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Case Report

Rechallenge of carboplatin‑gemcitabine based chemotherapy for rapidly progressing metastatic collecting duct carcinoma of the kidney leading to a delayed and durable complete response: A case report

  • Authors:
    • Domitille Dano
    • Clémence Delteil
    • Romain Boissier
    • Véronique Delaporte
    • Paul Habert
    • Sébastien Salas
    • Florence Duffaud
    • Jean‑Laurent Deville
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Assistance Publique‑Hôpitaux de Marseille, Timone University Hospital, 13385 Marseille Cedex 5, France, Department of Pathology and Neuropathology, Assistance Publique‑Hôpitaux de Marseille, Timone University Hospital, 13385 Marseille Cedex 5, France, Department of Urology and Renal Transplantation, Assistance Publique‑Hôpitaux de Marseille, Conception University Hospital, 13385 Marseille Cedex 5, France, Department of Radiology, Assistance Publique‑Hôpitaux de Marseille, Conception University Hospital, 13385 Marseille Cedex 5, France
  • Pages: 3576-3580
    |
    Published online on: January 29, 2019
       https://doi.org/10.3892/ol.2019.9991
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Abstract

Renal collecting duct carcinoma (CDC) is a rare and highly aggressive subtype of kidney cancer with poor prognosis. We report a case of one patient, who was successfully treated with gemcitabine‑platin based chemotherapy for polymetastatic renal CDC, and experienced a late and prolonged complete remission. In June 2014, a 69‑year‑old male patient was diagnosed with non‑metastatic renal CDC. Nephrouretectomy was firstly performed. In December 2014, he developed a loco‑regional recurrence with bilateral lung metastases. The patient started a course of gemcitabine‑carboplatin (GC)‑based first‑line chemotherapy and received 6 cycles, which ended in May 2015. Computed tomography (CT) scan evaluation displayed an objective response according to RECIST 1.1 criteria and a follow‑up of the patient was conducted. In August 2015, he had a second local relapse with new lung metastases. Despite a short disease‑free interval, 6 cycles of the same GC regimen were required, which ended in February 2016. The patient firstly exhibited a partial objective response after the first 3 cycles and a stable disease at the end of chemotherapy. During the follow‑up, a CT scan of his chest, abdomen and pelvis was performed every 3 months. From September 2016 to May 2017, despite no new specific treatments for his metastatic disease, the patient again experienced an objective and confirmed response on each CT‑scan evaluation until complete remission in May 2017. This case report highlights the efficacy of GC‑based chemotherapy, which is able to provide a durable and sometimes complete response in metastatic renal CDC, and suggests the potential of rechallenging with the same chemotherapy regimen, despite a short disease‑free interval. The originality of this case was demonstrated by the delayed complete response more than one year after the end of GC‑based second line chemotherapy. The patient remained disease‑free at his last CT‑scan evaluation in April 2018.
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1 

McDougal W, Wein A, Kavoussi L, Novick A, Partin A, Peters C and Ramchandani P: Malignant renal tumors. In: Campbell-walsh Urology 10th Edition Review. Elsevier Health Sciences. 14362011.

2 

Andola SK, Laheru V and Patil S: Collecting duct carcinoma of the kidney. J Sci Res. 6:46–48. 2013.

3 

Méjean A, Rouprêt M, Larousserie F, Hopirtean V, Thiounn N and Dufour B: Is there a place for radical nephrectomy in the presence of metastatic collecting duct (Bellini) carcinoma? J Urol. 169:1287–1290. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Peyromaure M, Thiounn N, Scotté F, Vieillefond A, Debré B and Oudard S: Collecting duct carcinoma of the kidney: A clinicopathological study of 9 cases. J Urol. 170:1138–1140. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Tokuda N, Naito S, Matsuzaki O, Nagashima Y, Ozono S and Igarashi T; Japanese Society of Renal Cancer: Collecting duct (Bellini duct) renal cell carcinoma: A nationwide survey in Japan. J Urol. 176:40–43. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Oudard S, Banu E, Vieillefond A, Fournier L, Priou F, Medioni J, Banu A, Duclos B, Rolland F, Escudier B, et al: Prospective multicenter phase II study of gemcitabine plus platinum salt for metastatic collecting duct carcinoma: Results of a GETUG (Groupe d'Etudes des Tumeurs Uro-Génitales) study. J Urol. 177:1698–1702. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Dason S, Allard C, Sheridan-Jonah A, Gill J, Jamshaid H, Aziz T, Kajal B and Kapoor A: Management of renal collecting duct carcinoma: A systematic review and the McMaster experience. Curr Oncol. 20:e223–e232. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Barrascout E, Beuselinck B, Ayllon J, Bättig B, Moch H, Teghom C and Oudard S: Complete remission of pulmonary metastases of Bellini duct carcinoma with cisplatin, gemcitabine and bevacizumab. Am J Case Rep. 13:1–2. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Pécuchet N, Bigot F, Gachet J, Massard C, Albiges L, Teghom C, Allory Y, Méjean A, Escudier B and Oudard S: Triple combination of bevacizumab, gemcitabine and platinum salt in metastatic collecting duct carcinoma. Ann Oncol. 24:2963–2967. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Mennitto A, Verzoni E, Peverelli G, Alessi A and Procopio G: Management of metastatic collecting duct carcinoma: An encouraging result in a patient treated with cabozantinib. Clin Genitourin Cancer. 16:e521–e523. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Selli C, Amorosi A, Vona G, Sestini R, Tmvaglini F, Bartoletti R and Orlando C: Retrospective evaluation of c-erbb-2 oncogene amplification using competitive PCR in collecting duct carcinoma of the kidney. J Urol. 158:245–247. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Bronchud MH, Castillo S, Escriva de Romaní S, Mourelo S, Fernández A, Baena C, Murillo J, Julia JC, Esquius J, Romero R and Andreu X: HER2 blockade in metastatic collecting duct carcinoma (CDC) of the kidney: A case report. Onkologie. 35:776–779. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Procopio G, Verzoni E, Iacovelli R, Colecchia M, Torelli T and Mariani L: Is there a role for targeted therapies in the collecting ducts of Bellini carcinoma? Efficacy data from a retrospective analysis of 7 cases. Clin Exp Nephrol. 16:464–467. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Koshkin VS, Barata PC, Zhang T, George DJ, Atkins MB, Kelly WJ, Vogelzang NJ, Pal SK, Hsu J, Appleman LJ, et al: Clinical activity of nivolumab in patients with non-clear cell renal cell carcinoma. J Immunother Cancer. 6:92018. View Article : Google Scholar : PubMed/NCBI

