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Endoscopic ultrasonography for pretreatment T‑staging of gastric cancer: An in vitro accuracy and discrepancy analysis

  • Authors:
    • Yan Yan
    • Qi Wu
    • Zi‑Yu Li
    • Zhao‑De Bu
    • Jia‑Fu Ji
  • View Affiliations / Copyright

    Affiliations: Endoscopy Center, Beijing Cancer Hospital, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, P.R. China, Department of Gastrointestinal Surgery, Beijing Cancer Hospital, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2849-2855
    |
    Published online on: January 10, 2019
       https://doi.org/10.3892/ol.2019.9920
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Abstract

In the current era of multi‑disciplinary treatment, precise and detailed diagnosis prior to treatment is crucial for clinical practice. For different lesions that fit different indications, the optimum approach for treatment differs significantly. Thus, the recent 8th American Joint Committee on Cancer classification system has introduced ‘clinical stage’ as a criterion. Endoscopic ultrasonography (EUS) has been the first‑line choice for pretreatment staging; however, there is no standardization of the depth classification nor a standard EUS method. Additionally, the accuracy for this diagnostic test has ranged between <40 and 90% in previous studies. The aim of the present study was to determine the accuracy of EUS, identify the discrepancies between EUS and histological results, and analyze the underlying causes. Between June 2014 and February 2016, EUS was performed on gastric carcinoma specimens from 60 consecutive patients. EUS was performed on the resected specimens following surgery, but prior to fixation in formalin, invasion of the gastric wall was determined and the deepest location was marked with sutures. The ultrasound images were independently interpreted, and the quality of the images was scored by two endoscopists. Subsequently, the ultrasound images were compared with the pathological results of the same section. The overall accuracy of EUS was 75%. For locally advanced gastric cancers, EUS had a relatively high accuracy (33/43, 86%). The EUS results corresponded well with the pathological hematoxylin and eosin staining results, and the deepest points determined by EUS were confirmed by pathology in the majority of cases (85%). In total, 50 and 10 cases were scored as having high/moderate and low quality, associated with accuracies of 86% (43/50) and 20% (2/10), respectively. EUS is valuable for pretreatment T‑staging, particularly for advanced cases. Proximal stomach cancer exhibited a tendency for improved accuracy. Overall, the results of the present study suggest that standardized scanning processes, particularly including all‑encompassing scanning, proper probe‑placement and high image quality, lead to improved accuracy of EUS.
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View References

1 

Brierley JD, Gospodarwicz MK, Wittekind C and Amin MB: TNM classification of maligant tumours, 8th ed. (Oxford). Wiley Blackwell. 2017.

2 

Amin MB, Edge SB, Greene FL, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, Sullivan DC, et al: AJCC cancer staging manual. (8th). (New York). Springer. 2017. View Article : Google Scholar

3 

Smyth EC, Verheij M, Allum W, Cunningham D, Cervantes A and Arnold D; ESMO Guidelines Committee, : Gastric Cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 27 Suppl 5:v38–v49. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Japanese Gastric Cancer Association: Japanese gastric cancer treatment guidelines 2014 (ver. 4). Gastric Cancer. 20:1–19. 2017. View Article : Google Scholar

5 

Heyder N, Kaarmann H and Giedl J: Experimental investigations into the possibility of differentiating early from invasive carcinoma of the stomach by means of ultrasound. Endoscopy. 19:228–232. 1987. View Article : Google Scholar : PubMed/NCBI

6 

Papanikolaou IS, Triantafyllou M, Triantafyllou K and Rösch T: EUS in the management of gastric cancer. Ann Gastroenterol. 24:9–15. 2011.PubMed/NCBI

7 

Kutup A, Vashist YK, Groth S, Vettorazzi E, Yekebas EF, Soehendra N and Izbicki JR: Endoscopic ultrasound staging in gastric cancer: Does it help management decisions in the era of neoadjuvant treatment? Endoscopy. 44:572–576. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Jurgensen C, Brand J, Nothnagel M, Arlt A, Neser F, Habeck JO, Schreiber S, Stölzel U, Zeitz M and Hampe J: Prognostic relevance of gastric cancer staging by endoscopic ultrasound. Surg Endosc. 27:1124–1129. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Lee HH, Lim CH, Park JM, Cho YK, Song KY, Jeon HM and Park CH: Low accuracy of endoscopic ultrasonography for detailed T staging in gastric cancer. World J Surg Oncol. 10:1902012. View Article : Google Scholar : PubMed/NCBI

10 

Yoshinaga S, Oda I, Nonaka S, Kushima R and Saito Y: Endoscopic ultrasound using ultrasound probes for the diagnosis of early esophageal and gastric cancers. World J Gastrointest Endosc. 4:218–226. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Kwee RM and Kwee TC: The accuracy of endoscopic ultrasonography in differentiating mucosal from deeper gastric cancer. Am J Gastroenterol. 103:1801–1809. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Cardoso R, Coburn N, Seevaratnam R, Sutradhar R, Lourenco LG, Mahar A, Law C, Yong E and Tinmouth J: A systematic review and meta-analysis of the utility of EUS for preoperative staging for gastric cancer. Gastric Cancer. 15 Suppl 1:S19–S26. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Puli SR, Batapati Krishna Reddy J, Bechtold ML, Antillon MR and Ibdah JA: How good is endoscopic ultrasound for TNM staging of gastric cancers? A meta-analysis and systematic review. World J Gastroenterol. 14:4011–4019. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Mocellin S, Marchet A and Nitti D: EUS for the staging of gastric cancer: A meta-analysis. Gastrointest Endosc. 73:1122–1134. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Mocellin S and Pasquali S: Diagnostic accuracy of endoscopic ultrasonography (EUS) for the preoperative locoregional staging of primary gastric cancer. Cochrane Database Syst Rev. CD009944. 2015. View Article : Google Scholar

