Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Metachronous bilateral triple‑negative breast cancer associated with neurofibromatosis type 1: A case report

  • Authors:
    • Yoji Yamagishi
    • Takahiro Einama
    • Tamio Yamasaki
    • Tomomi Koiwai
    • Miyuki Hiratsuka
    • Makiko Fukumura
    • Takako Kono
    • Hideki Ueno
    • Junji Yamamoto
    • Hitoshi Tsuda
  • View Affiliations / Copyright

    Affiliations: Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan, Department of Surgery, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan
    Copyright: © Yamagishi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2818-2824
    |
    Published online on: January 14, 2019
       https://doi.org/10.3892/ol.2019.9931
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study reports a case of metachronous bilateral breast cancer associated with neurofibromatosis type 1 (NF1). A 67‑year‑old female, who had undergone a radical mastectomy of the left breast 34 years ago due to breast cancer, presented with a tumor of the right breast. The clinical stage of the original breast cancer was T2N0M0 stage IIA and adjuvant chemotherapy had not been not administered. With regard to the right‑sided breast tumor, on physical examination, multiple neurofibromas and café‑au‑lait spots were found to be scattered over the skin. A 2‑cm tumor was palpable. The preoperative histopathological diagnosis of the right‑sided breast tumor was invasive ductal carcinoma, T2N0M0 stage IIA, with negative results for hormone receptors and human epidermal growth factor receptor 2. The patient underwent a modified radical mastectomy and axillary node dissection, and received adjuvant chemotherapy. The bilateral tumors were similar in histology and immunophenotype, each being histological grade 3, triple‑negative and with a basal‑like subtype. Based on a literature review of 90 breast cancers in 84 patients with NF1 (84 patients, 90 breasts), younger age onset, advanced clinical stage and hormone receptor negativity were characteristic features. Bilateral cancer occurred in 8.3% of patients and was characterized by ER negativity, earlier stage and younger age compared with patients with unilateral cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Yoshida Y, Kuramochi A, Ohta A, Furumura M, Imafuku S, Matsuo M, Chikuda H, Funasaki H, Saito K, Saya H, et al: Diagnostic criteria and treatment guidelines for nerve fibrosis type 1 (Recklinghausen's disease). Jpn J Dermatol. 118:1657–1666. 2008.(In Japanese).

2 

Wallace MR, Marchuk DA, Andersen LB, Letcher R, Odeh HM, Saulino AM, Fountain AM, Brereton A, Nicholson J and Mitchell AL: Type 1 neurofibromatosis gene: Identification of a large transcript disrupted in three NF1 patients. Science. 249:181–186. 1990. View Article : Google Scholar : PubMed/NCBI

3 

Gottfried ON, Viskochil DH and Couldwell WT: Neurofibromatosis Type 1 and tumorigenesis: Molecular mechanisms and therapeutic implications. Neurosurg Focus. 28:E82010. View Article : Google Scholar : PubMed/NCBI

4 

Korf BR: Malignancy in neurofibromatosis type 1. Oncologist. 5:477–485. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Uusitalo E, Kallionpää RA, Kurki S, Rantanen M, Pitkäniemi J, Kronqvist P, Härkönen P, Huovinen R, Carpen O, Pöyhönen M, et al: Breast cancer in neurofibromatosis type 1: Overrepresentation of unfavourable prognostic factors. Br J Cancer. 116:211–217. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Ceccaroni M, Genuardi M, Legge F, Lucci-Cordisco E, Carrara S, D'Amico F, Greggi S and Scambia G: BRCA1-related malignancies in a family presenting with von recklinghausen's disease. Gynecol Oncol. 86:375–378. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, et al: American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. Arch Pathol Lab Med. 134:907–922. 2010.PubMed/NCBI

8 

Wolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, Allison KH, Allred DC, Bartlett JM, Bilous M, Fitzgibbons P, et al: Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update. J Clin Oncol. 31:3997–4013. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Dowsett M, Nielsen TO, A'Hern R, Bartlett J, Coombes RC, Cuzick J, Ellis M, Henry NL, Hugh JC, Lively T, et al: Assessment of Ki67 in breast cancer: Recommendations from the international Ki67 in breast cancer working group. J Natl Cancer Inst. 103:1656–1664. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Brierley JD, Gospodarowicz MK and Wittekind C: TNM Classification of Malignant Tumours. 8th. Wiley-Blackwell; Chichester: 2017

11 

Salemis NS, Nakos G, Sambaziotis D and Gourgiotis S: Breast cancer associated with type 1 neurofibromatosis. Breast Cancer. 17:306–309. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Rasmussen SA and Friedman JM: NF1 gene and neurofibromatosis 1. Am J Epidemiol. 151:33–40. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Takano T, Kawashima T, Yamanouchi Y, Kitayama K, Ueno K and Hamaguchi H: Genetics of neurofibromatosis 1 in Japan: Mutation rate and paternal age effect. Hum Genetics. 89:281–286. 1992. View Article : Google Scholar

14 

Sorensen SA, Mulvihill JJ and Nielsen A: Long-term follow-up of von Recklinghausen neurofibromatosis. Survival and malignant neoplasms. N Engl J Med. 314:1010–1015. 1986. View Article : Google Scholar : PubMed/NCBI

