Open Access

Tumor with slow‑developing and recurring lumps of the external ear with skull base and lung metastasis: A case report

  • Authors:
    • Zhifang Zhai
    • Jie Hu
    • Yi You
    • Xichuan Yang
    • Zhiqiang Song
  • View Affiliations

  • Published online on: June 11, 2020     https://doi.org/10.3892/ol.2020.11724
  • Pages: 1567-1572
  • Copyright: © Zhai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present case report describes a rare case of recurring lumps on the external ear in a 46‑year‑old Chinese male with a history of >10 years, who presented with large irregular red lumps on the right temple and with lung and skull base metastasis. The patient had a lesion in the right auricle and experienced recurrence following surgical resection. A thorough systemic evaluation revealed no other obvious abnormalities. The patient was diagnosed with adenoid cystic carcinoma (ACC), a slow‑growing form of high‑grade adenocarcinoma, and refused any further treatment at the present hospital (The First Affiliated Hospital of Army Medical University). At 2 years post‑follow‑up, the patient had become more frail but was in good spirits. The present study indicated that ACC is a low‑grade and commonly slow‑developing malignancy that primarily arises from a salivary gland, with recurring and metastatic characteristics.

Introduction

Adenoid cystic carcinoma (ACC) is a rare type of cancer that occurs primarily in the major and minor salivary glands (up to 50 and 35%, respectively), but it may also be located at other sites, including the oropharyngeal and nasopharyngeal spaces, external ear, trachea, breast, lacrimal gland, skin and lower female genital tract (1). ACC is most frequently detected in younger- and middle-aged adults, but individuals of any age may be affected, including children. Certain studies have determined a median age of ~60 years and a greater prevalence in female patients (up to 60% of cases) (1,2). ACC usually presents in a localized manner and is limited to the primary sites, but a small proportion of patients exhibit regional lymph node involvement and distant organ metastasis at diagnosis, particularly in the lungs. To date, the biological behavior of ACC has remained poorly understood, and clinically, it is primarily treated by surgery, with or without adjuvant radiation therapy.

Case report

A 46-year-old male patient visited the First Affiliated Hospital of Army Medical University (Chongqing, China) in May 2016 with recurring asymptomatic large irregular red lumps on the right temple for ~6 years. The patient also complained of slight breathlessness on exertion for half a year. The patient's medical history was provided by the patient and the patient's daughter. In early 2006, a slow-growing red nodule arose on the right auricle. It was gradually enlarged to the size of a pigeon egg and was surgically excised at a separate hospital (The First Affiliated Hospital of Chongqing Medical University; Chongqing, China) in January 2010. The histopathological diagnosis was ACC and there was no obvious evidence of spread elsewhere during the general physical examination. After a few months, indurated plaques appeared on the right temple and gradually enlarged over time. For economic reasons, the patient did not seek any medical help until April 2016. The patient refused operative treatment once again. In the recent half year, the tumors on the right temple increased markedly and the patient experienced slight breathlessness after activity and he then visited a hospital.

The patient was underweight (Body Mass Index, 16.7), but appeared reasonably energetic. Physical examination indicated no obvious abnormality besides the skin lesions. There was no associated cervical lymphadenopathy. On local examination, a solitary non-tender proliferative growth, measuring ~5×4 cm with an uneven surface and irregular margins, was arising on the right temple without erosion or bleeding. There were obviously dilated capillaries on the surface. The upper part of the right auricle was absent due to the previous surgery (Fig. 1).

An excision biopsy from the center of tumors on the right temple was performed. Histopathological examination revealed a neoplasm that was sharply demarcated from surrounding the normal parenchyma by reactive gliosis (Fig. 2A). The epithelial tumor cells proliferated with a tubular and cribriform pattern, in certain places forming ductular structures lined by stratified cuboidal cells (Fig. 2B-D). There was a certain amount of hyaline or mucinous material within the tubules and acini or around them. Tubules and acini were highlighted by periodic acid-Schiff stain (Fig. 2E). Immunohistochemistry for cytokeratin (CK)20, carcinoembryonic antigen, S100, thyroid transcription factor 1 and CDX-2 was negative, and thus, neuroendocrine and visceral metastatic adenocarcinoma was excluded. The tumor cells tested positive for CK7, CAM5.2, epithelial membrane antigen and CD117, and the tumor cells in the medial margin of the glandular cavity were positive for P63 (Fig. 3).