16 

Ajani JA, D'Amico TA, Almhanna K, Bentrem DJ, Chao J, Das P, Denlinger CS, Fanta P, Farjah F, Fuchs CS, et al: Gastric cancer, version 3.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 14:1286–1312. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Yamamoto S, Nishida T, Kato M, Inoue T, Hayashi Y, Kondo J, Akasaka T, Yamada T, Shinzaki S, Iijima H, et al: Evaluation of endoscopic ultrasound image quality is necessary in endosonographic assessment of early gastric cancer invasion depth. Gastroenterol Res Pract. 2012:1945302012. View Article : Google Scholar : PubMed/NCBI

18 

Seevaratnam R, Cardoso R, McGregor C, Lourenco L, Mahar A, Sutradhar R, Law C, Paszat L and Coburn N: How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis. Gastric Cancer. 15 Suppl 1:S3–S18. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Park JS, Kim H, Bang B, Kwon K and Shin Y: Accuracy of endoscopic ultrasonography for diagnosing ulcerative early gastric cancers. Medicine (Baltimore). 95:e39552016. View Article : Google Scholar : PubMed/NCBI

20 

Tsuzuki T, Okada H, Kawahara Y, Nasu J, Takenaka R, Inoue M, Kawano S, Kita M, Hori K and Yamamoto K: Usefulness and problems of endoscopic ultrasonography in prediction of the depth of tumor invasion in early gastric cancer. Acta Med Okayama. 65:105–112. 2011.PubMed/NCBI

21 

Park YS, Lee D, Lee DH, Kim NY, Jeong SH, Kim JW, Hwang JH, Lee SH, Kim JS, Jung HC and Song IS: Assessment of factors affecting the accuracy of endoscopic ultrasonography in T2 stage gastric cancer. Korean J Gastroenterol. 52:86–90. 2008.(In Korean). PubMed/NCBI

22 

Han C, Lin R, Shi H, Liu J, Qian W, Ding Z and Hou X: The role of endoscopic ultrasound on the preoperative T staging of gastric cancer: A retrospective study. Medicine (Baltimore). 95:e45802016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yan Y, Wu Q, Li ZY, Bu ZD and Ji JF: Endoscopic ultrasonography for pretreatment T‑staging of gastric cancer: An in vitro accuracy and discrepancy analysis. Oncol Lett 17: 2849-2855, 2019.
APA
Yan, Y., Wu, Q., Li, Z., Bu, Z., & Ji, J. (2019). Endoscopic ultrasonography for pretreatment T‑staging of gastric cancer: An in vitro accuracy and discrepancy analysis. Oncology Letters, 17, 2849-2855. https://doi.org/10.3892/ol.2019.9920
MLA
Yan, Y., Wu, Q., Li, Z., Bu, Z., Ji, J."Endoscopic ultrasonography for pretreatment T‑staging of gastric cancer: An in vitro accuracy and discrepancy analysis". Oncology Letters 17.3 (2019): 2849-2855.
Chicago
Yan, Y., Wu, Q., Li, Z., Bu, Z., Ji, J."Endoscopic ultrasonography for pretreatment T‑staging of gastric cancer: An in vitro accuracy and discrepancy analysis". Oncology Letters 17, no. 3 (2019): 2849-2855. https://doi.org/10.3892/ol.2019.9920
Copy and paste a formatted citation
x
Spandidos Publications style
Yan Y, Wu Q, Li ZY, Bu ZD and Ji JF: Endoscopic ultrasonography for pretreatment T‑staging of gastric cancer: An in vitro accuracy and discrepancy analysis. Oncol Lett 17: 2849-2855, 2019.
APA
Yan, Y., Wu, Q., Li, Z., Bu, Z., & Ji, J. (2019). Endoscopic ultrasonography for pretreatment T‑staging of gastric cancer: An in vitro accuracy and discrepancy analysis. Oncology Letters, 17, 2849-2855. https://doi.org/10.3892/ol.2019.9920
MLA
Yan, Y., Wu, Q., Li, Z., Bu, Z., Ji, J."Endoscopic ultrasonography for pretreatment T‑staging of gastric cancer: An in vitro accuracy and discrepancy analysis". Oncology Letters 17.3 (2019): 2849-2855.
Chicago
Yan, Y., Wu, Q., Li, Z., Bu, Z., Ji, J."Endoscopic ultrasonography for pretreatment T‑staging of gastric cancer: An in vitro accuracy and discrepancy analysis". Oncology Letters 17, no. 3 (2019): 2849-2855. https://doi.org/10.3892/ol.2019.9920
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