ZFP91 zinc finger protein expression pattern in normal tissues and cancers

  • Authors:
    • Lukasz Paschke
    • Karol Jopek
    • Marta Szyszka
    • Marianna Tyczewska
    • Ludwik K. Malendowicz
    • Marcin Rucinski
  • View Affiliations

  • Published online on: January 23, 2019     https://doi.org/10.3892/ol.2019.9963
  • Pages: 3599-3606
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Abstract

Zinc finger protein 91 (ZFP91) gene has been recently acknowledged to possess oncogenic properties. To date, its expression has been examined only in a handful of human organs and cancer types. The aim of the present study was to characterize, for the first time, the ZFP91 expression pattern in a range of human tissues and cancer types. ZFP91 mRNA expression was examined using Cancer Survey cDNA sets. Utilized cDNA samples represented 15 human organs and 17 cancer types. ZFP91 mRNA expression was the highest in the testes and lymph nodes. It was downregulated in testis cancer, lymphoma and thyroid cancer, and upregulated in prostate cancer. Among the analyzed cancer types, ZFP91 expression was markedly elevated in sarcomas and melanoma. On a protein level, a large‑scale reverse phase protein array was employed providing samples from 11 organ types and from cancers derived from these organs. ZFP91 protein expression was revealed to be generally stable across the tested samples and was only moderately elevated in breast, ovarian and pancreatic cancers. To the best of our knowledge, this is the first study to thoroughly analyze the ZFP91 expression pattern in human tissues and cancers. The obtained results provide the foundation for further work aiming to reveal its full biological significance.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Paschke L, Jopek K, Szyszka M, Tyczewska M, Malendowicz LK and Rucinski M: ZFP91 zinc finger protein expression pattern in normal tissues and cancers. Oncol Lett 17: 3599-3606, 2019
APA
Paschke, L., Jopek, K., Szyszka, M., Tyczewska, M., Malendowicz, L.K., & Rucinski, M. (2019). ZFP91 zinc finger protein expression pattern in normal tissues and cancers. Oncology Letters, 17, 3599-3606. https://doi.org/10.3892/ol.2019.9963
MLA
Paschke, L., Jopek, K., Szyszka, M., Tyczewska, M., Malendowicz, L. K., Rucinski, M."ZFP91 zinc finger protein expression pattern in normal tissues and cancers". Oncology Letters 17.3 (2019): 3599-3606.
Chicago
Paschke, L., Jopek, K., Szyszka, M., Tyczewska, M., Malendowicz, L. K., Rucinski, M."ZFP91 zinc finger protein expression pattern in normal tissues and cancers". Oncology Letters 17, no. 3 (2019): 3599-3606. https://doi.org/10.3892/ol.2019.9963