A detailed evaluation of the patient was performed. Hematological and biochemical parameters were within normal limits. Cranial MRI revealed multiple mass lesions in the right pharynx, inferior temporal fossa, middle cranial fossa and right frontotemporal subcutaneous, which was hyper-intense on T1-weighted or T2-weighted MRI. The lesion was again enhanced heterogeneously on contrast and the largest mass measured 4.0×3.0×3.5 cm. In the right mastoid process, an enhanced T2 signal indicated the presence of right mastoid process inflammation (Fig. 4A-D). Chest CT (plain and contrast) revealed multiple metastases in both sides of the lungs (Fig. 4E) and it was hyper-densely situated in the mediastinum, suggesting calcification. Ultrasonography of the abdomen indicated no obvious abnormalities. After receiving radiotherapy one time at a local hospital, the patient exhibited no significant clinical improvement and refused further treatment. At a follow-up time of ~2 years, the patient appeared in good spirits, but refused further medical examination and treatment, and had become more frail. The patient was then lost to follow-up.

Discussion

ACC is a rare, slow-growing form of high-grade adenocarcinoma that begins in glandular tissues. ACC occurs primarily in the head and neck, most commonly in the salivary glands, and accounts for 1–2% of all cases of head and neck cancer, ~10% of all salivary neoplasms and ~22% of all salivary gland malignancies (35). ACC may also occur in other locations in the body, including the tracheobronchial tree, breast, foot and cervix (610). ACC of the external ear is rare, and to the best of our knowledge, only a few cases have been reported in the literature in the English language. The incidence rate ranges from 5 to 10% in the external auditory canal (11,12). To date, the incidence rate of ACC of the external ear has not been reported in China. According to previous studies, ACC of the external auditory canal was most commonly diagnosed in the fifth decade of life and was more common in females (11,13).

The clinical symptoms of ACC depend on the location of the tumor. As the tumor growth of ACC is frequently slow, numerous patients may live asymptomatically for a long time, even with metastatic lesions. ACC is rarely associated with regional lymph node involvement and there is only a 13% rate of nodal metastasis in patients with ACC of the external ear (13), which is similar to the 5–10% rate reported for ACC in other head and neck subsites (14). According to the literature, delayed hematogenous metastases occur in 25–50% of patients with ACC and the most common locations of metastases are the lungs and bones (15). Distant metastasis frequently occurs without local recurrence. The patient described in the present case report was a 46-year-old male. While skull base infiltration and lung metastases have been previously observed, no nodal metastasis was detected in this patient. This may be explained by the fact that ACC tends to spread along nerves, known as a perineural invasion, or through the bloodstream (15). In clinical practice, the majority of ACCs in the skin are therefore primary neoplasms. Cutaneous ACC may also represent a direct extension from an underlying salivary gland primary neoplasm. Metastasis from a more distant site has rarely been observed (10). The lesions of the patient in the present case report appeared on the right external ear at first, and subsequently, skull base and lung metastases were detected. As a consequence, the ACC on the right external ear may arise from the underlying ceruminous gland or adjacent salivary gland. ACC is known for having long periods of no growth, or indolence, followed by growth spurts. However, ACC may present as aggressive forms in certain patients, making the course of the ACC unpredictable (10). The long period of the cancer evolving was reflected in the patient of the present case report.

A biopsy is essential for the diagnosis of ACC. It has a characteristic cribiform or sieve-like pattern, in which bundles of epithelial cells surround ducts or glandular structures (16,17). In cutaneous ACC, the tumor tissue is rarely attached to the epidermis or hair follicles. Mitotic activity is rare and peripheral palisading is uncommon (17). Immunohistochemistry is useful for the diagnosis of ACC (16,18). ACC is characterized by slow progression but has a high propensity to invade and metastasize, particularly via perineural invasion, which occurs in ≤70% of ACC cases (19). ACC involving the skull base (orbital contents/bone, sinonasal cavities, nasopharynx, cavernous sinus, clivus, pterygopalatine fossa and infratemporal fossa) is usually identified via novel imaging techniques (20). Clinically, imaging techniques, primarily MRI or CT scan, are useful in order to determine the size and location of the tumor (9,21), and a positron emission tomography scan may also be used to detect metastatic lesions early (22).

