Open Access

MICA enhances sensitivity to cisplatin in patients with extensive small cell lung cancer via downregulation of ABCG2

  • Authors:
    • Yufeng Wu
    • Hong Tang
    • Ruirui Si
    • Suhua Xia
    • Ruilin Wang
    • Qiming Wang
  • View Affiliations

  • Published online on: May 19, 2020     https://doi.org/10.3892/ol.2020.11646
  • Pages: 1143-1152
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Immunotherapy utilizing natural killer cell‑activated receptor natural‑killer group‑2 member D ligands (NKG2DLs) has had preclinical success in the treatment of small cell lung cancer. The present study aimed to investigate the association between NKG2Ls and chemoresistance. The mRNA expression of six NKG2DLs associated with progression‑free survival time (PFS) and first‑line chemotherapy were assessed in the present study. Major histocompatibility complex class I polypeptide‑related sequence A (MICA)‑overexpressing NCI‑H446 cell line was constructed, and the mRNA expression levels of 11 genes associated with chemotherapy sensitivity were determined. The results demonstrated that MICA was positively and significantly associated with PFS. Furthermore, MICA expression was 1.6 times higher in patients with prolonged PFS compared with the rapid chemoresistance group. ATP binding cassette subfamily G member 2 (ABCG2) mRNA expression was associated with chemotherapy resistance and significantly downregulated in the cell line overexpressing MICA. Moreover, following addition of nicardipine (an ABCG2 inhibitor), chemotherapeutic sensitivity increased in the MICA‑overexpressing cell line. Taken together, the results of the present study suggested that MICA may enhance the chemosensitivity of patients with extensive small cell lung cancer by downregulating ABCG2.

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August-2020
Volume 20 Issue 2

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Copy and paste a formatted citation
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Spandidos Publications style
Wu Y, Tang H, Si R, Xia S, Wang R and Wang Q: MICA enhances sensitivity to cisplatin in patients with extensive small cell lung cancer via downregulation of ABCG2. Oncol Lett 20: 1143-1152, 2020
APA
Wu, Y., Tang, H., Si, R., Xia, S., Wang, R., & Wang, Q. (2020). MICA enhances sensitivity to cisplatin in patients with extensive small cell lung cancer via downregulation of ABCG2. Oncology Letters, 20, 1143-1152. https://doi.org/10.3892/ol.2020.11646
MLA
Wu, Y., Tang, H., Si, R., Xia, S., Wang, R., Wang, Q."MICA enhances sensitivity to cisplatin in patients with extensive small cell lung cancer via downregulation of ABCG2". Oncology Letters 20.2 (2020): 1143-1152.
Chicago
Wu, Y., Tang, H., Si, R., Xia, S., Wang, R., Wang, Q."MICA enhances sensitivity to cisplatin in patients with extensive small cell lung cancer via downregulation of ABCG2". Oncology Letters 20, no. 2 (2020): 1143-1152. https://doi.org/10.3892/ol.2020.11646