The oncogenic role of microRNA‑500a in colorectal cancer
Affiliations: First Department of General Surgery, Chengdu Shangjin Nan Fu Hospital, Chengdu, Sichuan 510117, P.R. China, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
- Published online on: January 10, 2020 https://doi.org/10.3892/ol.2020.11291
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et al. This is an open access article distributed under the
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Colorectal cancer (CRC) is a common and lethal disease, and microRNAs (miRNAs/miRs) serve an important role in the pathogenesis of CRC. miR‑500a is a novel miRNA, and although its function has been studied in hepatocellular carcinoma, the function of miR‑500a in CRC remains unknown. In the present study, the function of miR‑500a in CRC was investigated. The expression levels of miR‑500a in cells and tissues were investigated using reverse transcription‑quantitative PCR. Cell proliferation was tested using MTT assay and migration was assessed using Transwell systems. The results revealed that there were higher levels of miR‑500a in tumor tissue compared with in normal tissue. Inhibition of miR‑500a suppressed cell growth and migration, whereas overexpression of miR‑500a promoted cell growth and migration. Additionally, it was revealed that miR‑500a may target the 3'‑untranslated region of the phosphatase and tensin homolog gene. In conclusion, the present study demonstrated that miR‑500a may serve an oncogenic role in CRC.