Open Access

Prognostic and predictive value of monocarboxylate transporter 4 in patients with breast cancer

  • Authors:
    • Sheng Xiao
    • Hongjia Zhu
    • Yujun Shi
    • Zhenru Wu
    • Hegang Wu
    • Mingjun Xie
  • View Affiliations

  • Published online on: June 25, 2020     https://doi.org/10.3892/ol.2020.11776
  • Pages: 2143-2152
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The Warburg effect explains the large amount of lactic acid that tumour cells produce to establish and maintain the acidic characteristics of the tumour microenvironment, which contributes to the migration, invasion and angiogenesis of tumour cells. Monocarboxylate transporter 4 (MCT‑4) is a key marker of tumour glycolysis and lactic acid production; however, the role of MCT‑4 in breast cancer remains unclear. In the present study, immunohistochemistry (IHC) was used to detect the expression levels of MCT‑4 in tissue microarrays of 145 patients diagnosed with invasive ductal breast cancer. The IHC score was used to assess the intensity of staining and the proportion of positive cells. Western blotting and reverse transcription‑quantitative PCR were also performed to detect the expression levels of MCT‑4 in 30 pairs of breast cancer tissues and adjacent normal tissues. In vitro experiments (EdU incoporation and Cell Counting Kit‑8) were performed to examine the role of MCT‑4 in the breast cancer MCF‑7 cell line. The results of the present study indicated that high MCT‑4 expression was associated with pT status (P=0.018), oestrogen receptor (ER) status (P=0.001), progesterone receptor (PR) status (P=0.024), Ki67 index (P=0.043) and androgen receptor (AR) status (P=0.033). In addition, an association between MCT‑4 expression and pathological grade was observed (P=0.030). Furthermore, univariate (P=0.027) and multivariate (P=0.001) survival analysis revealed that MCT‑4 expression and lymph node involvement were significant independent predictors of breast cancer prognosis. In addition, silencing MCT‑4 expression attenuated breast cancer cell viability. Therefore, MCT‑4 may be used as a potential predictor of invasive breast cancer.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xiao S, Zhu H, Shi Y, Wu Z, Wu H and Xie M: Prognostic and predictive value of monocarboxylate transporter 4 in patients with breast cancer. Oncol Lett 20: 2143-2152, 2020
APA
Xiao, S., Zhu, H., Shi, Y., Wu, Z., Wu, H., & Xie, M. (2020). Prognostic and predictive value of monocarboxylate transporter 4 in patients with breast cancer. Oncology Letters, 20, 2143-2152. https://doi.org/10.3892/ol.2020.11776
MLA
Xiao, S., Zhu, H., Shi, Y., Wu, Z., Wu, H., Xie, M."Prognostic and predictive value of monocarboxylate transporter 4 in patients with breast cancer". Oncology Letters 20.3 (2020): 2143-2152.
Chicago
Xiao, S., Zhu, H., Shi, Y., Wu, Z., Wu, H., Xie, M."Prognostic and predictive value of monocarboxylate transporter 4 in patients with breast cancer". Oncology Letters 20, no. 3 (2020): 2143-2152. https://doi.org/10.3892/ol.2020.11776