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Article

Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis

  • Authors:
    • Tuy An Trinh
    • Dahae Lee
    • Seonju Park
    • Seung Hyun Kim
    • Jae Gyu Park
    • Ji Hwan Kim
    • Ki Sung Kang
  • View Affiliations / Copyright

    Affiliations: College of Korean Medicine, Gachon University, Seongnam, Gyeonggi 13120, Republic of Korea, College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Gyeonggi 21983, Republic of Korea, Advanced Bio Convergenve Center, Pohang Technopark Foundation, Pohang, North Gyeongsang 37668, Republic of Korea
  • Pages: 2953-2959
    |
    Published online on: January 14, 2019
       https://doi.org/10.3892/ol.2019.9926
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Abstract

Rheum undulatum L. (R. undulatum) is a medicinal plant used for the treatment of inflammatory diseases in East Asian countries. Numerous stilbenes isolated from R. undulatum have been revealed to possess anticancer effects. The aim of the present study was to evaluate the effect of extracts and compounds isolated from R. undulatum on human gastric cancer cell viability and to elucidate their molecular mechanism of action on the apoptosis pathway. The results demonstrated that aloe‑emodin and chrysophanol 1‑O‑β‑D‑glucopyranoside, isolated from the methanolic extract of dried rhizomes of R. undulatum, exhibited anti‑proliferative effects on the human gastric carcinoma cell line AGS, with IC50 values of 84.66±0.44 and 68.28±0.29 µM, respectively. The percentage of apoptotic cells increased significantly following treatment with each compound at a concentration of 100 µM, compared with that in the non‑treated group in the image‑based cytometry assay. Western blot analysis revealed that these compounds activated the caspase cascade and inhibited B‑cell lymphoma‑2, an anti‑apoptotic protein.
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View References

1 

Guggenheim DE and Shah MA: Gastric cancer epidemiology and risk factors. J Surg Oncol. 107:230–236. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Griffin-Sobel JP: Gastrointestinal cancers: Screening and early detection. Semin Oncol Nurs. 33:165–171. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Oh CM, Won YJ, Jung KW, Kong HJ, Cho H, Lee JK, Lee DH and Lee KH; Community of Population-Based Regional Cancer Registries, : Cancer statistics in korea: Incidence, mortality, survival, and prevalence in, 2013. Cancer Res Treat. 48:436–450. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Orditura M, Galizia G, Sforza V, Gambardella V, Fabozzi A, Laterza MM, Andreozzi F, Ventriglia J, Savastano B, Mabilia A, et al: Treatment of gastric cancer. World J Gastroenterol. 20:1635–1649. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Park JM, Lee HJ, Yoo JH, Ko WJ, Cho JY and Hahm KB: Overview of gastrointestinal cancer prevention in Asia. Best Pract Res Clin Gastroenterol. 29:855–867. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Hong NR, Park HS, Ahn TS, Jung MH and Kim BJ: Association of a methanol extract of Rheum undulatum L. Mediated cell death in AGS cells with an intrinsic apoptotic pathway. J Pharmacopuncture. 18:26–32. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Lee W, Yoon G, Hwang YR, Kim YK and Kim SN: Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition. BMB Rep. 45:141–146. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Matsuda H, Tomohiro N, Hiraba K, Harima S, Ko S, Matsuo K, Yoshikawa M and Kubo M: Study on anti-Oketsu activity of rhubarb II. Anti-allergic effects of stilbene components from Rhei undulati Rhizoma (dried rhizome of Rheum undulatum cultivated in Korea). Biol Pharm Bull. 24:264–267. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Matsuda H, Tewtrakul S, Morikawa T and Yoshikawa M: Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): Structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-alpha and IL-4 in RBL-2H3 cells. Bioorg Med Chem. 12:4871–4876. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Dong G, Lee Y, Jeong JH, Zhao HY, Jeon R, Lee HJ and Ryu JH: Stilbenoids from Rheum undulatum protect hepatocytes against oxidative stress through AMPK activation. Phytother Res. 29:1605–1609. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Jo SP, Kim JK and Lim YH: Antihyperlipidemic effects of rhapontin and rhapontigenin from Rheum undulatum in rats fed a high-cholesterol diet. Planta Med. 80:1067–1071. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Song JH, Yang TC, Chang KW, Han SK, Yi HK and Jeon JG: In vitro anti-cariogenic activity of dichloromethane fraction from Rheum undulatum L. Root. Arch Pharm Res. 29:490–496. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Lee HS, Kim JK, Park KT and Lim YH: Rhapontigenin converted from rhapontin purified from Rheum undulatum enhances the inhibition of melanin synthesis. Biosci Biotechnol Biochem. 76:2307–2309. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Choi SZ, Lee SO, Jang KU, Chung SH, Park SH, Kang HC, Yang EY, Cho HJ and Lee KR: Antidiabetic stilbene and anthraquinone derivatives from Rheum undulatum. Arch Pharm Res. 28:1027–1030. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Ko SK, Lee SM and Whang WK: Anti-platelet aggregation activity of stilbene derivatives from Rheum undulatum. Arch Pharm Res. 22:401–403. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Zeng Y, Song JX and Shen XC: Herbal remedies supply a novel prospect for the treatment of atherosclerosis: A review of current mechanism studies. Phytother Res. 26:159–167. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Choi ES, Cho SD, Jeon JG and Cho NP: The apoptotic effect of the hexane extract of Rheum undulatum L. In oral cancer cells through the down-regulation of specificity protein 1 and survivin. Lab Anim Res. 27:19–24. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Venkatesan T, Jeong MJ, Choi YW, Park EJ, EI-Desouky SK and Kim YK: Deoxyrhapontigenin, a natural stilbene derivative isolated from Rheum undulatum L. Induces endoplasmic reticulum stress-mediated apoptosis in human breast cancer cells. Integr Cancer Ther. 15:NP44–NP52. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Kwon GT, Jung JI, Song HR, Woo EY, Jun JG, Kim JK, Her S and Park JH: Piceatannol inhibits migration and invasion of prostate cancer cells: Possible mediation by decreased interleukin-6 signaling. J Nutr Biochem. 23:228–238. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Lee H, Kim Y, Jeong JH, Ryu JH and Kim WY: ATM/CHK/p53 pathway dependent chemopreventive and therapeutic activity on lung cancer by pterostilbene. PLoS One. 11:e01623352016. View Article : Google Scholar : PubMed/NCBI

