Open Access

Extravasated platelet aggregation contributes to tumor progression via the accumulation of myeloid‑derived suppressor cells in gastric cancer with peritoneal metastasis

  • Authors:
    • Takahisa Yamaguchi
    • Sachio Fushida
    • Jun Kinoshita
    • Mitsuyoshi Okazaki
    • Satoko Ishikawa
    • Yoshinao Ohbatake
    • Shiro Terai
    • Koichi Okamoto
    • Shinichi Nakanuma
    • Isamu Makino
    • Keishi Nakamura
    • Tomoharu Miyashita
    • Hidehiro Tajima
    • Hiroyuki Takamura
    • Itasu Ninomiya
    • Tetsuo Ohta
  • View Affiliations

  • Published online on: June 10, 2020     https://doi.org/10.3892/ol.2020.11722
  • Pages: 1879-1887
  • Copyright: © Yamaguchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Extravasated platelet aggregation (EPA) serves an important role in the cancer microenvironment during cancer progression, and has been demonstrated to interact with tumor cells in several types of cancer. EPA induces epithelial‑mesenchymal transition (EMT) via transforming growth factor‑β, and also recruits immunosuppressive cells, including regulatory T (Treg) cells and myeloid‑derived suppressor cells (MDSCs). However, the role of EPA in gastric cancer with peritoneal metastasis remains unknown. The present study analyzed the association between EPA and prognosis in patients with gastric cancer with peritoneal metastasis. The present study evaluated 62 patients diagnosed with advanced gastric cancer with peritoneal metastasis between 2001 and 2016. EPA, EMT, Treg cells and MDSCs in peritoneal metastatic lesions were detected by immunohistochemical evaluation of CD42b, SNAIL, FOXP3 and CD33, respectively. CD42b expression was observed in 56.5% (35/62) of peritoneal metastatic lesions. CD42b expression in peritoneal metastatic lesions was associated with poor overall survival compared with lower frequencies (hazard ratio, 2.03; 95% confidence interval, 1.12‑3.69; P=0.018). SNAIL, FOXP3 and CD33 expression were not associated with overall survival, but CD33 expression was markedly higher in CD42b‑positive patients (P=0.022). These results indicated that EPA affects immunosuppression by recruiting MDSCs in the tumor microenvironment via the secretion of soluble factors, resulting in tumor progression. EPA may be a novel therapeutic target for gastric cancer with peritoneal metastasis.

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August-2020
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Spandidos Publications style
Yamaguchi T, Fushida S, Kinoshita J, Okazaki M, Ishikawa S, Ohbatake Y, Terai S, Okamoto K, Nakanuma S, Makino I, Makino I, et al: Extravasated platelet aggregation contributes to tumor progression via the accumulation of myeloid‑derived suppressor cells in gastric cancer with peritoneal metastasis. Oncol Lett 20: 1879-1887, 2020
APA
Yamaguchi, T., Fushida, S., Kinoshita, J., Okazaki, M., Ishikawa, S., Ohbatake, Y. ... Ohta, T. (2020). Extravasated platelet aggregation contributes to tumor progression via the accumulation of myeloid‑derived suppressor cells in gastric cancer with peritoneal metastasis. Oncology Letters, 20, 1879-1887. https://doi.org/10.3892/ol.2020.11722
MLA
Yamaguchi, T., Fushida, S., Kinoshita, J., Okazaki, M., Ishikawa, S., Ohbatake, Y., Terai, S., Okamoto, K., Nakanuma, S., Makino, I., Nakamura, K., Miyashita, T., Tajima, H., Takamura, H., Ninomiya, I., Ohta, T."Extravasated platelet aggregation contributes to tumor progression via the accumulation of myeloid‑derived suppressor cells in gastric cancer with peritoneal metastasis". Oncology Letters 20.2 (2020): 1879-1887.
Chicago
Yamaguchi, T., Fushida, S., Kinoshita, J., Okazaki, M., Ishikawa, S., Ohbatake, Y., Terai, S., Okamoto, K., Nakanuma, S., Makino, I., Nakamura, K., Miyashita, T., Tajima, H., Takamura, H., Ninomiya, I., Ohta, T."Extravasated platelet aggregation contributes to tumor progression via the accumulation of myeloid‑derived suppressor cells in gastric cancer with peritoneal metastasis". Oncology Letters 20, no. 2 (2020): 1879-1887. https://doi.org/10.3892/ol.2020.11722