Open Access

Expression of Krüppel-like factor 9 in breast cancer patients and its effect on prognosis

  • Authors:
    • Zirong Jiang
    • Zhiping Xu
    • Tinghui Hu
    • Bin Song
    • Feng Li
    • Kaiyin Wang
  • View Affiliations

  • Published online on: May 29, 2020     https://doi.org/10.3892/ol.2020.11689
  • Pages: 1311-1317
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Expression of Krüppel-like factor 9 (KLF9) in breast cancer tissue and its influence on prognosis was investigated. Sixty-eight patients with breast cancer admitted in Ningde Hospital Affiliated to Fujian Medical University from February 2014 to August 2015 were collected, and the expression level of KLF9 in cancerous tissue (n=68) and normal tissue (n=68) of the patients was measured by quantitative real-time PCR (RT-qPCR). The relationship between the expression and clinical pathological features and prognosis of patients was analyzed. The expression level of KLF9 in cancerous tissue was significantly lower than that in normal tissue (P<0.05). The expression in breast cancer tissue was not significantly correlated with age, height, menstrual status, lymph node metastasis or pathological differentiation (P>0.05), but was significantly correlated with tumor size and clinical stage (P<0.05). The 1-, 2-, and 3-year survival rates in the high expression group were significantly higher than those in the low expression group (P<0.001). Univariate Cox regression analysis was carried out according to the 3-year survival of the patients, and the results showed that tumor size (P=0.009), lymph node metastasis (P=0.002), pathological differentiation (P=0.015), clinical stage (P=0.013), and KLF9 (P=0.018) were factors affecting the survival of breast cancer patients. Subsequently, multivariate Cox regression analysis of the indicators with differences showed that those indicators were independent predictors of survival of breast cancer patients. In conclusion, KLF9 expression is low in breast cancer tissue, and its expression level is related to tumor size and clinical stage. Moreover, tumor size >5 cm, lymph node metastasis, low pathological differentiation, high clinical stage and low expression of KLF9 are all important factors that cause death of patients.

Related Articles

Journal Cover

August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Jiang, Z., Xu, Z., Hu, T., Song, B., Li, F., & Wang, K. (2020). Expression of Krüppel-like factor 9 in breast cancer patients and its effect on prognosis. Oncology Letters, 20, 1311-1317. https://doi.org/10.3892/ol.2020.11689
MLA
Jiang, Z., Xu, Z., Hu, T., Song, B., Li, F., Wang, K."Expression of Krüppel-like factor 9 in breast cancer patients and its effect on prognosis". Oncology Letters 20.2 (2020): 1311-1317.
Chicago
Jiang, Z., Xu, Z., Hu, T., Song, B., Li, F., Wang, K."Expression of Krüppel-like factor 9 in breast cancer patients and its effect on prognosis". Oncology Letters 20, no. 2 (2020): 1311-1317. https://doi.org/10.3892/ol.2020.11689