21 

Sirerol JA, Rodríguez ML, Mena S, Asensi MA, Estrela JM and Ortega AL: Role of natural stilbenes in the prevention of cancer. Oxid Med Cell Longev. 2016:31289512016. View Article : Google Scholar : PubMed/NCBI

22 

Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B and Bao JK: Programmed cell death pathways in cancer: A review of apoptosis, autophagy and programmed necrosis. Cell Prolif. 45:487–498. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Ichim G and Tait SW: A fate worse than death: Apoptosis as an oncogenic process. Nat Rev Cancer. 16:539–548. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Hotchkiss RS, Strasser A, McDunn JE and Swanson PE: Cell death. N Engl J Med. 361:1570–1583. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Chen SH, Lin KY, Chang CC, Fang CL and Lin CP: Aloe-emodin-induced apoptosis in human gastric carcinoma cells. Food Chem Toxicol. 45:2296–2303. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Trinh TA, Lee D, Park S, Kim SH, Park JG, Kim JH and Kang KS: Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis. Oncol Lett 17: 2953-2959, 2019.
APA
Trinh, T.A., Lee, D., Park, S., Kim, S.H., Park, J.G., Kim, J.H., & Kang, K.S. (2019). Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis. Oncology Letters, 17, 2953-2959. https://doi.org/10.3892/ol.2019.9926
MLA
Trinh, T. A., Lee, D., Park, S., Kim, S. H., Park, J. G., Kim, J. H., Kang, K. S."Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis". Oncology Letters 17.3 (2019): 2953-2959.
Chicago
Trinh, T. A., Lee, D., Park, S., Kim, S. H., Park, J. G., Kim, J. H., Kang, K. S."Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis". Oncology Letters 17, no. 3 (2019): 2953-2959. https://doi.org/10.3892/ol.2019.9926
Copy and paste a formatted citation
x
Spandidos Publications style
Trinh TA, Lee D, Park S, Kim SH, Park JG, Kim JH and Kang KS: Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis. Oncol Lett 17: 2953-2959, 2019.
APA
Trinh, T.A., Lee, D., Park, S., Kim, S.H., Park, J.G., Kim, J.H., & Kang, K.S. (2019). Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis. Oncology Letters, 17, 2953-2959. https://doi.org/10.3892/ol.2019.9926
MLA
Trinh, T. A., Lee, D., Park, S., Kim, S. H., Park, J. G., Kim, J. H., Kang, K. S."Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis". Oncology Letters 17.3 (2019): 2953-2959.
Chicago
Trinh, T. A., Lee, D., Park, S., Kim, S. H., Park, J. G., Kim, J. H., Kang, K. S."Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis". Oncology Letters 17, no. 3 (2019): 2953-2959. https://doi.org/10.3892/ol.2019.9926
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