Effects of dezocine and sufentanyl for postoperative analgesia on activity of NK, CD4+ and CD8+ cells in patients with breast cancer

Wang,Fei; Zhang,Xue; Wang,Huihui; Liu,Yi

doi:10.3892/ol.2019.9964

Effects of dezocine and sufentanyl for postoperative analgesia on activity of NK, CD4+ and CD8+ cells in patients with breast cancer

Authors:
- Fei Wang
- Xue Zhang
- Huihui Wang
- Yi Liu
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Affiliations: Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China
Published online on: January 23, 2019 https://doi.org/10.3892/ol.2019.9964
Pages: 3392-3398

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Abstract

The effects of dezocine and sufentanyl on the activity of natural killer (NK), CD4+ and CD8+ cells in patients with breast cancer undergoing postoperative analgesia after radical mastectomy were compared. The clinical data of 76 female patients undergoing radical mastectomy in the Fudan University Shanghai Cancer Center from January 2015 to October 2017 were analyzed retrospectively. Forty-two patients treated with dezocine were group D and 34 patients with sufentanyl were group S. Visual analogue scale (VAS) was used to evaluate the analgesic effect at 3, 12, 24, 48 h after surgery. There was no significant difference in VAS score, NK cells, CD4+ cells, and CD8+ cell vitality at 3 h postoperatively between the two groups (P>0.05), and VAS score at 12, 24 and 48 h postoperatively in the S group was significantly lower than that in group D (P<0.05). The activity of NK cells and CD4+ cells at 3, 12, 24 and 48 h after surgery in group D was significantly higher than that in group S, and the diffe-rence was statistically significant (P<0.05). The activity of CD8+ cells at 3, 12, 24 and 48 h after surgery in group D was significantly lower than that in group S, and the difference was statistically significant (P<0.05). The analgesic effect of dezocine was slightly worse than that of sufentanyl, but it was more beneficial to the recovery of early postoperative immune function.

