Effects of S‑1 combined with palliative care on immune function and quality of life of patients with advanced stomach cancer

  • Authors:
    • Ying Wang
    • Guozhong Li
  • View Affiliations

  • Published online on: June 9, 2020     https://doi.org/10.3892/ol.2020.11720
  • Pages: 2021-2027
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to investigate the effects of S‑1 combined with palliative care (PC) on the immune function and quality of life (QOL) of patients with advanced stomach cancer (ASC). In this prospective study, 168 patients with ASC admitted to our hospital from September 2016 to March 2018 were enrolled as research objects. Seventy‑seven cases were treated with S‑1 alone (single drug group, SDG), while another 91 cases were treated with S‑1 combined with PC (combined drug group, CDG). The effects of the two therapeutic methods on the efficacy [overall response rate (ORR)], 1‑year overall survival rate (OSR), safety, negative emotions, nutritional indices, QOL, and immune function indices of patients were analyzed. After treatment, ORR, OSR, levels of nutritional indices [albumin (ALB), prealbumin (PA), and transferrin (TF)], and QOL improvement rate in the CDG were significantly higher than those in the SDG (P<0.05). After treatment, compared with those in the SDG, patients in the CDG had a lower Self‑Rating Anxiety Scale (SAS) score, Self‑Rating Depression Scale (SDS) score, and number of adverse reactions (P<0.05), and significantly improved immune function indices (CD4+, CD8+, and CD4+/CD8+) (P<0.05). S‑1 combined with PC treatment was superior to S‑1 treatment alone in patients with ASC. The patients treated with the combination exhibited improved efficacy (a higher ORR), higher QOL, and improved immune function, and thus this treatment can be clinically popularized.

Related Articles

Journal Cover

August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Wang, Y., & Wang, Y. (2020). Effects of S‑1 combined with palliative care on immune function and quality of life of patients with advanced stomach cancer. Oncology Letters, 20, 2021-2027. https://doi.org/10.3892/ol.2020.11720
MLA
Wang, Y., Li, G."Effects of S‑1 combined with palliative care on immune function and quality of life of patients with advanced stomach cancer". Oncology Letters 20.2 (2020): 2021-2027.
Chicago
Wang, Y., Li, G."Effects of S‑1 combined with palliative care on immune function and quality of life of patients with advanced stomach cancer". Oncology Letters 20, no. 2 (2020): 2021-2027. https://doi.org/10.3892/ol.2020.11720