, Tang L, Xiao L, Duan Z, Jia L and Chen S: NEDD9 overexpression is associated with the progression of and an unfavorable prognosis in epithelial ovarian cancer. Hum Pathol. 45:401–408. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Wang Z, Shen M, Lu P, Li X, Zhu S and Yue S: NEDD9 may regulate hepatocellular carcinoma cell metastasis by promoting epithelial-mesenchymal-transition and stemness via repressing Smad7. Oncotarget. 8:1714–1724. 2017.PubMed/NCBI

17 

Xue YZ, Sheng YY, Liu ZL, Wei ZQ, Cao HY, Wu YM, Lu YF, Yu LH, Li JP and Li ZS: Expression of NEDD9 in pancreatic ductal adenocarcinoma and its clinical significance. Tumour Biol. 34:895–899. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Morimoto K, Tanaka T, Nitta Y, Ohnishi K, Kawashima H and Nakatani T: NEDD9 crucially regulates TGF-β-triggered epithelial-mesenchymal transition and cell invasion in prostate cancer cells: Involvement in cancer progressiveness. Prostate. 74:901–910. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Wang J, Wang S, Luan Y, Zhang W, Sun C, Cheng G, Li K, Xin Q, Lin Z, Qi T and Kong F: Overexpression of NEDD9 in renal cell carcinoma is associated with tumor migration and invasion. Oncol Lett. 14:8021–8027. 2017.PubMed/NCBI

20 

Cui X, Shen K, Xie Z, Liu T and Zhang H: Identification of key genes in colorectal cancer using random walk with restart. Mol Med Rep. 15:867–872. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Hong SM, Li A, Olino K, Wolfgang CL, Herman JM, Schulick RD, Iacobuzio-Donahue C, Hruban RH and Goggins M: Loss of E-cadherin expression and outcome among patients with resectable pancreatic adenocarcinomas. Mod Pathol. 24:1237–1247. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Yun JA, Kim SH, Hong HK, Yun SH, Kim HC, Chun HK, Cho YB and Lee WY: Loss of E-Cadherin expression is associated with a poor prognosis in stage III colorectal cancer. Oncology. 86:318–328. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Dorudi S, Sheffield JP, Poulsom R, Northover JM and Hart IR: E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study. Am J Pathol. 142:981–986. 1993.PubMed/NCBI

24 

Miladi-Abdennadher I, Abdelmaksoud-Dammak R, Ayed-Guerfali DB, Ayadi L, Khabir A, Amouri A, Frikha F, Tahri N, Ellouz S, Frikha M, et al: Expression of COX-2 and E-cadherin in Tunisian patients with colorectal adenocarcinoma. Acta Histochem. 114:577–581. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Palaghia M, Mihai C, Lozneanu L, Ciobanu D, Trofin AM, Rotariu A, Târcoveanu F and Cijevschi Prelipcean C: E-cadherin expression in primary colorectal cancer and metastatic lymph nodes. Rom J Morphol Embryol. 57:205–209. 2016.PubMed/NCBI

26 

Elzagheid A, Buhmeida A, Laato M, El-Faitori O, Syrjänen K, Collan Y and Pyrhönen S: Loss of E-cadherin expression predicts disease recurrence and shorter survival in colorectal carcinoma. APMIS. 120:539–548. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Gu J, Zhu X, Ye Y, Qu J, Huang L, Li R, Yu Y and Leng X: The level of expression of adhesion molecules CD44v6 and E-cadherin in colorectal cancer and analysis of correlates with metastasis. Zhonghua Wai Ke Za Zhi. 37:108–109. 4–1999.(In Chinese). PubMed/NCBI

28 

Elzagheid A, Algars A, Bendardaf R, Lamlum H, Ristamaki R, Collan Y, Syrjanen K and Pyrhonen S: E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome. World J Gastroenterol. 12:4304–4309. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Tóth L, András C, Molnár C, Tanyi M, Csiki Z, Molnár P and Szántó J: Investigation of β-catenin and E-cadherin expression in Dukes B2 stage colorectal cancer with tissue microarray method. Is it a marker of metastatic potential in rectal cancer? Pathol Oncol Res. 18:429–437. 2012.PubMed/NCBI