15 

Mizutani K, Horie K, Nagai S, Tsuchiya T, Saigo C, Kobayashi K, Miyazaki T and Deguchi T: Response to nivolumab in metastatic collecting duct carcinoma expressing PD-L1: A case report. Mol Clin Oncol. 7:988–990. 2017.PubMed/NCBI

16 

Malouf GG, Compérat E, Yao H, Mouawad R, Lindner V, Rioux-Leclercq N, Verkarre V, Leroy X, Dainese L, Classe M, et al: Unique transcriptomic profile of collecting duct carcinomas relative to upper tract urothelial carcinomas and other kidney carcinomas. Sci Rep. 6:309882016. View Article : Google Scholar : PubMed/NCBI

17 

Pal SK, Choueiri TK, Wang K, Khaira D, Karam JA, Van Allen E, Palma NA, Stein MN, Johnson A, Squillace R, et al: Characterization of clinical cases of collecting duct carcinoma of the kidney assessed by comprehensive genomic profiling. Eur Urol. 70:516–521. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dano D, Delteil C, Boissier R, Delaporte V, Habert P, Salas S, Duffaud F and Deville JL: Rechallenge of carboplatin‑gemcitabine based chemotherapy for rapidly progressing metastatic collecting duct carcinoma of the kidney leading to a delayed and durable complete response: A case report. Oncol Lett 17: 3576-3580, 2019.
APA
Dano, D., Delteil, C., Boissier, R., Delaporte, V., Habert, P., Salas, S. ... Deville, J. (2019). Rechallenge of carboplatin‑gemcitabine based chemotherapy for rapidly progressing metastatic collecting duct carcinoma of the kidney leading to a delayed and durable complete response: A case report. Oncology Letters, 17, 3576-3580. https://doi.org/10.3892/ol.2019.9991
MLA
Dano, D., Delteil, C., Boissier, R., Delaporte, V., Habert, P., Salas, S., Duffaud, F., Deville, J."Rechallenge of carboplatin‑gemcitabine based chemotherapy for rapidly progressing metastatic collecting duct carcinoma of the kidney leading to a delayed and durable complete response: A case report". Oncology Letters 17.3 (2019): 3576-3580.
Chicago
Dano, D., Delteil, C., Boissier, R., Delaporte, V., Habert, P., Salas, S., Duffaud, F., Deville, J."Rechallenge of carboplatin‑gemcitabine based chemotherapy for rapidly progressing metastatic collecting duct carcinoma of the kidney leading to a delayed and durable complete response: A case report". Oncology Letters 17, no. 3 (2019): 3576-3580. https://doi.org/10.3892/ol.2019.9991
Copy and paste a formatted citation
x
Spandidos Publications style
Dano D, Delteil C, Boissier R, Delaporte V, Habert P, Salas S, Duffaud F and Deville JL: Rechallenge of carboplatin‑gemcitabine based chemotherapy for rapidly progressing metastatic collecting duct carcinoma of the kidney leading to a delayed and durable complete response: A case report. Oncol Lett 17: 3576-3580, 2019.
APA
Dano, D., Delteil, C., Boissier, R., Delaporte, V., Habert, P., Salas, S. ... Deville, J. (2019). Rechallenge of carboplatin‑gemcitabine based chemotherapy for rapidly progressing metastatic collecting duct carcinoma of the kidney leading to a delayed and durable complete response: A case report. Oncology Letters, 17, 3576-3580. https://doi.org/10.3892/ol.2019.9991
MLA
Dano, D., Delteil, C., Boissier, R., Delaporte, V., Habert, P., Salas, S., Duffaud, F., Deville, J."Rechallenge of carboplatin‑gemcitabine based chemotherapy for rapidly progressing metastatic collecting duct carcinoma of the kidney leading to a delayed and durable complete response: A case report". Oncology Letters 17.3 (2019): 3576-3580.
Chicago
Dano, D., Delteil, C., Boissier, R., Delaporte, V., Habert, P., Salas, S., Duffaud, F., Deville, J."Rechallenge of carboplatin‑gemcitabine based chemotherapy for rapidly progressing metastatic collecting duct carcinoma of the kidney leading to a delayed and durable complete response: A case report". Oncology Letters 17, no. 3 (2019): 3576-3580. https://doi.org/10.3892/ol.2019.9991
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