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Article Open Access

MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2

  • Authors:
    • Xiaori Huang
    • Lei Wang
    • Wei Liu
    • Fei Li
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, People's Hospital of Rizhao, Rizhao, Shandong 276826, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3425-3431
    |
    Published online on: January 21, 2019
       https://doi.org/10.3892/ol.2019.9954
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Abstract

Increasing number of microRNAs (miRNAs) have been reported to play an important role in the development and progression of non-small cell lung cancer (NSCLC). In particular, microRNA-497-5p (miR-497-5p) has been proposed as a tumor suppressor miRNA in human cancers. However, the role of miR-497-5p and its potential molecular mechanism associated with NSCLC are less studied. Therefore, the role of miR-497-5p in the pathogenesis of NSCLC was investigated. In the present study, the expression of miR-497-5p was significantly downregulated in NSCLC. Moreover, overexpression of miR-497-5p inhibited the proliferation and invasion of NSCLC cells by suppressing FGF2. In addition, FGF2 was a downstream target of miR-497-5p in NSCLC. FGF2 was upregulated in NSCLC promoting cell proliferation and invasion. Overexpression of FGF2 impaired the inhibitory effect of miR-497-5p in NSCLC. Taken together, these results demonstrate that miR-497-5p is a tumor suppressor miRNA and demonstrate its potential for future use in the treatment of human NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Huang X, Wang L, Liu W and Li F: MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2. Oncol Lett 17: 3425-3431, 2019.
APA
Huang, X., Wang, L., Liu, W., & Li, F. (2019). MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2. Oncology Letters, 17, 3425-3431. https://doi.org/10.3892/ol.2019.9954
MLA
Huang, X., Wang, L., Liu, W., Li, F."MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2". Oncology Letters 17.3 (2019): 3425-3431.
Chicago
Huang, X., Wang, L., Liu, W., Li, F."MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2". Oncology Letters 17, no. 3 (2019): 3425-3431. https://doi.org/10.3892/ol.2019.9954
Copy and paste a formatted citation
x
Spandidos Publications style
Huang X, Wang L, Liu W and Li F: MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2. Oncol Lett 17: 3425-3431, 2019.
APA
Huang, X., Wang, L., Liu, W., & Li, F. (2019). MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2. Oncology Letters, 17, 3425-3431. https://doi.org/10.3892/ol.2019.9954
MLA
Huang, X., Wang, L., Liu, W., Li, F."MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2". Oncology Letters 17.3 (2019): 3425-3431.
Chicago
Huang, X., Wang, L., Liu, W., Li, F."MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2". Oncology Letters 17, no. 3 (2019): 3425-3431. https://doi.org/10.3892/ol.2019.9954
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