30 

Khoursheed MA, Mathew TC, Makar RR, Louis S, Asfar SK, Al-Sayer HM, Dashti HM and Al-Bader A: Expression of E-cadherin in human colorectal cancer. Surgeon. 1:86–91. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Roca F, Mauro LV, Morandi A, Bonadeo F, Vaccaro C, Quintana GO, Specterman S, de Kier Joffé EB, Pallotta MG, Puricelli LI and Lastiri J: Prognostic value of E-cadherin, beta-catenin, MMPs (7 and 9), and TIMPs (1 and 2) in patients with colorectal carcinoma. J Surg Oncol. 93:151–160. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Ghadimi BM, Behrens J, Hoffmann I, Haensch W, Birchmeier W and Schlag PM: Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: Implications for cell adhesion and signaling. Eur J Cancer. 35:60–65. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Kwak JM, Min BW, Lee JH, Choi JS, Lee SI, Park SS, Kim J, Um JW, Kim SH and Moon HY: The prognostic significance of E-cadherin and liver intestine-cadherin expression in colorectal cancer. Dis Colon Rectum. 50:1873–1880. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Lugli A, Zlobec I, Minoo P, Baker K, Tornillo L, Terracciano L and Jass JR: Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: A tissue microarray-based analysis. Histopathology. 50:453–464. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Karamitopoulou E, Zlobec I, Patsouris E, Peros G and Lugli A: Loss of E-cadherin independently predicts the lymph node status in colorectal cancer. Pathology. 43:133–137. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Ozgüven BY, Karaçetin D, Kabukçuoğlu F, Taşkin T and Yener Ş: Immunohistochemical study of E-cadherin and β-catenin expression in colorectal carcinomas. Pol J Pathol. 62:19–24. 2011.PubMed/NCBI

37 

Kim SA, Inamura K, Yamauchi M, Nishihara R, Mima K, Sukawa Y, Li T, Yasunari M, Morikawa T, Fitzgerald KC, et al: Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis. Br J Cancer. 114:199–206. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Ikeguchi M, Taniguchi T, Makino M and Kaibara N: Reduced E-cadherin expression and enlargement of cancer nuclei strongly correlate with hematogenic metastasis in colorectal adenocarcinoma. Scand J Gastroenterol. 35:839–846. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Kim JC, Roh SA, Kim HC, Koo KH, Cho YK, Yu CS, Kwon YM and Kim JS: Coexpression of carcinoembryonic antigen and E-cadherin in colorectal adenocarcinoma with liver metastasis. J Gastrointest Surg. 7:931–938. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Mohri Y: Prognostic significance of E-cadherin expression in human colorectal cancer tissue. Surg Today. 27:606–612. 1997. View Article : Google Scholar : PubMed/NCBI

41 

Nanashima A, Yamaguchi H, Sawai T, Yamaguchi E, Kidogawa H, Matsuo S, Yasutake T, Tsuji T, Jibiki M, Nakagoe T and Ayabe H: Prognostic factors in hepatic metastases of colorectal carcinoma: Immunohistochemical analysis of tumor biological factors. Dig Dis Sci. 46:1623–1628. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Kaihara T, Kusaka T, Nishi M, Kawamata H, Imura J, Kitajima K, Itoh-Minami R, Aoyama N, Kasuga M, Oda Y, et al: Dedifferentiation and decreased expression of adhesion molecules, E-cadherin and ZO-1, in colorectal cancer are closely related to liver metastasis. J Exp Clin Cancer Res. 22:117–123. 2003.PubMed/NCBI

43 

Truant SC, Gouyer VP, Leteurtre EA, Zerimech F, Huet GM and Pruvot FR: E-cadherin and beta-catenin mRNA levels throughout colon cancer progression. J Surg Res. 150:212–218. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Gagliardi G, Kandemir O, Liu D, Guida M, Benvestito S, Ruers TG, Benjamin IS, Northover JM, Stamp GW, Talbot IC, et al: Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. Virchows Arch. 426:149–154. 1995. View Article : Google Scholar : PubMed/NCBI