The primary treatment modalities are surgery and radiation therapy. Surgical removal of the tumor is the best treatment for ACC as long as it is performed safely and is likely to have a good outcome. Radiation therapy, as an adjuvant therapy following surgery, is particularly effective for ACC by eliminating microscopic cancer cells. Certain studies have indicated that surgery alone was associated with improved overall survival compared with a combination of surgery and radiotherapy, while radiotherapy alone was associated with comparatively worse overall survival (13). It is uncertain whether chemotherapy alters the natural course of metastatic ACC at any site (23,24). With further study on the pathogenesis of ACC, more and more gene mutations have been detected, including epidermal growth factor receptor (EGFR), ALK receptor tyrosine kinase (25) and notch receptor 1 (NOTCH1) (26). At present, targeted therapies are being developed that may be useful in the treatment of ACC, including ALK-targeted gold nanoparticles and EGFR-tyrosine kinase inhibitor gefitinib (6,7). Previous studies have demonstrated that lung ACC is associated with EGFR mutation and that it exhibited a good response to gefitinib (6,7). Distant metastasis is a poor prognostic factor, but nodal metastasis had no impact on overall survival. Local recurrence is another common poor prognostic factor. Local recurrences are frequent and may present as early as 2 years after initial treatment, or after a number of years from the initial treatment (5). In addition, a solid pattern, higher age, black ethnicity and male sex are also poor prognostic factors (11). The survival rate for people with ACC at 5 years was reported to be 80.4–89.1% (20,27). Local recurrence and distant metastasis result in poor long-term survival, with 80–90% of patients succumbing to the disease within 10–15 years (28). According to the literature, skull base metastasis is a predictor of lower overall survival and higher rate of local recurrence (25). Further molecular-level investigations are required in order to improve the current understanding of the unique recurrence and metastasis in ACC. Recently, B-cell-specific moloney murine leukemia virus insertion region (Bmi)-1 mRNA levels were revealed to be markedly elevated in ACC tissues compared with those in the adjacent non-cancerous salivary gland tissues. Further study suggested that Bmi-1 may have a crucial role in ACC progression through interaction with the epithelial-to-mesenchymal transition-associated markers, and may predict poor survival (29).

In conclusion, ACC is an uncommon disease that primarily arises from a salivary gland low-grade malignancy that presents with unpredictable growth and poorly understood prognostic factors. It is imperative for patients to receive an early diagnosis and surgery to remove the tumor in a timely manner, which may markedly improve the survival of these patients.

Acknowledgements

Not applicable.

Funding

The present study was partly supported by the education training research project of the First Affiliated Hospital of Army Medical University (grant no. SWH2015JY07y to ZZ).

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Authors' contributions

ZZ was responsible for the conception, design, content and writing of the manuscript. JH was responsible for acquisition, analysis and interpretation of the images. YY made substantial contributions to conception, design, drafting and revising the manuscript. XY made substantial contributions to acquisition, analysis and interpretation of data and revising the manuscript critically for important intellectual content. ZS made substantial contributions to conception and design, revising and proofreading the manuscript and gave final approval of the version to be published. All authors have read and approved the final manuscript.

Ethics approval and consent to participate

Ethics approval for the present study was obtained from the Ethics Committee of the Southwest Hospital of Chongqing (The First Affiliated Hospital of Army Medical University; Chongqing, China). Informed consent was obtained from the patient.

Patient consent for publication

The patient provided written informed consent for publication of the present case report.

Competing interests

The authors declare that they have no competing interests.

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Spandidos Publications style
Zhai Z, Hu J, You Y, Yang X and Song Z: Tumor with slow‑developing and recurring lumps of the external ear with skull base and lung metastasis: A case report. Oncol Lett 20: 1567-1572, 2020
APA
Zhai, Z., Hu, J., You, Y., Yang, X., & Song, Z. (2020). Tumor with slow‑developing and recurring lumps of the external ear with skull base and lung metastasis: A case report. Oncology Letters, 20, 1567-1572. https://doi.org/10.3892/ol.2020.11724
MLA
Zhai, Z., Hu, J., You, Y., Yang, X., Song, Z."Tumor with slow‑developing and recurring lumps of the external ear with skull base and lung metastasis: A case report". Oncology Letters 20.2 (2020): 1567-1572.
Chicago
Zhai, Z., Hu, J., You, Y., Yang, X., Song, Z."Tumor with slow‑developing and recurring lumps of the external ear with skull base and lung metastasis: A case report". Oncology Letters 20, no. 2 (2020): 1567-1572. https://doi.org/10.3892/ol.2020.11724