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Article

Role of miRNA‑21 in the diagnosis and prediction of treatment efficacy of primary central nervous system lymphoma

  • Authors:
    • Kunpeng Yang
    • Shuye Wang
    • Yafeng Cheng
    • Yaoyao Tian
    • Jinxiao Hou
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
  • Pages: 3475-3481
    |
    Published online on: January 17, 2019
       https://doi.org/10.3892/ol.2019.9941
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Abstract

Primary central nervous system lymphoma (PCNSL) has a poor prognosis and requires early diagnosis and treatment. The aim of the present study was to investigate the difference between microRNA‑21 (miRNA‑21) expression in the plasma and cerebrospinal fluid (CSF) of patients with PCNSL, and to discuss the importance of miRNA‑21 in its diagnostic and therapeutic evaluation. The research subjects were confirmed as patients with PCNSL with histopathological lesions at The First Affiliated Hospital of Harbin Medical University (Harbin, China) between December 2011 and 2017. Comparisons were drawn between the PCNSL, glioblastoma and the healthy control groups. CSF and plasma specimens were obtained from patients with PCNSL prior to chemotherapy, and CSF specimens were also obtained following chemotherapy. Plasma specimens were taken from patients with glioblastoma and the healthy control group. Using reverse transcription‑quantitative polymerase chain reaction analysis, it was revealed that plasma miRNA‑21 expression level had a notable diagnostic value in distinguishing PCNSL from glioblastoma, another common neurological tumor. Moreover, miRNA‑21 expression levels in the plasma correlated positively with those in the CSF. Therefore, miRNA‑21 in the plasma may be used as a novel diagnostic biomarker to distinguish patients with PCNSL from those with glioblastoma, whereas miRNA‑21 in the CSF may have potential as a predictor of chemotherapeutic effect in PCNSL.
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Copy and paste a formatted citation
Spandidos Publications style
Yang K, Wang S, Cheng Y, Tian Y and Hou J: Role of miRNA‑21 in the diagnosis and prediction of treatment efficacy of primary central nervous system lymphoma. Oncol Lett 17: 3475-3481, 2019.
APA
Yang, K., Wang, S., Cheng, Y., Tian, Y., & Hou, J. (2019). Role of miRNA‑21 in the diagnosis and prediction of treatment efficacy of primary central nervous system lymphoma. Oncology Letters, 17, 3475-3481. https://doi.org/10.3892/ol.2019.9941
MLA
Yang, K., Wang, S., Cheng, Y., Tian, Y., Hou, J."Role of miRNA‑21 in the diagnosis and prediction of treatment efficacy of primary central nervous system lymphoma". Oncology Letters 17.3 (2019): 3475-3481.
Chicago
Yang, K., Wang, S., Cheng, Y., Tian, Y., Hou, J."Role of miRNA‑21 in the diagnosis and prediction of treatment efficacy of primary central nervous system lymphoma". Oncology Letters 17, no. 3 (2019): 3475-3481. https://doi.org/10.3892/ol.2019.9941
Copy and paste a formatted citation
x
Spandidos Publications style
Yang K, Wang S, Cheng Y, Tian Y and Hou J: Role of miRNA‑21 in the diagnosis and prediction of treatment efficacy of primary central nervous system lymphoma. Oncol Lett 17: 3475-3481, 2019.
APA
Yang, K., Wang, S., Cheng, Y., Tian, Y., & Hou, J. (2019). Role of miRNA‑21 in the diagnosis and prediction of treatment efficacy of primary central nervous system lymphoma. Oncology Letters, 17, 3475-3481. https://doi.org/10.3892/ol.2019.9941
MLA
Yang, K., Wang, S., Cheng, Y., Tian, Y., Hou, J."Role of miRNA‑21 in the diagnosis and prediction of treatment efficacy of primary central nervous system lymphoma". Oncology Letters 17.3 (2019): 3475-3481.
Chicago
Yang, K., Wang, S., Cheng, Y., Tian, Y., Hou, J."Role of miRNA‑21 in the diagnosis and prediction of treatment efficacy of primary central nervous system lymphoma". Oncology Letters 17, no. 3 (2019): 3475-3481. https://doi.org/10.3892/ol.2019.9941
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