45 

Kang H, Min BS, Lee KY, Kim NK, Kim SN, Choi J and Kim H: Loss of E-cadherin and MUC2 expressions correlated with poor survival in patients with stages II and III colorectal carcinoma. Ann Surg Oncol. 18:711–719. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Lee SJ, Choi SY, Kim WJ, Ji M, Lee TG, Son BR, Yoon SM, Sung R, Lee EJ, Youn SJ and Park SM: Combined aberrant expression of E-cadherin and S100A4, but not β-catenin is associated with disease-free survival and overall survival in colorectal cancer patients. Diagn Pathol. 8:992013. View Article : Google Scholar : PubMed/NCBI

47 

Xia D, Holla VR, Wang D, Menter DG and DuBois RN: HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells. Cancer Res. 70:824–831. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Li P, Zhou H, Zhu X, Ma G, Liu C, Lin B and Mao W: High expression of NEDD9 predicts adverse outcomes of colorectal cancer patients. Int J Clin Exp Pathol. 7:2565–2570. 2014.PubMed/NCBI

49 

Li Y, Bavarva JH, Wang Z, Guo J, Qian C, Thibodeau SN, Golemis EA and Liu W: HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression. Oncogene. 30:2633–2643. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Awasthi S, Maity T, Oyler BL, Qi Y, Zhang X, Goodlett DR and Guha U: Quantitative targeted proteomic analysis of potential markers of tyrosine kinase inhibitor (TKI) sensitivity in EGFR mutated lung adenocarcinoma. J Proteomics. 189:48–59. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Miao Y, Li AL, Wang L, Fan CF, Zhang XP, Xu HT, Yang LH, Liu Y and Wang EH: Overexpression of NEDD9 is associated with altered expression of E-Cadherin, β-Catenin and N-Cadherin and predictive of poor prognosis in non-small cell lung cancer. Pathol Oncol Res. 19:281–286. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Zhang R, Zhang X, Ma B, Xiao B, Huang F, Huang P, Ying C, Liu T and Wang Y: Enhanced antitumor effect of combining TRAIL and MnSOD mediated by CEA-controlled oncolytic adenovirus in lung cancer. Cancer Gene Ther. 23:168–177. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jurčić P, Radulović P, Balja MP, Milošević M and Krušlin B: E‑cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases. Oncol Lett 17: 2881-2889, 2019.
APA
Jurčić, P., Radulović, P., Balja, M.P., Milošević, M., & Krušlin, B. (2019). E‑cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases. Oncology Letters, 17, 2881-2889. https://doi.org/10.3892/ol.2019.9917
MLA
Jurčić, P., Radulović, P., Balja, M. P., Milošević, M., Krušlin, B."E‑cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases". Oncology Letters 17.3 (2019): 2881-2889.
Chicago
Jurčić, P., Radulović, P., Balja, M. P., Milošević, M., Krušlin, B."E‑cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases". Oncology Letters 17, no. 3 (2019): 2881-2889. https://doi.org/10.3892/ol.2019.9917
Copy and paste a formatted citation
x
Spandidos Publications style
Jurčić P, Radulović P, Balja MP, Milošević M and Krušlin B: E‑cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases. Oncol Lett 17: 2881-2889, 2019.
APA
Jurčić, P., Radulović, P., Balja, M.P., Milošević, M., & Krušlin, B. (2019). E‑cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases. Oncology Letters, 17, 2881-2889. https://doi.org/10.3892/ol.2019.9917
MLA
Jurčić, P., Radulović, P., Balja, M. P., Milošević, M., Krušlin, B."E‑cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases". Oncology Letters 17.3 (2019): 2881-2889.
Chicago
Jurčić, P., Radulović, P., Balja, M. P., Milošević, M., Krušlin, B."E‑cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases". Oncology Letters 17, no. 3 (2019): 2881-2889. https://doi.org/10.3892/ol.2019.9917
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