15 

Zoller ME, Rembeck B, Oden A, Samuelsson M and Angervall L: Malignant and benign tumors in patients with neurofibromatosis type 1 in a defined Swedish population. Cancer. 79:2125–2131. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Sharif S, Moran A, Huson SM, Iddenden R, Shenton A, Howard E and Evans DG: Women with neurofibromatosis 1 are at a moderately increased risk of developing breast cancer and should be considered for early screening. J Med Genet. 44:481–484. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Walker L, Thompson D, Easton D, Ponder B, Ponder M, Frayling I and Baralle D: A prospective study of neurofibromatosis type 1 cancer incidence in the UK. Br J Cancer. 95:233–238. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Madanikia SA, Bergner A, Ye X and Blakeley JO: Increased risk of breast cancer in women with NF1. Am J Med Genet A. 158a:3056–3060. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Nakamura M, Tangoku A, Kusanagi H, Oka M and Suzuki T: Breast cancer associated with Recklinghausen's disease: Report of a case. Nihon Geka Hokan. 67:3–9. 1998.PubMed/NCBI

20 

Murayama Y, Yamamoto Y, Shimojima N, Takahara T, Kikuchi K, Iida S and Kondo Y: T1 Breast cancer associated with von recklinghausen's neurofibromatosis. Breast Cancer. 6:227–230. 1999. View Article : Google Scholar

21 

Xu GF, Lin B, Tanaka K, Dunn D, Wood D, Gesteland R, White R, Weiss R and Tamanoi F: The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell. 63:835–841. 1990. View Article : Google Scholar : PubMed/NCBI

22 

Jeon YW, Kim RM, Lim ST, Choi HJ and Suh YJ: Early-onset breast cancer in a family with neurofibromatosis type 1 associated with a germline mutation in BRCA1. J Breast Cancer. 18:97–100. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Campos B, Balmana J, Gardenyes J, Valenzuela I, Abad O, Fàbregas P, Volpini V and Díez O: Germline mutations in NF1 and BRCA1 in a family with neurofibromatosis type 1 and early-onset breast cancer. Breast Cancer Res Treat. 139:597–602. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Daly MB, Pilarski R, Berry M, Buys SS, Farmer M, Friedman S, Garber JE, Kauff ND, Khan S, Klein C, et al: NCCN Guidelines insights: Genetic/familial high-risk assessment: Breast and ovarian, version 2.2017. J Natl Compr Canc Netw. 15:9–20. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yamagishi Y, Einama T, Yamasaki T, Koiwai T, Hiratsuka M, Fukumura M, Kono T, Ueno H, Yamamoto J, Tsuda H, Tsuda H, et al: Metachronous bilateral triple‑negative breast cancer associated with neurofibromatosis type 1: A case report. Oncol Lett 17: 2818-2824, 2019.
APA
Yamagishi, Y., Einama, T., Yamasaki, T., Koiwai, T., Hiratsuka, M., Fukumura, M. ... Tsuda, H. (2019). Metachronous bilateral triple‑negative breast cancer associated with neurofibromatosis type 1: A case report. Oncology Letters, 17, 2818-2824. https://doi.org/10.3892/ol.2019.9931
MLA
Yamagishi, Y., Einama, T., Yamasaki, T., Koiwai, T., Hiratsuka, M., Fukumura, M., Kono, T., Ueno, H., Yamamoto, J., Tsuda, H."Metachronous bilateral triple‑negative breast cancer associated with neurofibromatosis type 1: A case report". Oncology Letters 17.3 (2019): 2818-2824.
Chicago
Yamagishi, Y., Einama, T., Yamasaki, T., Koiwai, T., Hiratsuka, M., Fukumura, M., Kono, T., Ueno, H., Yamamoto, J., Tsuda, H."Metachronous bilateral triple‑negative breast cancer associated with neurofibromatosis type 1: A case report". Oncology Letters 17, no. 3 (2019): 2818-2824. https://doi.org/10.3892/ol.2019.9931
Copy and paste a formatted citation
x
Spandidos Publications style
Yamagishi Y, Einama T, Yamasaki T, Koiwai T, Hiratsuka M, Fukumura M, Kono T, Ueno H, Yamamoto J, Tsuda H, Tsuda H, et al: Metachronous bilateral triple‑negative breast cancer associated with neurofibromatosis type 1: A case report. Oncol Lett 17: 2818-2824, 2019.
APA
Yamagishi, Y., Einama, T., Yamasaki, T., Koiwai, T., Hiratsuka, M., Fukumura, M. ... Tsuda, H. (2019). Metachronous bilateral triple‑negative breast cancer associated with neurofibromatosis type 1: A case report. Oncology Letters, 17, 2818-2824. https://doi.org/10.3892/ol.2019.9931
MLA
Yamagishi, Y., Einama, T., Yamasaki, T., Koiwai, T., Hiratsuka, M., Fukumura, M., Kono, T., Ueno, H., Yamamoto, J., Tsuda, H."Metachronous bilateral triple‑negative breast cancer associated with neurofibromatosis type 1: A case report". Oncology Letters 17.3 (2019): 2818-2824.
Chicago
Yamagishi, Y., Einama, T., Yamasaki, T., Koiwai, T., Hiratsuka, M., Fukumura, M., Kono, T., Ueno, H., Yamamoto, J., Tsuda, H."Metachronous bilateral triple‑negative breast cancer associated with neurofibromatosis type 1: A case report". Oncology Letters 17, no. 3 (2019): 2818-2824. https://doi.org/10.3892/ol.2019.9931
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team