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1	Dolin SJ, Cashman JN and Bland JM: Effectiveness of acute postoperative pain management: I. Evidence from published data. Br J Anaesth. 89:409–423. 2002. View Article : Google Scholar : PubMed/NCBI
2	Apfelbaum JL, Chen C, Mehta SS and Gan TJ: Postoperative pain experience: Results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 97:534–540. 2003. View Article : Google Scholar : PubMed/NCBI
3	Rawal N, Hylander J, Nydahl PA, Olofsson I and Gupta A: Survey of postoperative analgesia following ambulatory surgery. Acta Anaesthesiol Scand. 41:1017–1022. 1997. View Article : Google Scholar : PubMed/NCBI
4	Kehlet H, Gray AW, Bonnet F, Camu F, Fischer HB, McCloy RF, Neugebauer EA, Puig MM, Rawal N and Simanski CJ: A procedure-specific systematic review and consensus recommendations for postoperative analgesia following laparoscopic cholecystectomy. Surg Endosc. 19:1396–1415. 2005. View Article : Google Scholar : PubMed/NCBI
5	Huang R, Hayashi Y, Yan X, Bu J, Wang J, Zhang Y, Zhou Y, Tang Y, Wu L, Xu Z, et al: HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis. Haematologica. 102:1956–1968. 2017. View Article : Google Scholar : PubMed/NCBI
6	Wu L, Wang Z, Chen X, Wang YN and Wang JS: Application of measuring human peripheral NK cell activity with flow cytometry in diagnosis for hemophagocytic lymphohistiocytosis. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 17:1497–1501. 2009.(In Chinese). PubMed/NCBI
7	Beilin B, Shavit Y, Hart J, Mordashov B, Cohn S, Notti I and Bessler H: Effects of anesthesia based on large versus small doses of fentanyl on natural killer cell cytotoxicity in the perioperative period. Anesth Analg. 82:492–497. 1996. View Article : Google Scholar : PubMed/NCBI
8	Liu R, Huang X-P, Yeliseev A, Xi J and Roth BL: Novel molecular targets of dezocine and their clinical implications. Anesthesiology. 120:714–723. 2014. View Article : Google Scholar : PubMed/NCBI
9	Sun ZT, Yang CY, Cui Z, Zhang J and Han XP: Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction: A double-blinded, prospective, randomized, controlled trial. J Anesth. 25:860–863. 2011. View Article : Google Scholar : PubMed/NCBI
10	Soleimani A, Kiabi FH, Habibi MR, Emami Zeydi A, Assarroudi A and Sharifi H: Intravenous dezocine for suppressing fentanyl-induced cough during general anesthesia induction: A potentially effective and clinically feasible method. J Anaesthesiol Clin Pharmacol. 33:556–557. 2017.PubMed/NCBI
11	Thomson IR, Harding G and Hudson RJ: A comparison of fentanyl and sufentanil in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 14:652–656. 2000. View Article : Google Scholar : PubMed/NCBI
12	Madej TH and Strunin L: Comparison of epidural fentanyl with sufentanil. Analgesia and side effects after a single bolus dose during elective caesarean section. Anaesthesia. 42:1156–1161. 1987. View Article : Google Scholar : PubMed/NCBI
13	Jiang Z, Dai JQ, Shi C, Zeng WS, Jiang RC and Tu WF: Influence of patient-controlled i.v. analgesia with opioids on supraventricular arrhythmias after pulmonary resection. Br J Anaesth. 103:364–368. 2009. View Article : Google Scholar : PubMed/NCBI
14	Beilin B, Shavit Y, Trabekin E, Mordashev B, Mayburd E, Zeidel A and Bessler H: The effects of postoperative pain management on immune response to surgery. Anesth Analg. 97:822–827. 2003. View Article : Google Scholar : PubMed/NCBI
15	Barbera-Guillem E, Nelson MB, Barr B, Nyhus JK, May KF Jr, Feng L and Sampsel JW: B lymphocyte pathology in human colorectal cancer. Experimental and clinical therapeutic effects of partial B cell depletion. Cancer Immunol Immunother. 48:541–549. 2000. View Article : Google Scholar : PubMed/NCBI
16	Pilla L, Squarcina P, Coppa J, Mazzaferro V, Huber V, Pende D, Maccalli C, Sovena G, Mariani L, Castelli C, et al: Natural killer and NK-like T-cell activation in colorectal carcinoma patients treated with autologous tumor-derived heat shock protein 96. Cancer Res. 65:3942–3949. 2005. View Article : Google Scholar : PubMed/NCBI
17	Kim R, Emi M and Tanabe K: Cancer immunoediting from immune surveillance to immune escape. Immunology. 121:1–14. 2007. View Article : Google Scholar : PubMed/NCBI
18	Yang XH, Bai Q, Lv MM, Fu HG, Dong TL and Zhou Z: Effect of dexmedetomidine on immune function of patients undergoing radical mastectomy: A double blind and placebo control study. Eur Rev Med Pharmacol Sci. 21:1112–1116. 2017.PubMed/NCBI
19	Hemmati N and Zokaei AH: Comparison of the effect of anesthesia with midazolam-fentanyl versus propofol-remifentanil on bispectral index in patients undergoing coronary artery bypass graft. Glob J Health Sci. 7:233–238. 2015. View Article : Google Scholar : PubMed/NCBI
20	Wu FX, Pan RR, Yu WF and Liu R: The anti-nociception effect of dezocine in a rat neuropathic pain model. Transl Perioper Pain Med. 1:5–8. 2014.PubMed/NCBI
21	Wang YX, Mao XF, Li TF, Gong N and Zhang MZ: Dezocine exhibits antihypersensitivity activities in neuropathy through spinal µ-opioid receptor activation and norepinephrine reuptake inhibition. Sci Rep. 7:431372017. View Article : Google Scholar : PubMed/NCBI
22	Barrett AC, Smith ES and Picker MJ: Sex-related differences in mechanical nociception and antinociception produced by µ- and κ-opioid receptor agonists in rats. Eur J Pharmacol. 452:163–173. 2002. View Article : Google Scholar : PubMed/NCBI
23	Terner JM, Barrett AC, Grossell E and Picker MJ: Influence of gonadectomy on the antinociceptive effects of opioids in male and female rats. Psychopharmacology (Berl). 163:183–193. 2002. View Article : Google Scholar : PubMed/NCBI
24	Feng C, Feng M, Jiao R, Liu D, Jin Y, Zhao X and Xiao R: Effect of dezocine on IL-12 and IL-10 secretion and lymphocyte activation by culturing dendritic cells from human umbilical cord blood. Eur J Pharmacol. 796:110–114. 2017. View Article : Google Scholar : PubMed/NCBI
25	Pandit UA, Kothary SP and Pandit SK: Intravenous dezocine for postoperative pain: A double-blind, placebo-controlled comparison with morphine. J Clin Pharmacol. 26:275–280. 1986. View Article : Google Scholar : PubMed/NCBI
26	Sayed JA, Abd Elshafy SK, Kamel EZ, Fathy Riad MA, Mahmoud AA and Khalaf GS: The impact of caudally administered tramadol on immune response and analgesic efficacy for pediatric patients: A comparative randomized clinical trial. Korean J Pain. 31:206–214. 2018. View Article : Google Scholar : PubMed/NCBI